Pedunculated solitary fibrous tumours arising from the pleura

Poyraz, A.S.; Kılıç, Dalokay; Hatipoğlu, Ahmet; Bakırcı, Tülay; Bilezikçi, Banu

doi:10.4081/monaldi.2006.563

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…However, subsequent studies using immunohistochemical techniques and electron microscopy have shown that SFT originates from dendritic mesenchymal cells that are CD34-positive and capable of differentiating into fibroblasts, myofibroblasts, and vascular epithelial cells. [5][6][7] Although SFT can occur in various locations in the body, primary bladder SFT is rare, and patients may present with urinary symptoms and pelvic compression or be asymptomatic. In this case, the diagnosis was incidental during the evaluation of other diseases, and the patient did not have significant urinary symptoms.…”

Section: Discussionmentioning

confidence: 99%

A case report and literature review on primary solitary fibrous tumor of the bladder

Zhang

2023

Medicine

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Rationale: Solitary fibrous tumors (SFT) is a rare mesenchymal tumor originating from a CD34-positive dendritic mesenchymal cell, most of which is benign, the most common sites is pleura and mediastinum, and rarely in the bladder. The clinical manifestations are mainly related to the tumor volume. When the tumor volume is large, it will compress the surrounding tissues or organs and cause corresponding symptoms. Laparoscopic Incision biopsy is effective means for diagnosing SFT. Patient concerns: A 70-year-old female patient was admitted to the hospital with a bladder neoplasm detected by computed tomography scan after experiencing intestinal obstruction 3 days following esophageal cancer surgery. She denied any history of tumor disease. Diagnoses: No abnormality was found in the physical examination and laboratory testing after admission. Ultrasound imaging showed a large solid mass with low echogenicity in the bladder. Urological computed tomography with 3D reconstruction revealed a large cystic-solid mass located on the right wall of the bladder, measuring approximately 6.8 cm × 7.1 cm × 6.5 cm, with uneven density and mild inhomogeneous enhancement after contrast administration. Cystoscopy revealed a large mucosal bulge on the right wall of the bladder and laparoscopic exploration revealed a smooth-surfaced round mass, approximately 7 cm in size. Interventions: Incision biopsy was performed to make a clear diagnosis, and appropriate tissue specimens were obtained for pathological testing. Outcomes: The patient was diagnosed as SFT according to pathology. The patient was followed up for 6 months after surgery, and no recurrence was observed. Lessons: SFT occurring in the bladder are extremely rare, and the site is scarcely reported in the relevant literature; thus, it is easy to misdiagnose and laparoscopic incision biopsy may be a good choice.

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Section: Discussionmentioning

confidence: 99%

A case report and literature review on primary solitary fibrous tumor of the bladder

