PEG-based hydrogel membrane coatings

Sagle, Alyson C.; Ju, Hao; Freeman, Benny D.; Sharma, Mukul M.

doi:10.1016/j.polymer.2008.12.019

Cited by 117 publications

(132 citation statements)

References 34 publications

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“…Subsequently, no melting transition was observed, suggesting a lack of crystalline phases thus preventing the xerogel from melting. This phenomenon has previously been observed for other photopolymerised acrylate xerogels [35,40,41]. When incorporating PPG into the hydrogel, the T g value decreased as shown in Fig.…”

Section: Differential Scanning Calorimetrysupporting

confidence: 83%

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Modulating the mechanical properties of photopolymerised polyethylene glycol–polypropylene glycol hydrogels for bone regeneration

et al. 2012

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Hydrogels formulated from single polymers are often insufficient in terms of their mechanical properties for use as bone substitute materials. Hence, hydrogels synthesised from combinations of polymers have been investigated to optimise the performance of such materials. In the current study, polypropylene glycol dimethacrylate was added to polyethylene glycol dimethacrylate of a variety of molecular weights and photopolymerised to form a series of hydrogels. Polyethylene glycol and polypropylene glycol have the same chemical structure with the exception of a methyl group on the later. Herein, the influence of the methyl group of polypropylene glycol on the mechanical properties of hydrogels for bone regeneration applications is reported. For both unconfined and cyclic compression testing, results demonstrated that the incorporation of PEGDMA into the precursor improves the compression strength of the hydrogels. For example, in unconfined compression tests the Young's modulus varied between 6.62 ± 0.31 MPa and 8.08 ± 0.81 MPa with the incorporation of PEGDMA 400.

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Section: Differential Scanning Calorimetrysupporting

confidence: 83%

“…ATR-FTIR confirmed that the surface solution was, in fact, low-molecular weight polymer. Previous studies have reported similar behaviour for other acrylates [38][39][40].…”

Section: Gel Fraction Measurementsupporting

confidence: 75%

Modulating the mechanical properties of photopolymerised polyethylene glycol–polypropylene glycol hydrogels for bone regeneration

et al. 2012

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“…The presence of abundant oxethyl groups in the PEG molecule that are capable of forming hydrogen bonds with water makes PEG a highly water-soluble material. PEG is also a nontoxic, nonimmunogenic, and amphipathic polymer, and it possesses a variety of properties pertinent to biomedical and biotechnical applications [18][19][20] . Thus, adding PEG to A. pernyi SF solutions was selected as a method for reducing gelation time in this study.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Gelation Time and Polyalcohol Effect on Hydrogels from Domestic and Wild Silk Fibroins

Zhao

Xiong

et al. 2012

Advances in Materials Science and Engineering

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Silk fibroin (SF) hydrogels were obtained from both domestic (Bombyx mori) and wild (Antheraea pernyi) silkworms from aqueous silk fibroin solutions at room temperature. The gelation time of the Antheraea pernyi (A. pernyi) SF solution was significantly shorter than that of the Bombyx mori (B. mori) SF solution. The secondary structures of the two kinds of hydrogels were also compared. In order to further reduce the gelation time, various amounts of polyethylene glycol (PEG) were blended with the silk fibroins of A. pernyi and B. mori. The gelation time of both A. pernyi SF and B. mori SF decreased with the increased amount of PEG. After freeze-drying, the hydrogels were characterized through X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and Raman spectroscopy. Results showed that the addition of polyalcohol did not change the main secondary structure of the hydrogels. However, the addition of polyalcohol did reduce the gelation time and triggered additional formation of β-sheets.

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“…The IR spectra are normalized to the peak at 1726 cm −1 , corresponding to the acrylic carbonyl group; these carbonyl groups are largely unaffected during curing and their IR intensities should remain fixed. In contrast, the terminal CH=CH 2 bonds on the PEGDA monomers produce a peak at 1410 cm −1 [17][18][19][20]. A decrease in the intensity of the 1410 cm −1 peak when the sample is exposed to UV light indicates curing.…”

Section: Resultsmentioning

confidence: 99%

Spatially Resolved Measurements of Crosslinking in UV-Curable Coatings Using Single-Sided NMR

2018

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Abstract:The UV-driven photocuring of coatings results in a crosslinked polymeric network. The degree of crosslinking in these coatings is typically assessed via optical spectroscopy; unfortunately, optical methods are typically limited in their maximum depth access. Alternatively, single-sided nuclear magnetic resonance (NMR) can be used to probe the crosslinking of UV-curable coatings in a spatially sensitive manner. Relaxation measurements, which correlate with crosslinking, can be done with a spatial resolution on the order of microns throughout the depth dimension of the coating, regardless of optical transparency of the material. These results can be visualized via a relaxation cross-section that shows the depth at which a particular relaxation value is observed. These measurements are used to probe the effect of a scavenger molecule that is added to the coating mixture, allowing for efficient crosslinking despite the presence of atmospheric oxygen. This method may find purchase in evaluating systems whose crosslinking properties are intentionally varied throughout its thickness; using NMR, these systems, up to approximately one hundred microns thick, can be measured without repositioning or rastering.

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PEG-based hydrogel membrane coatings

Cited by 117 publications

References 34 publications

Modulating the mechanical properties of photopolymerised polyethylene glycol–polypropylene glycol hydrogels for bone regeneration

Modulating the mechanical properties of photopolymerised polyethylene glycol–polypropylene glycol hydrogels for bone regeneration

Comparison of Gelation Time and Polyalcohol Effect on Hydrogels from Domestic and Wild Silk Fibroins

Spatially Resolved Measurements of Crosslinking in UV-Curable Coatings Using Single-Sided NMR

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