Pediatric Retinal Detachment in an Asian Population With High Prevalence of Myopia

Tsai, Andrew; Wong, Chee Wai; Lim, Laurence Shen; Yeo, Ian; Wong, Doric; Wong, Edmund; Ang, C. H.; Ong, Sze Guan; Lee, Shu Yen; Tan, Gavin Sw

doi:10.1097/iae.0000000000002238

Cited by 19 publications

(15 citation statements)

References 30 publications

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“…Depending on the location of the detachment, involvement of the macula and other co‐existing morbidities, vision may be affected. Surgical management of retinal detachment is common and the choice of procedures; scleral buckling, vitrectomy, pneumatic retinopexy or a combination of these vary, depending on the location, size of the detachment and the surgeon 2019. The presence of epiretinal membrane, paravascular retinal cysts, vascular microfolds, and tractional ILM detachment are characteristics of retinal detachment associated with myopia 2015…”

Section: Choroid/retinal Pigment Epithelium/sclera/retinamentioning

confidence: 99%

Posterior segment conditions associated with myopia and high myopia

Jagadeesh

Philip

Fedtke

et al. 2020

Clinical and Experimental Optometry

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Myopia, and especially high myopia, is associated with a number of posterior segment changes that are considered to be mostly a consequence of the increased axial elongation. This can result in mechanical strain, attendant vascular changes, stretching and thinning of tissues, and atrophy/deformation of tissues in later or more advanced stages. Such myopiarelated changes are observed as changes and/or abnormalities in the vitreous, choroid, retina and peripheral retina, sclera and/or optic disc. Although many of these changes are benign, at times they may be associated with significant vision impairment that either requires active intervention or may suggest future progression of the disease. This review systematically addresses the posterior segment conditions seen in myopic eyes, describes the features associated with the condition and details management pathways.

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Section: Choroid/retinal Pigment Epithelium/sclera/retinamentioning

confidence: 99%

Posterior segment conditions associated with myopia and high myopia

Jagadeesh

Philip

Fedtke

et al. 2020

Clinical and Experimental Optometry

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“…1 Increased severity of myopia significantly elevates the risk of developing sightthreatening ocular diseases, including myopic maculopathy, [2][3][4][5] glaucoma, [6][7][8] cataract, 9,10 and retinal detachment. 11,12 To reduce the risk of myopia-related pathologies in later life, a range of potential pharmaceutical and optical interventions have been investigated in an attempt to slow childhood myopia progression.…”

Section: Introductionmentioning

confidence: 99%

One‐year results of 0.01% atropine with orthokeratology (AOK) study: a randomised clinical trial

Tan

Choy

et al. 2020

Ophthalmic Physiologic Optic

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Purpose To report the 1‐year results of an investigation into whether there is an additive effect between 0.01% atropine and orthokeratology (ortho‐k), in a single‐masked, two‐arm, randomised controlled trial: Combined Atropine with Orthokeratology (AOK) for myopia control study (ClinicalTrials.gov number: NCT02955927). Methods Chinese children aged between 6 and 11 years with 1.00–4.00 D of myopia, astigmatism <2.50 D, and no more than 1.00 D anisometropia, were randomly assigned either to an AOK group or ortho‐k only (OK) group at a 1:1 ratio. Subjects in the AOK group instilled one drop of 0.01% atropine into each eye, 10 min before nightly wear of ortho‐k lenses. The primary outcome, axial elongation, was examined at 6‐monthly intervals, along with secondary outcomes including best‐corrected visual acuity (BCVA), manifest refraction, accommodation, pupil size, and corneal topography. Results 29 AOK and 30 OK subjects completed the 1‐year visit. The overall axial elongation rate was significantly slower in the AOK group than in the OK group (mean (S.D.), 0.07 (0.16) mm vs 0.16 (0.15) mm, respectively; p = 0.03). A significant between‐group difference in axial elongation was observed over the first 6‐month period only (p < 0.001), but not over the second period (p = 0.818). At the 1‐year visit, increases in mean (S.D.) mesopic and photopic pupil sizes in the AOK group were 0.64 (0.48) mm and 0.36 (0.34) mm, respectively, which were significantly higher than 0.10 (0.50) mm and 0.02 (0.28) mm in the OK group (p < 0.001). At the 6‐month visit, a significant moderate negative correlation was found between axial elongation and the increase in photopic pupil size (r = −0.42, p = 0.02) in the AOK group. Conclusions There is an additive effect between 0.01% atropine and ortho‐k over one year, with mean axial elongation in the AOK group 0.09 mm slower than that in the OK group. It appears that the additive effect was only during the first six months; a second‐year investigation is warranted to determine whether the effect is sustained over time.

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“…Second, the neuropsychiatric assessment was not conducted on patients with RD. Third, many predisposing factors of RD are common in the clinic; therefore, the VBM results of RD cannot be accurately evaluated (3–5).…”

Section: Discussionmentioning

confidence: 99%

“…Common risk factors for RD include high myopia, trauma, and cataract surgery, among others (3–5). Early symptoms of RD include acute-onset floaters and flashes of light, decreased central vision, visual distortion, and visual field defects (6).…”

Section: Introductionmentioning

confidence: 99%

Reduced gray matter volume in patients with retinal detachment: evidence from a voxel-based morphometry study

Liu

et al. 2019

Acta Radiol

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Background We know little about the pathogenesis and diagnosis of retinal detachment. Purpose To assess spontaneous changes in the cerebral cortex of patients with retinal detachment using voxel-based morphometry and to explore the relationship between retinal detachment and clinical behavioral performance. Material and Methods Patients (14 men, 6 women; average age = 49.15 ± 10.32 years) with rhegmatogenous retinal detachment (duration of 24.05 ± 19.61 days) and 20 matched healthy controls were recruited. All participants underwent repeated functional magnetic resonance imaging scans. The original three-dimensional T1 brain images were analyzed using voxel-based morphometry and whole brain white matter volume and whole brain gray matter volume were compared with those of the control group. A receiver operating characteristic (ROC) curve was used to classify the mean gray matter volume values of the patients with retinal detachment compared with the controls. Results Compared with the controls, whole brain gray matter volume was significantly reduced in patients with retinal detachment, as evidenced by changes in the right inferior frontal gyrus, right superior temporal gyrus, right anterior cingulate gyrus, and right cuneus. In addition, the posterior lobe of the cerebellum, left hippocampus, left cingulate gyrus, and left middle temporal gyrus were also obviously atrophied. Furthermore, whole brain white matter volume of the patients with retinal detachment showed a slight reduction. The ROC curve analysis of each brain region showed that the accuracy of the area under the curve was high. Conclusion We proved that patients with retinal detachment had unusual changes in the gray matter volume and white matter volume in vision-related brain regions, which could reveal potential pathological mechanisms of retinal detachment.

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Pediatric Retinal Detachment in an Asian Population With High Prevalence of Myopia

Cited by 19 publications

References 30 publications

Posterior segment conditions associated with myopia and high myopia

Posterior segment conditions associated with myopia and high myopia

One‐year results of 0.01% atropine with orthokeratology (AOK) study: a randomised clinical trial

Reduced gray matter volume in patients with retinal detachment: evidence from a voxel-based morphometry study

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