Pediatric Sleep Difficulties after Moderate–Severe Traumatic Brain Injury

Sumpter, Ruth E.; Dorris, Liam; Kelly, Thomas M.; McMillan, T. M.

doi:10.1017/s1355617713000465

Cited by 44 publications

(33 citation statements)

References 25 publications

(46 reference statements)

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“…However, sleep disturbances were common post-injury and included excessive daytime sleepiness, increased sleep latency and circadian rhythm disruption, though the latter was not as common (Gagner et al 2015). One such prospective study of 15 patients demonstrated that sleep onset and maintenance difficulties were significantly increased in the TBI group when compared to their siblings (Sumpter et al 2013). A similar recent prospective study evaluated 100 adolescent patients three to twelve months following TBI for sleep disturbances using questionnaires and actigraphy (Tham et al 2015).…”

Section: Special Considerations In the Pediatric Populationmentioning

confidence: 99%

A review of sleep disturbances following traumatic brain injury

Zuzuárregui

Bickart

Kutscher

2018

Sleep Science Practice

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Background: Sleep disorders are common following traumatic brain injury (TBI). Methods: We review the literature regarding sleep disturbances in the acute and chronic phase following TBI in both the adult and pediatric population. Results: Acute and chronic disruption of sleep commonly follows TBI and contributes to morbidity commonly seen post-injury in both adults and children. This includes the direct effect of TBI leading to sleep disruption, as well as sleep disorders resulting from TBI itself. Pre-TBI neurocognitive testing is important to determine a baseline prior to injury, while disrupted sleep can also prolong recovery after TBI. Early recognition of sleep disturbances post-injury can lead to earlier treatment and limit the sequelae of TBI, as well as assist in recovery. Conclusion: We suggest that evaluation for sleep disturbances following TBI is a critical component of post-TBI assessment and management.

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Section: Special Considerations In the Pediatric Populationmentioning

confidence: 99%

A review of sleep disturbances following traumatic brain injury

Zuzuárregui

Bickart

Kutscher

2018

Sleep Science Practice

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“…Several studies have shown more sleep disturbance in children with TBI than in healthy children or in those with orthopedic injuries (OIs). [6][7][8][9][10] Sleep problems have been demonstrated in children with both mild (mTBI) and more severe TBI (sTBI), persisting up to 3 years postinjury, as measured by self-and parent ratings as well as by objective sleep-monitoring measures (e.g., actigraphy and polysomnography [PSG]). 7,10 However, not all studies have found sleep problems to be associated with TBI or to be related to injury severity.…”

Section: Introductionmentioning

confidence: 99%

Sleep Problems and Their Relationship to Cognitive and Behavioral Outcomes in Young Children with Traumatic Brain Injury

Shay

Yeates

Walz

et al. 2014

Journal of Neurotrauma

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This study examined the effect of traumatic brain injury (TBI) in young children on sleep problems and the relationship of sleep problems to neuropsychological and psychosocial functioning. Participants were drawn from an ongoing longitudinal study of injury in young children recruited from 3 to 6 years of age. They constituted three groups: orthopedic injury (OI; n = 92), complicated mild/moderate TBI (mTBI; n = 55); and severe TBI (sTBI; n = 20). Caregivers completed the Children's Sleep Habits Questionnaire (CSHQ), as well as ratings of behavioral adjustment, adaptive functioning, and everyday executive function at 1, 6, 12, and 18 months postinjury. Retrospective ratings of preinjury sleep and psychosocial functioning were obtained at the initial assessment. Children completed neuropsychological testing at all occasions. Children with complicated mTBI demonstrated more total sleep problems than children with OI at 6 months postinjury, but not at 12 or 18 months. Children with sTBI displayed more bedtime resistance and shorter sleep duration than those with complicated mTBI or OI at several occasions. Across groups, total sleep problems predicted more emotional and behavioral problems and worse everyday executive function as rated by parents across follow-up occasions. In contrast, sleep problems were generally not related to neuropsychological test performance. The results suggest that young children with TBI demonstrate more sleep problems than children with injuries not involving the head. Sleep problems, in turn, significantly increase the risk of poor psychosocial outcomes across time, but are not associated with worse neuropsychological test performance.

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“…The short-term and long-term consequences of brain injury o en include disrup on of the day/night rhythm [255,256]. The expression of Bmal1 and Cry1 is deregulated in mice with trauma c brain injury [257].…”

Section: Genotype-phenotype Correlations For Mutations and Polymorphimentioning

confidence: 99%

DNA damage and the circadian clock

Chakarov¹,

Petkova²,

Russev³

et al. 2014

Biodiscovery

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The role of the circadian clock has already been demonstrated for virtually all physiological processes, but it was only recently shown that cells were more sensi ve to DNA damage at specific mes of the day; that the peak of synthesis of mRNA and proteins of genes coding for products involved directly or indirectly in DNA repair was differen ally med in different ssues; and that the growth of some types of cancer followed a circadian pa ern. The paper reviews the specifici es of the clockwork mechanism in living cells associated with repair of DNA damage with regards to its role in ageing and carcinogenesis. The role of heritable polymorhisms and soma c muta ons in the risk for development of common diseases (cancer, but also other types of diseases and condi ons, such as obesity and metabolic syndrome), their course and the possible outcomes is reviewed in animal models and in man. The circadian oscilla ons in the levels of major proteins of DNA-damage related signalling and DNA repair are discussed in rela on to differen al mechanisms of defence against genotoxic damage. The paper outlines the modern concept of 'chronotherapy' -that is, an cancer therapy administered at specific mes of the day/ night cycle that could be associated with be er outcomes in some pa ents and analyses the individual variance in the tolerability of chronotherapy vs. maximum-dose an cancer therapy.Cita on: Chakarov S, Petkova R, Russev GCh, Zhelev N. DNA damage and the circadian clock.

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Pediatric Sleep Difficulties after Moderate–Severe Traumatic Brain Injury

Cited by 44 publications

References 25 publications

A review of sleep disturbances following traumatic brain injury

A review of sleep disturbances following traumatic brain injury

Sleep Problems and Their Relationship to Cognitive and Behavioral Outcomes in Young Children with Traumatic Brain Injury

DNA damage and the circadian clock

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