Pediatric Multiple Sclerosis

Filippi, Massimo; Rocca, Maria

doi:10.1007/978-3-030-38621-4_2

Cited by 1 publication

(2 citation statements)

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“…The prevalence of PedMS in Serbia is 4.4/100 000, while the prevalence in the entire Serbian population is 0.77/100 000. Other PedMS studies showed incidence ranging from 0.13/100,000 to 1.24/100,000 [7] and prevalence of 5.5 to 26.92 [4]. Our results showed lower prevalence in comparison to the population of Sardinia [13] and Kuwait [14] and similar to Dutch [15] and Slovenian [16] studies.…”

Section: Discussionsupporting

confidence: 83%

“…Similar to the adult MS, the etiology of PedMS, has not been fully elucidated; however, it is known to be a multifactorial disease as a result of numerous genetic interactions and environmental factors [1]. According to previously published data, a positive family history is present in more than 6% of patients with PedMS, with female sex predominance and female to male ratio of 2:1 up to 3:1 [7].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Characteristics of pediatric multiple sclerosis: A tertiary referral center study

Nikolić¹,

Ivančević²,

Zaletel

et al. 2020

PLoS ONE

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Objective The present study represents one of the largest series of pediatric multiple sclerosis (PedMS) in Western Balkan region. This is the first study aimed to evaluate the characteristics of PedMS in the Serbian population. Methods This retrospective study on 54 PedMS, aged 7–17 years, was performed at the Clinic of Neurology and Psychiatry for Children and Youth in Belgrade, Serbia, a tertiary center for the diagnosis and treatment of children with neurological and psychiatric diseases. Results Female to male ratio was 37 (68.5%): 17 (31.5%). Family history of MS was noted in 9.3% and autoimmune diseases in 24.1% patients. Co-occurring migraine was in 7,4%. Monofocal onset of disease was present in 77.8% patients. The most common initial symptoms were optic neuritis (37%), sensory disturbances (31.5%), motor deficit (24.1%), cerebellar (18.5%) and brainstem lesions (16.7%), pain (9.3%), acute disseminated encephalomyelitis like symptoms (1.9%), and hearing loss (3.7%). Visual evoked potentials were pathological in 75.9% of patients. Oligoclonal bands were positive in 68.5% of patients. Magnetic resonance imaging showed periventricular (94.4%), infratentorial (77.8%), juxtacortical and cortical changes (55.6%) and changes in the cervical spinal cord (33.3%). The median EDSS score was 2.0. Conclusion Our cohort significantly differs from the literature data regarding more frequent occurrence of optic neuritis, hearing loss as a first symptom, the relapsing-remitting course of the disease, higher proportion of early onset of disease, presence of co-occurring migraine and the frequent occurrence of epilepsy and other autoimmune diseases in the family.

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