Zhang

2023

Medicine

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“…CT 呈现肋骨压迹的胸膜孤立性纤维性肿瘤 1 例分析王继芳，姚以刚，石振东，何永满沈阳医学院附属铁法煤业集团总医院，辽宁铁岭，中国通讯作者：石振东，Email：szd666888@163.com 【摘要】目的探讨胸膜孤立性纤维性肿瘤(SFTP)的临床、影像学特征及诊治方法。方法回顾性分析 1 例 CT 呈现肋骨压迹的胸膜 SFT 的诊断过程，并复习有关文献。结果该患者无明显临床症状；胸部 CT 示右侧后上胸壁胸膜外见一个约 3.4cm ×2.4cm 大小的类圆形软组织密度影，边界与胸膜分界不清，临近肋骨有压迹形成，增强扫描病灶强化稍不均匀，灶内可见小斑片状低强化影；病理检查示肿瘤组织主要由梭形细胞组成，免疫组织化学示 CD34、CD99、SMA 阳性。结论 SFTP 是一种少见的梭形细胞肿瘤，临床表现及影像学检查无特异性，CT 呈现肋骨压迹并非神经源性肿瘤的专有特征，诊断主要依靠病理及免疫组织化学检查，手术治疗是首选的治疗方法，术后预后较好。【关键词】纤维瘤；胸膜肿瘤；计算机断层扫描；免疫组织化学；鉴别诊断孤立性纤维性肿瘤(solitary fibrous tumor，SFT)是一种少见的间叶源性梭形细胞肿瘤，由 klemperer 和 Rabin 首次描述 [1] ，曾称为"胸膜下纤维瘤"、"间皮下纤维瘤"和"局限性纤维性间皮瘤"等，国外文献报道其发病率仅为 28/10 万，最常见的发病部位是脏层胸膜 [2] 。由于该病发现前常无明显症状，而在体检 [3] ，但曾有家族性发病的报道。最初认为 SFT 起源于间皮细胞，随着组织学、免疫组织化学、电镜、分子生物学技术的发展和应用，目前研究显示 SFT 发生与间皮并无关联，并已证实 SFT 起源于一种 CD34 阳性的树突状间叶细胞，具有向纤维母细胞、肌纤维母细胞、血管外皮细胞及血管内皮细胞分化的特性 [4] 。SFT 多为良性或交界性，恶性者仅占 20% [5] ，常为单发，偶而多发，约 80%见于胸膜，胸膜外其他结缔组织也可发生，以皮下软组织、眼眶、颅内及盆腔多见 [6] 。临床症状依发生部位和肿瘤大小不同而异，多数患者表现为局部缓慢性生长的无痛性肿块，当肿块巨大累及重要脏器时可出现相应症状。发生于中枢神经系统的 SFT，因肿瘤阻碍脑脊液回流，可出现颅高压的表现。少数患者可伴有肺性肥大性骨关节病 [2] 、顽固性低血糖(3%～4%) [7] 、杵状指(趾)及胸腔积液 [8] 。…”

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Ct呈现肋骨压迹的胸膜孤立性纤维性肿瘤1例分析

et al. 2014

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Objective: To explore the clinical and radiographic characteristics, methods of diagnosis and treatment of solitary fibrous tumor of the pleura (SFTP). Methods: To retrospectively analyze the diagnostic process of 1 case of SFT patients with computed tomography (CT) presenting rib impression, and to have literature review. Results: The patients had obvious clinical symptoms. His chest CT showed a 3.4cm×2.4cm size round soft tissue density in the right upper chest wall outside pleura, the boundary between pleura and the image is not clear, adjacent rib showed traces of impression formation, enhanced scanning lesions was slightly uneven, range small patchy low enhancement. His pathological examination showed that the tumor tissue is mainly composed of spindle cells, and immunohistochemistry showed CD34, CD99, SMA positive. Conclusions: SFTP is a rare spindle cell tumor, clinical manifestation and imaging are not specific. The pressure trace CT presented is not proprietary features of neurogenic tumors in the ribs. The diagnosis of SFTP mainly depends on the pathological and immunohistochemistry examination. Operation is the first choice of the treatment, and prognosis is good after the operation.

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Solitary fibrous tumour of the pleura masquerading as catecholamine-secreting paraganglioma

et al. 2013

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SUMMARYA 33-year-old African-American woman presented with left-sided chest pain for 2 months before admission. Physical examination revealed no breath sound in the left chest and CT scan of the chest showed total obliteration of the left pleural cavity. The patient also had hypertension and elevated urinary metanephrines, leading to a tentative diagnosis of a catecholaminesecreting paraganglioma. MRI revealed a large, heterogeneous soft tissue mass that occupied the entire left chest cavity, causing displacement of the heart and mediastinal structures to the right. Through a left thoracotomy incision, a tumour weighing 2790 g was removed along with a small portion of adherent lung. The tumour was positive for CD34 but negative for S-100, keratin, desmin and progesterone-receptor, which is consistent with pathological diagnosis of a solitary fibrous tumour of the pleura. The patient remains symptom free 4 years after the operation. BACKGROUND

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Pedunculated solitary fibrous tumours arising from the pleura

Cited by 5 publications

References 10 publications

A case report and literature review on primary solitary fibrous tumor of the bladder

A case report and literature review on primary solitary fibrous tumor of the bladder

Ct呈现肋骨压迹的胸膜孤立性纤维性肿瘤1例分析

Solitary fibrous tumour of the pleura masquerading as catecholamine-secreting paraganglioma

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