Characteristics of pediatric multiple sclerosis: A tertiary referral center study

Abstract

Objective The present study represents one of the largest series of pediatric multiple sclerosis (PedMS) in Western Balkan region. This is the first study aimed to evaluate the characteristics of PedMS in the Serbian population. Methods This retrospective study on 54 PedMS, aged 7–17 years, was performed at the Clinic of Neurology and Psychiatry for Children and Youth in Belgrade, Serbia, a tertiary center for the diagnosis and treatment of children with neurological and psychiatric diseases. Results Female to male ratio was 37 (68.5%): 17 (31.5%). Family history of MS was noted in 9.3% and autoimmune diseases in 24.1% patients. Co-occurring migraine was in 7,4%. Monofocal onset of disease was present in 77.8% patients. The most common initial symptoms were optic neuritis (37%), sensory disturbances (31.5%), motor deficit (24.1%), cerebellar (18.5%) and brainstem lesions (16.7%), pain (9.3%), acute disseminated encephalomyelitis like symptoms (1.9%), and hearing loss (3.7%). Visual evoked potentials were pathological in 75.9% of patients. Oligoclonal bands were positive in 68.5% of patients. Magnetic resonance imaging showed periventricular (94.4%), infratentorial (77.8%), juxtacortical and cortical changes (55.6%) and changes in the cervical spinal cord (33.3%). The median EDSS score was 2.0. Conclusion Our cohort significantly differs from the literature data regarding more frequent occurrence of optic neuritis, hearing loss as a first symptom, the relapsing-remitting course of the disease, higher proportion of early onset of disease, presence of co-occurring migraine and the frequent occurrence of epilepsy and other autoimmune diseases in the family.

Interim guidelines for the assessment and treatment of pain in children with multiple sclerosis

“…Multiple sclerosis (MS) is an autoimmune disease associated with demyelination, neurodegeneration, and chronic inflammation of the central nervous system ( Vargas-Lowy and Chitnis, 2012 ; Filippi et al, 2016 ; Brenton et al, 2020 ). While most often diagnosed in adulthood, approximately 2–10% of individuals with MS experience their first clinical symptom(s) before age 18 ( Vargas-Lowy and Chitnis, 2012 ; Jancic et al, 2016 ; Narula, 2016 ; Nikolić et al, 2020 ).…”