The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper

Adeli, Khosrow; Higgins, Victoria; Trajcevski, Karin E.; Habeeb, Nicole White-Al

doi:10.1080/10408363.2017.1379945

Cited by 211 publications

(233 citation statements)

References 49 publications

(104 reference statements)

Supporting

Mentioning

203

Contrasting

Unclassified

Order By: Relevance

“…Notably, very few subjects were studied in the age interval below 6 months. Compared to more recent studies such as the CALIPER study [14] that primarily used data from an outpatient clinics population, our data is based on a supposedly healthy community population. Our observed reference interval lower limits for infants are similar to those suggested by the ESPGHAN Committee on Nutrition [15] but our data suggest that that reference interval age stratifications are needed for even more time intervals during infancy.…”

Section: Discussionmentioning

confidence: 99%

When age really matters; ferritin reference intervals during infancy revisited

Larsson

Hillarp

Hellström‐Westas

et al. 2019

Scandinavian Journal of Clinical and Laboratory Investigation

View full text Add to dashboard Cite

Infants are at risk for iron deficiency. Despite research advances, assessing iron stores during infancy remains a challenge to the clinician. Ferritin is the first-choice laboratory marker for measuring iron stores but it is today still unclear how to evaluate reference intervals among infants. We have studied Swedish infants (n ¼ 456), born at term after normal pregnancies. Ferritin was measured at birth (umbilical cord sample), 48-72 h, 4 months and 12 months. Lower and upper reference interval limits were constructed as the 2.5th and 97.5th percentiles. By a large study population, we were able to use more stringent measures to avoid interference from the acute phase response than previous reports on ferritin reference intervals. When we used mathematical transformation we furthermore avoided potential information loss in precision and confirmed earlier reports of sex differences. At the lower reference interval limits there were small differences between sexes. For the higher limits, the differences were more pronounced in the older infant. At 0-3 d of age we observed a difference between the sexes of only 5% at the upper limits. The differences peaked at 12 months, where the boys' upper 97.5th percentile was 56% compared to girls.

show abstract

Section: Discussionmentioning

confidence: 99%

When age really matters; ferritin reference intervals during infancy revisited

Larsson

Hillarp

Hellström‐Westas

et al. 2019

Scandinavian Journal of Clinical and Laboratory Investigation

View full text Add to dashboard Cite

show abstract

“…Different countries or regions usually establish corresponding RIs for their local populations. However, it is not easy to establish accurate age and sex‐specific RIs in paediatric populations using samples from healthy children due to various reasons . In 2012, the Ministry of Health of the People's Republic of China issued the “Reference Intervals for Blood Cell Analysis,” establishing the standard for the health industry in adults.…”

Section: Introductionmentioning

confidence: 99%

“…However, it is not easy to establish accurate age and sex-specific RIs in paediatric populations using samples from healthy children due to various reasons. [2][3][4] In 2012, the Ministry of Health of the People's Republic of China issued the "Reference Intervals for Blood Cell Analysis," 5 establishing the standard for the health industry in adults. To date, the corresponding industry standard in children has not been determined.…”

mentioning

confidence: 99%

Establishment of reference intervals for complete blood count parameters in venous blood for children in the Xiamen area, China

Zhang

Huang

et al. 2019

Int J Lab Hematology

View full text Add to dashboard Cite

Objectives To observe changes in the complete blood count (CBC) venous blood parameters of healthy children and establish appropriate reference intervals (RIs). Methods Overall, 4066 healthy children were selected and divided into four groups: infants, toddlers, preschool‐age children and school‐age children. Venous blood was analysed for 17 parameters. Outlier data for each parameter were eliminated and RIs were established based on the Clinical and Laboratory Standards Institute C28‐A3c guideline. Results The RIs for certain parameters differed among the different age groups. The white blood cell (WBC) count differed among the four age groups. The variation trends for absolute neutrophil count in all age groups were opposite to those for WBC and absolute lymphocyte count. The mean absolute eosinophil count values were significantly higher in the infant group than in the other groups. The RIs for red blood cell were identical across all age groups except in infants. The mean Hb level for infants was significantly lower than that for the other age groups. The mean and RI for platelet count were significantly higher in the infant group than in the other groups. Conclusions There are dynamic variations in the values reported for measurements of most CBC parameters in children. Hence, such results should always be interpreted according to the child's age. Thus establishing appropriate RIs for different age groups in paediatrics is essential.

show abstract

“…Additionally, the CALIPER project was conducted among a much larger study group than the following study. The differences in lipid concentration levels may result from the difference in age ranges and the strictly standardised meal used in the CALIPER study [10]. Boyd et al demonstrated that obesity and hypertension occurring in childhood have a negative impact on the lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

The cut-off values for non-fasting routine lipid parameters in presumably healthy 9–11-year-old children

Szternel

Kwasigroch

Murawska

et al. 2018

Medical Research Journal

View full text Add to dashboard Cite

Disorders of lipid metabolism cause accelerated atherosclerosis and increase cardiovascular risk, which is why lipid profile screening, especially at a young age, should be widely applied. Aim. The aim of the study was to determine the cutoff points for non-fasting lipid parameters in presumably healthy children aged 9-11 years. Material and methods. The study was performed with the use of blood samples taken in non-fasting state from 289 school children of both sexes (152 girls and 137 boys). Routine lipid profile was assessed: TC, LDL-C, HDL-C, and triglycerides. Laboratory measurements were performed in serum samples using a biochemical autoanalyser. Results. In this study we determined the 97.5 percentile values for TC, LDL-C, and triglycerides and the 2.5 percentile values for HDL-C. The upper cutoffs for TC, LDL-C, and triglycerides were found to be 239 mg/dL, 163 mg/dL, and 284 mg/dL, respectively, and the lower cutoff for HDL-C was 37 mg/dL. Conclusions. The upper range of non-fasting total cholesterol was higher by about 30 mg/dL compared to fasting state for a similar age range; the cutoff points in non-fasting children for LDL-C and TG were also higher. The lower cutoff for HDL-C was similar compared to fasting state for the respective age range. The determination of the non-fasting cutoff values for routine lipid profile in the paediatric population is essential for the proper evaluation of the cardiovascular risk because using the reference values for adults may cause an incorrect interpretation of the laboratory results.

show abstract

The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper

Cited by 211 publications

References 49 publications

When age really matters; ferritin reference intervals during infancy revisited

When age really matters; ferritin reference intervals during infancy revisited

Establishment of reference intervals for complete blood count parameters in venous blood for children in the Xiamen area, China

The cut-off values for non-fasting routine lipid parameters in presumably healthy 9–11-year-old children

Contact Info

Product

Resources

About