Pediatric sleep and epilepsy

Rodríguez, Alejandro W.

doi:10.1007/s11910-007-0052-0

Cited by 16 publications

(15 citation statements)

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“…The results described here further strengthen the connection between aberrant sleep and seizures (Rodriguez, 2007;Kothare & Kaleyias, 2010;Nunes, 2010;van Golde et al, 2011) and confirm an association between pediatric epilepsy severity and degree of sleep disturbance (Wirrell et al, 2005;Batista & Nunes, 2007;Ong et al, 2010). In this study, we found parasomnia and night wakening sleep domains among those most affected by pediatric epilepsy.…”

Section: Discussionsupporting

confidence: 88%

Impact of pediatric epilepsy on sleep patterns and behaviors in children and parents

Larson¹,

Ryther²,

et al. 2012

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SUMMARYPurpose: Disrupted sleep patterns in children with epilepsy and their parents are commonly described clinically. A number of studies have shown increased frequency of sleep disorders among pediatric epilepsy patients; however, few have characterized the association between epilepsy and parental sleep quality and household sleeping arrangements. The purpose of this study was to explore the effect of pediatric epilepsy on child sleep, parental sleep and fatigue, and parent-child sleeping arrangements, including room sharing and cosleeping. Methods: Parents of children 2 to 10 years of age with and without epilepsy completed written questionnaires assessing seizure history, child and parent sleep, and household sleeping arrangements. Children's Sleep Habits Questionnaire (CSHQ) scores were used to evaluate sleep disturbances for the child. The Pittsburgh Sleep Quality Index (PSQI) and the Iowa Fatigue Scale (IFS) were used to evaluate parental sleep and fatigue, respectively. The Early Childhood Epilepsy Severity Scale (E-Chess) was used to assess epilepsy severity. Key Findings: One hundred five households with a child with epilepsy and 79 controls participated in this study. Households with a child with epilepsy reported increased rates of both parent-child room sharing (p < 0.001) and cosleeping (p = 0.005) compared to controls. Children with epilepsy were found to have greater sleep disturbance by total CSHQ score (p < 0.001) and the following subscores: parasomnias (p < 0.001), night wakings (p < 0.001), sleep duration (p < 0.001), daytime sleepiness (<0.001), sleep onset delay (p = 0.009), and bedtime resistance (p = 0.023). Parents of children with epilepsy had increased sleep dysfunction (p = 0.005) and were more fatigued (p < 0.001). Severity of epilepsy correlated positively with degree of child sleep dysfunction (0.192, p = 0.049), parental sleep dysfunction (0.273, p = 0.005), and parental fatigue (0.324, p = 0.001). Antiepileptic drug polytherapy was predictive of greater childhood sleep disturbances. Nocturnal seizures were associated with parental sleep problems, whereas room sharing and cosleeping behavior were associated with child sleep problems. Within the epilepsy cohort, 69% of parents felt concerned about night seizures and 44% reported feeling rested rarely or never. Finally, 62% of parents described decreased sleep quality and/or quantity with cosleeping. Significance: Pediatric epilepsy can significantly affect sleep patterns for both the affected child and his or her parents. Parents frequently room share or cosleep with their child, adaptations which may have detrimental effects for many households. Clinicians must not only be attentive to the sleep issues occurring in pediatric patients with epilepsy, but also for the household as a whole. These data provide evidence of a profound clinical need for improved epilepsy therapeutics and the development of nocturnal seizure monitoring technologies.

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Section: Discussionsupporting

confidence: 88%

Impact of pediatric epilepsy on sleep patterns and behaviors in children and parents

Larson¹,

Ryther²,

et al. 2012

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“…Furthermore, children with more challenging daytime behaviors, such as hyperactivity or environmental hypersensitivities, may have more difficulties settling down to sleep. Co-morbid conditions such as epilepsy and psychiatric disorders, and their pharmacological treatments, may also affect sleep [72, 73]. …”

Section: Sleep Disturbancesmentioning

confidence: 99%

Common neurological co-morbidities in autism spectrum disorders

Maski

Jeste²,

Spence

2011

Current Opinion in Pediatrics

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Purpose of Review Autism Spectrum Disorders (ASD) are heterogeneous neurodevelopmental disorders associated with various co-morbidities. Neurological co-morbidities include motor impairments, epilepsy and sleep dysfunction. These impairments are receiving more attention recently, perhaps because of their significant impact on the behavior and cognitive function of children with ASD. Here, we review the epidemiology, etiology and clinical approach to these neurological co-morbidities and highlight future research directions. Recent Findings Motor impairments include stereotypies, motor delays and deficits, such as dyspraxia, incoordination and gait problems. Sleep dysfunction typically presents as difficulty with sleep onset and prolonged awakenings during the night. Recent data suggest that abnormalities in melatonin may affect sleep and may be a potential treatment target. There is no classic epilepsy syndrome associated with ASD. Intellectual disability, syndromic autism and female gender are specific risk factors. Recent research has focused on identifying the overlapping pathways between these neurological co-morbidities and the core deficits in ASD, which may have direct and powerful implications for treatment and prognosis. Summary Motor impairment, epilepsy and sleep dysfunction are common neurological co-morbidities in ASD. Clinicians should be aware that recognition and treatment of these issues may improve the function and outcome of children with ASD.

