Peel of araticum fruit (Annona crassiflora Mart.) as a source of antioxidant compounds with α-amylase, α-glucosidase and glycation inhibitory activities

Justino, Allisson Benatti; Pereira, Mariana Nunes; Vilela, Danielle Diniz; Peixoto, Leonardo Gomes; Martins, Mário Machado; Teixeira, Renata Roland; Miranda, Natália Carnevalli; Silva, Neide M. da; Sousa, Raquel; Oliveira, Alberto de; Espíndola, Foued Salmen

doi:10.1016/j.bioorg.2016.11.001

Cited by 50 publications

(54 citation statements)

References 48 publications

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“…Our antiglycative results are in agreement with the ones previously reported in the literature for berry extracts rich in polyphenols and especially in anthocyanins, which exhibited a strong AGEs inhibitory activity [48]. Moreover, several works also suggested that food byproducts rich in polyphenols are positively correlated with hypoglycemic [51] and antiglycative activities [10,51,52].…”

Section: Evaluation Of Antiglycative Effect Using In Vitro Bovine Sersupporting

confidence: 92%

A New Italian Purple Corn Variety (Moradyn) Byproduct Extract: Antiglycative and Hypoglycemic In Vitro Activities and Preliminary Bioaccessibility Studies

et al. 2020

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The reuse of byproducts from agricultural and food industries represents the key factor in a circular economy, whose interest has grown in the last two decades. Thus, the extraction of bioactives from agro-industrial byproducts is a potential source of valuable molecules. The aim of this work was to investigate the in vitro capacity of byproducts from a new Italian corn variety, named Moradyn, to inhibit the accumulation of advanced glycation end products (AGEs) involved in several chronic age-related disorders. In addition, the hypoglycemic effect of Moradyn was tested by in vitro enzymatic systems. A Moradyn phytocomplex and its purified anthocyanin fraction were able to inhibit fructosamine formation and exhibited antiglycative properties when tested using BSA-sugars and BSA-methylglyoxal assays. These properties could be attributed to the polyphenols, mainly anthocyanins and flavonols, detected by RP-HPLC-DAD-ESI-MS n . Finally, a Moradyn phytocomplex was submitted to a simulated in vitro digestion process to study its bioaccessibility. Moradyn could be considered as a promising food ingredient in the context of typical type 2 diabetes risk factors and the study will continue in the optimization of the ideal formulation to preserve its bioactivities from digestion. Molecules 2020, 25, 1958 2 of 21 pelargonidin-3,5-di-O-glucoside [3]; cyanidin-, peonidin-, and perlargonidin-3-O-di-malonylglucoside [9], cyanidin-3-O-succinylglucoside, cyanidin-3-O-malonylglucoside-5-O-glucoside [5], and cyanidin-3,5di-O-glucoside, this one identified for the first time in purple corn by Žilić et al. [10]. Moreover, several authors have detected ethyl-malonylated anthocyanins that probably originate during the extraction process, and which are known to stabilize pigments, thus prolonging shelf life [5,8].Husk and cob extracts are richer in anthocyanins than kernel extracts, ranging from 0.49% to 4.6% (dry weight) for cobs [1,5]; moreover, husks and cobs differ from kernels for the presence of perlagonidin in their phytocomplex [3].Nowadays, several food byproducts such as olive leaves and oil mill wastewater, grape skin, fruit and vegetable seeds, and artichoke bracts and stems have been deeply investigated for their important role in the inhibition of advanced glycation end products (AGEs) formation [11][12][13][14][15]. AGEs are typical adducts derived from Maillard reaction or non-enzymatic glycation process. These compounds are involved in many chronic diseases, such as cardiovascular pathologies, type 2 diabetes, and neurodegenerative disorders, and their formation increases in association with hyperglycemia and metabolic dysfunctions [16][17][18][19]. Thanks to their high polyphenol content, purple corn byproducts have been associated with several health properties such as antioxidant, anti-inflammatory, and antiglycative activity [2,10,[20][21][22][23]. Moreover, in vitro and in vivo studies demonstrate their capacity in the prevention of cardiovascular and type 2 diabetes risk factors by exerting a strong anti-hypertensi...

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Section: Evaluation Of Antiglycative Effect Using In Vitro Bovine Sersupporting

confidence: 92%

A New Italian Purple Corn Variety (Moradyn) Byproduct Extract: Antiglycative and Hypoglycemic In Vitro Activities and Preliminary Bioaccessibility Studies

et al. 2020

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“…Annona crassiflora Mart., a species from Annonaceae found in Brazilian savannah, is used in traditional medicine for the treatment of wounds [11]. Previous studies have demonstrated various biological activities of extracts from different parts of A. crassiflora, such as antioxidant and antiglycation properties [12,13], nematicidal, antibacterial, and larvicidal activities [14,15], and antimutagenic and antitumoral potential [11]. The fruit peel of A. crassiflora has been recently shown by our group as an exceptional source of polyphenols and alkaloids [13,16].…”

