Pediatric malignant salivary gland tumors: 60 year follow up

Incidence of head and neck cancer in children: A Danish nationwide study from 1978 to 2014

“…Of the nine cases, five children were 14 years or less, and of these the most frequent histological type was mucoepidermoid carcinoma, as described by our study . Fortunately, pediatric salivary gland tumors often have a favorable prognosis as they are typically identified at an early stage and are most often low grade . Interestingly, the incidence of salivary gland cancer among children and adults has remained stable in Denmark from 1990 to 2005 …”

Survival and characteristics of pediatric salivary gland cancer: A systematic review and meta‐analysis

“…One study found that high‐grade SGCs in children were more likely to have a recurrence and have a higher mortality . A few studies also noted that tumor enucleations typically led to recurrence . Cockerill et al noted that 10 of 14 local recurrences occurred after initial tumor enucleations and in children where neck dissection was not performed .…”

Mandibular growth in survivors of pediatric parotid gland carcinoma treated with interstitial brachytherapy

“…The rates of nodal involvement and systematic metastasis are relatively lower in the pediatric population than is the case for salivary gland carcinomas in the adult population . Surgery is the mainstay treatment, but the effects of radiotherapy are unclear . Nevertheless, adjunctive radiotherapy may be indicated for high‐risk cases, including tumors with high grades, perineural invasion, incomplete resection, or nodal involvement .…”

“…2,3 Moreover, about half of the parotid gland tumors are malignant in the pediatric population; 3 of these, mucoepidermoid carcinoma is the most common. 1,[3][4][5] Nevertheless, pediatric patients with this malignancy have favorable prognosis, with 5 year overall survival above 80%. 1,[4][5][6][7][8][9] The rates of nodal involvement and systematic Abbreviations: 3D, three dimensional; BTPS, brachytherapy treatment planning system; cGy, centigray; CT, computed tomography; CTV, clinical target volume; D90, the dose delivered to 90% of the target volume; Gy, gray; MBq, megabecquerels; mm 3 , cubic millimeter; V100, the percentage of the target volume receiving at least 100% of the prescription dose metastasis are relatively lower in the pediatric population than is the case for salivary gland carcinomas in the adult population.…”

“…1,[4][5][6][7][8][9] The rates of nodal involvement and systematic Abbreviations: 3D, three dimensional; BTPS, brachytherapy treatment planning system; cGy, centigray; CT, computed tomography; CTV, clinical target volume; D90, the dose delivered to 90% of the target volume; Gy, gray; MBq, megabecquerels; mm 3 , cubic millimeter; V100, the percentage of the target volume receiving at least 100% of the prescription dose metastasis are relatively lower in the pediatric population than is the case for salivary gland carcinomas in the adult population. 1,4 Surgery is the mainstay treatment, but the effects of radiotherapy are unclear. [2][3][4] Nevertheless, adjunctive radiotherapy may be indicated for high-risk cases, including tumors with high grades, perineural invasion, incomplete resection, or nodal involvement.…”