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Section: Introductionunclassified

“…Nöbetler nöronların anormal, istemsiz, zaman sınırlı ritmik deşarjlarından kaynaklanan paroksismal semptomlarıdır. Konvülsiyonlar, nöbet esnasında oluşan kas kasılmalarını ifade eder (6,(10)(11)(12)(13)(14)(15)(16)(17).Epilepsili çocukların büyük bir kısmında tek antiepileptik ilaçla, daha az bir kısmında çoklu antiepileptik ilaçla nöbet kontrolü sağlanırken diğerlerinde ise çoklu antiepileptik ilaç kullanılmasına rağmen nöbet kontrolü sağlanamamaktadır. İşte bu çoklu antiepileptiklere rağmen nöbet kontrolü sağlanamayan vakalar dirençli epilepsi grubunu oluşturmaktadır (18)(19)(20).…”

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Evaluating the First Type of Seizure and Variety of Seizures in Resistance Epileptic Patients

Cat¹,

Okan²

2019

JAREM

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ÖZET Amaç: Epilepsili çocukların çoklu antiepileptik ilaç kullanılmasına rağmen nöbet kontrolü sağlanamayan kısmı dirençli epilepsi grubunu oluşturmaktadır. Bu çalışmanın amacı epilepsili hastalarda direnç gelişimi açısından risk faktörü olabileceğini düşündüğümüz ilk nöbet tipi ve nöbetlerin çeşitliliği ile direnç gelişimi arasındaki ilişkiyi değerlendirmektir.Yöntemler: Uludağ Üniversitesi Tıp Fakültesi Polikliniğinde epilepsi tanısı almış, en az iki yıldır izlemde olan 01. 01.2009-31.12.2012 tarihleri arasında takip edilen hastaların dosyaları geriye yönelikincelenerek veriler elde edildi.Bulgular: Vakaların 120'si kız (%49), 125'i erkek (%51) çocuktan oluşmaktaydı. Yaş aralığı 1 ile 18 yaş arasında değişmekte olup median değer 8,3 (1-18) yaş olarak bulundu. Dirençli epilepsi tanı kriterlerine uyan 245 hastadan 120'si iyi kontrollü grup olarak bulundu. Dirençli epilepsili hastalarda ilk nöbet tipi ve nöbetlerin çeşitliliği açısından bu iki grup hastanın bulguları karşılaştırıldı. En fazla görülen nöbet tipi dirençli grupta myoklonik vasıflı nöbet (%25,6) iken, iyi kontrollü grupta fokal başlangıçlı jeneralize nöbet (%34,2) olarak bulundu. Her iki grup arasında nöbet tipi istatiksel olarak anlamlı fark bulundu (p=0,001). Nöbet çeşitliliği açısından bakıldığında üç ve daha fazla çeşitte nöbet geçiren hastaların dirençli grupta daha fazla (%60,7) olduğu görüldü ve gruplar arasında istatistiksel olarak anlamlı fark bulundu (p<0,05).Sonuç: Bu çalışmada ilk nöbet tipi ve nöbet çeşitliliğinin epilepsili hastalarda direnç gelişimi açısından önemli risk faktörleri olduğunu saptadık. ABSTRACTObjective: Despite the fact that epilepsy children who use multiple antiepileptic drugs,part of the epileptic group that does not have seizure control constitutes a resistant epilepsy group.This study evaluates the first type of seizure and the variety of seizures and resistance development that we think might be a risk factor for developmentof resistance in epileptic patients.Methods: Data were obtained retrospectiveliy from patient files of patients diagnosed with epilepsy and monitored for at least two years between 01.Results: 120 were girls (49%) and 125 were male (51%) of the cases. The age range ranged from 1 to 18 years and the median value was 8.3 (1-18) years. 120 of the 245 patients who met the diagnostic criteria for resistant epilepsy were found as well controlled. In patients with resistant epilepsy, the first seizure type and the variety of seizures were compared in these two groups of patients. It was observed that most common type of seizure seen in refractory group was myoclonic seizures (25,6%)whereas most common type of seizure was generalized seizure with focal onset (34,2%) in wellcontrolled group. There was statistically significant difference between groups (p<0,05). In terms of seizure types; it was observed that refractory group included more patients (60,7%) with three or more types of seizure (p<0,05). Conclusion:In this study, we found that the first seizure type and seizure variability were important r...

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Pediatric sleep and epilepsy

Cited by 16 publications

References 42 publications

Impact of pediatric epilepsy on sleep patterns and behaviors in children and parents

Impact of pediatric epilepsy on sleep patterns and behaviors in children and parents

Common neurological co-morbidities in autism spectrum disorders

Evaluating the First Type of Seizure and Variety of Seizures in Resistance Epileptic Patients

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