Section: Pro-fibrogenic and Anti-inflammatory Potential Of A Polyphenmentioning

confidence: 99%

“…Previous studies have demonstrated various biological activities of extracts from different parts of A. crassiflora, such as antioxidant and antiglycation properties [12,13], nematicidal, antibacterial, and larvicidal activities [14,15], and antimutagenic and antitumoral potential [11]. The fruit peel of A. crassiflora has been recently shown by our group as an exceptional source of polyphenols and alkaloids [13,16]. Based on a liquid-liquid partitioning of its ethanol extract and HPLC-ESI-MS/MS analysis, most of the polyphenols such as chlorogenic acid, epi-catechin, procyanidins B2 and C1, quercetin-glucosides, caffeoyl-hexosides, feruloyl-hexosides, and kaempferol-hexosides were concentrated and identified in the ethyl acetate and n-butanol fractions (▶ Fig.…”

Section: Pro-fibrogenic and Anti-inflammatory Potential Of A Polyphenmentioning

confidence: 99%

Pro-Fibrogenic and Anti-Inflammatory Potential of a Polyphenol-Enriched Fraction from Annona crassiflora in Skin Repair

et al. 2018

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A polyphenol-enriched fraction from Annona crassiflora fruit peel (PEF-Ac) containing chlorogenic acid, epi-catechin, procyanidins B2 and C1, quercetin-glucoside, kaempferol, and caffeoyl-glucoside was investigated for its anti-inflammatory, pro-angiogenic, and profibrogenic potential in the healing of cutaneous wounds. Four wounds were performed on the back of C57 mice and the lesions were treated with the vehicle (Vaseline and lanolin) and PEF-Ac at concentrations of 2%, 4%, and 6% for 4 and 7 d. Neutrophils and macrophages activities were evaluated indirectly by the activity of myeloperoxidase and N-acetyl-β-D-glycosaminidase, angiogenesis was evaluated by hemoglobin dosing and vessel count in histological sections, and collagen deposition was assessed from histological sections stained with picrosirius red. PEF-Ac demonstrated anti-inflammatory activity, with reduced activities of neutrophil and macrophage in the cutaneous wounds. In addition, there was an increase in the synthesis of types I and III collagen, as well as in the percentage of wound closure, mainly after 4 d of treatment. On the other hand, PEF-Ac did not present an effective pro-angiogenic activity. A. crassiflora fruit peel showed anti-inflammatory and profibrogenic properties, indicating a promising natural source of bioactive molecules for treatment of cutaneous wounds.

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“…The reading of absorbance was performed on a microplate spectrophotometer at 594 nm, and used to calculate cell viability on the basis of the growth control. Further, the CC 50 (concentrations at wich 50% of the cells are viable) values were calculated …”

Section: Methodsmentioning

confidence: 98%

“…Further, the CC 50 (concentrations at wich 50% of the cells are viable) values were calculated. [24,25] The assay was performed twice, containing three replicates, independently. Data are expressed as mean AE standard deviation of experiments.…”

Section: Bioguided Fractionation Of the Etoh Extract Of Leavesmentioning

confidence: 99%

Antifungal and cytotoxicity activities of Banisteriopsis argyrophylla leaves

Oliveira

Silva

Martins

et al. 2018

Journal of Pharmacy and Pharmacology

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Objectives This work aimed to evaluate the antifungal and cytotoxic activity of the EtOH extract and fractions of Banisteriopsis argyrophylla leaves, and to perform the identification of these bioactive metabolites. Methods The EtOAc fraction (EAF) obtained from the ethanolic extract of B. argyrophylla leaves showed better antifungal potential against Candida spp. In this fraction, ten flavonoids have been identified by UHPLC‐ESI‐MSn. Then, EAF was submitted to column chromatography to give four new fractions (A1–A4). The cytotoxicity was determined against Vero cells. Key findings The EAF showed better antifungal potential against Candida spp. with minimum inhibitory concentrations (MICs) between 31.25 and 93.75 μg/ml. The (–)‐catechin (fraction A1) showed a MIC of 2.83 μg/ml against Candida glabrata. Fractions A2, A3 and A4 were rich in quercetins and kaempferols and showed good inhibitory concentrations (5.86–46.87 μg/ml) against C. albicans, C. glabrata and C. tropicalis. Conclusions The EtOH extract, fractions and the isolated (–)‐catechin showed lower toxicity to Vero cells than cisplatin, used as a positive control. Thus, the leaves of B. argyrophylla are a promising source of antifungal agents.

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Peel of araticum fruit (Annona crassiflora Mart.) as a source of antioxidant compounds with α-amylase, α-glucosidase and glycation inhibitory activities

Cited by 50 publications

References 48 publications

A New Italian Purple Corn Variety (Moradyn) Byproduct Extract: Antiglycative and Hypoglycemic In Vitro Activities and Preliminary Bioaccessibility Studies

A New Italian Purple Corn Variety (Moradyn) Byproduct Extract: Antiglycative and Hypoglycemic In Vitro Activities and Preliminary Bioaccessibility Studies

Pro-Fibrogenic and Anti-Inflammatory Potential of a Polyphenol-Enriched Fraction from Annona crassiflora in Skin Repair

Antifungal and cytotoxicity activities of Banisteriopsis argyrophylla leaves

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