Pediococcus acidilactici intake decreases the clinical severity of atopic dermatitis along with increasing mucin production and improving the gut microbiome in Nc/Nga mice

Jeong, Do-Youn; Ryu, Myeong-Seon; Yang, Hee-Jong; Jeong, Seong-Yeop; Zhang, Ting; Yang, Hye Jeong; Kim, Min Jung; Park, Sunmin

doi:10.1016/j.biopha.2020.110488

Cited by 18 publications

(13 citation statements)

References 41 publications

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“…Tralokinumab, a monoclonal antibody to neutralize IL-13, had been reported to improve the clinical in adults with AD in randomized, double-blind, multicenter, and placebocontrolled phase III trials (118). Pediococcus acidilactici intake reduced the mRNA expression of IL-4, TNF-a, and IL-13 in dorsal skin and improved the clinical severity of AD (119). Levels of TSLP are high in the lesions of AD patients and TSLP is a key protein in the development of AD (120).…”

Section: Regulation Of Probiotics On Immune Responses In Admentioning

confidence: 99%

Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review

Fang

Zhang

et al. 2021

Front. Immunol.

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Atopic dermatitis (AD) is a public health concern and is increasing in prevalence in urban areas. Recent advances in sequencing technology have demonstrated that the development of AD not only associate with the skin microbiome but gut microbiota. Gut microbiota plays an important role in allergic diseases including AD. The hypothesis of the “gut-skin” axis has been proposed and the cross-talk mechanism between them has been gradually demonstrated in the research. Probiotics contribute to the improvement of the intestinal environment, the balance of immune responses, regulation of metabolic activity. Most studies suggest that probiotic supplements may be an alternative for the prevention and treatment of AD. This study aimed to discuss the effects of probiotics on the clinical manifestation of AD based on gut microbial alterations. Here we reviewed the gut microbial alteration in patients with AD, the association between gut microbiota, epidermal barrier, and toll-like receptors, and the interaction of probiotics and gut microbiota. The potential mechanisms of probiotics on alleviating AD via upregulation of epidermal barrier and regulation of immune signaling had been discussed, and their possible effective substances on AD had been explored. This provides the supports for targeting gut microbiota to attenuate AD.

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Section: Regulation Of Probiotics On Immune Responses In Admentioning

confidence: 99%

Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review

Fang

Zhang

et al. 2021

Front. Immunol.

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“…Taking into account that some studies have reported the ability of probiotic microorganisms administered orally to exert beneficial effects on the skin [ 40 , 41 , 42 ], we decided to study the ability of W. viridescens UCO-SMC3 to resist simulated gastrointestinal conditions in vitro . These studies were carried out in comparison with the probiotic strain L. fermentum UCO-979C [ 43 , 44 ].…”

Section: Resultsmentioning

confidence: 99%

“…Considering that acne lesions may vary in number and extension during the natural course of the disease, various measurements have been developed to assess the clinical severity, with the clinical examination and photographic documentation the most commonly used [ 38 , 39 , 40 ]. For the quantification of the clinical examination, a score was determined considering a grading system to estimate the extent of involvement and lesion counting.…”

Section: Methodsmentioning

confidence: 99%

Characterization of Weissella viridescens UCO-SMC3 as a Potential Probiotic for the Skin: Its Beneficial Role in the Pathogenesis of Acne Vulgaris

et al. 2021

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Previously, we isolated lactic acid bacteria from the slime of the garden snail Helix aspersa Müller and selected Weissella viridescens UCO-SMC3 because of its ability to inhibit in vitro the growth of the skin-associated pathogen Cutibacterium acnes. The present study aimed to characterize the antimicrobial and immunomodulatory properties of W. viridescens UCO-SMC3 and to demonstrate its beneficial effect in the treatment of acne vulgaris. Our in vitro studies showed that the UCO-SMC3 strain resists adverse gastrointestinal conditions, inhibits the growth of clinical isolates of C. acnes, and reduces the adhesion of the pathogen to keratinocytes. Furthermore, in vivo studies in a mice model of C. acnes infection demonstrated that W. viridescens UCO-SMC3 beneficially modulates the immune response against the skin pathogen. Both the oral and topical administration of the UCO-SCM3 strain was capable of reducing the replication of C. acnes in skin lesions and beneficially modulating the inflammatory response. Of note, orally administered W. viridescens UCO-SMC3 induced more remarkable changes in the immune response to C. acnes than the topical treatment. However, the topical administration of W. viridescens UCO-SMC3 was more efficient than the oral treatment to reduce pathogen bacterial loads in the skin, and effects probably related to its ability to inhibit and antagonize the adhesion of C. acnes. Furthermore, a pilot study in acne volunteers demonstrated the capacity of a facial cream containing the UCO-SMC3 strain to reduce acne lesions. The results presented here encourage further mechanistic and clinical investigations to characterize W. viridescens UCO-SMC3 as a probiotic for acne vulgaris treatment.

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“…Some studies indicated that compared with healthy controls, the abundance of Bacilli was increased in encephalitis ( 26 ) and Graves’ disease patients ( 27 ). Increased Lactobacillales abundance was observed in autoimmune liver disease ( 28 ), atopic dermatitis ( 29 ), type 1 diabetes ( 30 ), and Graves’ disease ( 27 ) patients. These studies indicated that the Bacilli and Lactobacillales might have the effects of promoting inflammation.…”

Section: Discussionmentioning

confidence: 99%

Causal Effects of Gut Microbiome on Systemic Lupus Erythematosus: A Two-Sample Mendelian Randomization Study

et al. 2021

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The observational association between gut microbiome and systemic lupus erythematosus (SLE) has been well documented. However, whether the association is causal remains unclear. The present study used publicly available genome-wide association study (GWAS) summary data to perform two-sample Mendelian randomization (MR), aiming to examine the causal links between gut microbiome and SLE. Two sets of MR analyses were conducted. A group of single nucleotide polymorphisms (SNPs) that less than the genome-wide statistical significance threshold (5 × 10-8) served as instrumental variables. To obtain a comprehensive conclusion, the other group where SNPs were smaller than the locus-wide significance level (1 × 10-5) were selected as instrumental variables. Based on the locus-wide significance level, the results indicated that there were causal effects of gut microbiome components on SLE risk. The inverse variance weighted (IVW) method suggested that Bacilli and Lactobacillales were positively correlated with the risk of SLE and Bacillales, Coprobacter and Lachnospira were negatively correlated with SLE risk. The results of weighted median method supported that Bacilli, Lactobacillales, and Eggerthella were risk factors for SLE and Bacillales and Coprobacter served as protective factors for SLE. The estimates of MR Egger suggested that genetically predicted Ruminiclostridium6 was negatively associated with SLE. Based on the genome-wide statistical significance threshold, the results showed that Actinobacteria might reduce the SLE risk. However, Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) detected significant horizontal pleiotropy between the instrumental variables of Ruminiclostridium6 and outcome. This study support that there are beneficial or detrimental causal effects of gut microbiome components on SLE risk.

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Pediococcus acidilactici intake decreases the clinical severity of atopic dermatitis along with increasing mucin production and improving the gut microbiome in Nc/Nga mice

Cited by 18 publications

References 41 publications

Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review

Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review

Characterization of Weissella viridescens UCO-SMC3 as a Potential Probiotic for the Skin: Its Beneficial Role in the Pathogenesis of Acne Vulgaris

Causal Effects of Gut Microbiome on Systemic Lupus Erythematosus: A Two-Sample Mendelian Randomization Study

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