Polymerization Enhancers for Cyanoacrylate Skin Adhesive

Abstract

Cyanoacrylate glues are a renowned synthetic tissue sealant that cures rapidly through polymerization at room temperature, felicitating medical glues to treat skin wounds and surgical openings. Despite a wide range of cyanoacrylates available, only 2‐octyl cyanoacrylates (OCA) provides the best biocompatibility. In this study, the polymerization and adhesive properties of 2‐octyl cyanoacrylates (OCA) are explored in the presence of a highly biocompatible and biochemically inert polymer, poly(ethylene glycol) polyhedral oligomeric silsesquioxane (PEG‐POSS). The effect of PEG‐POSS on the polymerization of OCA is examined on a plastic surface and over pig skin. A peel‐test is performed to evaluate the strength of OCA adhesive properties between two pieces of pig skin samples. Additionally, thin films of OCA are prepared using different fillers and evaluated for tear test. The results reveal that when applied on the plastic or pig skin, PEG‐POSS initiated polymerization in OCA yields a high molecular weight OCA polymer with much better adhesive properties compared to commercially available cyanoacrylate adhesives. The relative change in the molecular weights of OCA compared to commercially available cyanoacrylate bioadhesives such as Dermaflex is much higher. The pig skin peeling test shows that OCA needs higher peeling force than Dermaflex.

Fully recyclable multifunctional adhesive with high durability, transparency, flame retardancy, and harsh-environment resistance

“…In particular, because of the stable cross-linked structure and strong interfacial interaction, conventional commercial adhesives, such as epoxy and polyurethane resins ( 7 , 8 ), are difficult to remove from the surface of the bonded substrate after the end of their service life. Consequently, the disposal of massive waste adhesives and their binding substances will be a headache for the future ( 9 ). There is an urgent need to develop sustainable adhesives that can be recycled without complex handling.…”

Bio-macromolecular design roadmap towards tough bioadhesives

“…However, the heat generated during polymerization and the resulting toxic degradation byproducts have limited their use for internal tissues. 159 Moreover, complications associated with exothermic reaction-induced tissue damage, granulomatous keratitis, glaucoma, and cataract formation have further caused concerns for the application of such biomaterials in clinical settings. 160 These complications have motivated researchers to design biosafe alternatives with similar adhesive strengths.…”

Facilely Prepared Thirsty Granules Arouse Tough Wet Adhesion on Overmoist Wounds for Hemostasis and Tissue Repair

“…For example, cyanoacrylate-based tissue adhesives are broadly used. 15 However, their degradation products could induce severe adverse effects. 16 Likewise, Tissue Glu, a synthetic polyurethane tissue adhesive, was efficacious in reducing fluid accumulation.…”

“…In addition, the synthesis of most existing bioadhesives involves the use of nonbiosafe synthetic materials or harmful solvents. For example, cyanoacrylate-based tissue adhesives are broadly used . However, their degradation products could induce severe adverse effects .…”