Pediatric reference intervals for 29 Ortho VITROS 5600 immunoassays using the CALIPER cohort of healthy children and adolescents

Higgins, Victoria; Fung, Angela W.S.; Chan, Man Khun; Macri, Joseph; Adeli, Khosrow

doi:10.1515/cclm-2017-0349

Cited by 25 publications

(17 citation statements)

References 41 publications

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“…This was particularly evident for progesterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and PTH. More recently, CALIPER established age-and sex-specific reference intervals for 29 immunoassays using Ortho VITROS 5600 assays [18]. Although the age and sex trends in analyte concentration were similar to those observed using Abbott and Beckman assays, some analyte concentrations were higher or lower overall.…”

Section: Biochemical and Endocrine Markers Measured By Immunoassaymentioning

confidence: 82%

“…The majority of direct reference interval studies used assays performed on Abbott ARCHITECT instrumentation, using the c8000 [9], the i2000 [10,12], or the ci4100 [14,17,20] model. Additional direct reference interval studies used LC-MS/MS [13,16], HPLC [15], UPLC [16], or Ortho VITROS 5.1 [16], Ortho VITROS 5600 [18] or Beckman Coulter DxI or Access 2 assays [11].…”

Section: Sample Analysismentioning

confidence: 99%

“…Refer to the original publication [11] for additional information. Refer to the original publication [18] for additional information.…”

Section: Fasting Versus Postprandial Blood Samplingmentioning

confidence: 99%

See 2 more Smart Citations

The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper

Adeli

Higgins

Trajcevski

et al. 2017

Critical Reviews in Clinical Laboratory Sciences

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Section: Biochemical and Endocrine Markers Measured By Immunoassaymentioning

confidence: 82%

Section: Sample Analysismentioning

confidence: 99%

See 1 more Smart Citation

The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper

Adeli

Higgins

Trajcevski

et al. 2017

Critical Reviews in Clinical Laboratory Sciences

Self Cite

208

203

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“…Furthermore, limited studies are available regarding the best time point for blood sampling after GnRH stimulation in Korean children [ 7 , 11 , 12 , 13 , 14 ]. Previous studies reported differences in hormone concentration ranges of LH and FSH in different ethnic populations using different analytical platforms [ 15 , 16 ]. Previous studies conducted to evaluate the best time point for blood sampling after GnRH agonist application in populations other than Korean used different doses of GnRH agonist, limited numbers of male subjects, different LH cut-off values, and different analytical platforms to diagnose CPP [ 6 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Time Points for Gonadotropin-Releasing Hormone Stimulation Test Results in Korean Children

Choi

Kwon

et al. 2021

JCM

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The gold standard for the laboratory diagnosis of central precocious puberty is based on the measurement of luteinizing hormone (LH) after gonadotropin-releasing hormone (GnRH) stimulation. We sought to investigate the laboratory data for GnRH stimulation testing using samples collected from Korean children at different time points. Sampling times were at the basal time point (0) and 15, 30, 45, 60, 90, and 120 min after GnRH stimulation. Pubertal response was defined as occurring when the peak LH concentration was 5 IU/L or more and rose to at least 2 times the basal LH concentration after GnRH stimulation. During the study period, 19,990 test results from 1958 Korean children (1841 females aged 1.3–8.9 years and 117 males aged 7.3–9.9 years) were obtained. Among the 1958 children, 1232 (62.9%) showed pubertal responses. The receiver operating characteristic curve that demonstrated the greatest area under the curve (AUC) among all examined time points was 45 min after GnRH stimulation in males (AUC 0.982, 95% CI 0.938–0.998) and 60 min in females (AUC 0.975, 95% CI 0.967–0.981). The combination of 45 min and 60 min showed the greatest AUC (0.996, 95% confidence interval 0.991–0.998), with a sensitivity level of 99.1% and a specificity of 100% for all children. The results of this study provide a possibility for a reduction in sampling time points (45 min and 60 min) to identify the presence of a pubertal response after GnRH stimulation in Korean children.

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“…Iron metabolism related laboratory indices including serum ferritin (SF), the most specific test that correlates with total body iron stores, as well as serum iron (SI) and total iron-binding capacity (TIBC), which is needed to calculate the transferrin saturation (TS) value. 4–6 In cases of iron deficiency, SF and iron concentrations fall with an increase in TIBC and a reduction in TS.…”

Section: Introductionmentioning

confidence: 99%

Changes of iron metabolism during pregnancy and the establishment of reference intervals for pregnant Chinese women

et al. 2019

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Background Abnormalities of iron metabolism in pregnancy pose risks for maternal and fetal health. Robust reference intervals for iron metabolism indices have not been established in a pregnant Chinese population. The purpose of this study was to derive reference intervals for indices of iron metabolism during pregnancy in a Chinese population. Methods A total of 360 healthy pregnant women were recruited and divided into three groups of 120 by gestational age: first trimester (1–13 weeks), second trimester (14–27 weeks) and third trimester (≥28 weeks). An additional 120 healthy non-pregnant women were recruited as the non-pregnant control group. Serum ferritin was measured by electrochemiluminescence immunoassay. Serum iron and total iron-binding capacity were measured by a direct bathophenanthroline method. Transferrin saturation value was calculated with formula TS = SI/TIBC. The reference intervals were established using a non-parametric method. Results In first and second trimesters (combined), the reference intervals for serum ferritin, serum iron, total iron-binding capacity and transferrin saturation are 14.7–184.3 mg/L, 14.50–33.45 µmol/L, 36.53–68.81 µmol/L and 19.04–64.76%, respectively. In the third trimester, the reference intervals for serum ferritin, serum iron, total iron-binding capacity and transferrin saturation are 7.2–122.2 mg/L, 5.83–21.52 µmol/L, 49.40–122.76 µmol/L and 8.22–52.75%, respectively. Conclusion The reference intervals for iron metabolism indices for healthy pregnant Chinese women were established in accordance with CLSI C28-A3 guidelines. This will be a valuable tool for clinical practice and research.

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Pediatric reference intervals for 29 Ortho VITROS 5600 immunoassays using the CALIPER cohort of healthy children and adolescents

Cited by 25 publications

References 41 publications

The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper

The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper

Time Points for Gonadotropin-Releasing Hormone Stimulation Test Results in Korean Children

Changes of iron metabolism during pregnancy and the establishment of reference intervals for pregnant Chinese women

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