Pediatric hemorrhagic cystitis

Decker, Daniel B.; Karam, Jose A.; Wilcox, Duncan T.

doi:10.1016/j.jpurol.2009.02.199

Cited by 68 publications

(118 citation statements)

References 89 publications

(95 reference statements)

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“…20 As this treatment has been used successfully in patients with HC after pelvic radiotherapy, 17 --19 it may benefit patients with HC after HSCT. 5,10,11 To date, there have been a few case reports of successful HBO therapy in pediatric 13,15 and adult 12,14,16 patients. HBO showed a cure rate of 78.5% in pediatric patients with BKV-associated HSCT.…”

Section: Discussionmentioning

confidence: 99%

“…4 Other potential risk factors include acute GvHD, use of busulfan or total-body irradiation in preparative regimens and older age. 2 Many patients with HC can be treated with hyperhydration and platelet transfusions, 5 but those refractory to these treatments may require further measures, including the administration of prostaglandins, alum, formalin, estrogens, epidermal growth factor, and recombinant human granulocytemacrophage colony-stimulating factor. 6 --9 Patients with viral infection may be treated with anti-viral agents, but their efficacy is limited.…”

Section: Introductionmentioning

confidence: 99%

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Clinical effectiveness of hyperbaric oxygen therapy for BK-virus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation

Savva-Bordalo

Vaz

Sousa

et al. 2011

Bone Marrow Transplant

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Late-onset hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (HSCT) has been associated with BK virus (BKV). Antiviral drugs are of limited efficacy and the optimal treatment for HC has not yet been established. Hyperbaric oxygen (HBO) may benefit these patients. We, therefore, retrospectively evaluated the effectiveness of HBO therapy in 16 patients with HC after allogeneic HSCT. All 16 patients had macroscopic hematuria and BKV infection. Patients received 100% oxygen in a hyperbaric chamber at 2.1 atmospheres for 90 min, 5 days per week, with a median 13 treatments (range, 4 --84). Fifteen patients (94%) showed complete resolution of hematuria. Median urinary DNA BKV titers declined after HBO (Po0.05). Patients started on HBO earlier after diagnosis of HC responded sooner (Po0.05). HBO was generally well tolerated and proved to be a reliable option for this difficult to manage condition.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical effectiveness of hyperbaric oxygen therapy for BK-virus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation

Savva-Bordalo

Vaz

Sousa

et al. 2011

Bone Marrow Transplant

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“…Early-onset HC occurs within 1 week after HSCT and is mostly a symptom of regimen-related toxicity. Lateonset HC usually occurs after engraftment and is associated with viral infections, including those caused by the human polyomavirus BK (BKV), polyomavirus JC, adenovirus (AdV), and cytomegalovirus (CMV) [4]. BKV is the most frequent cause of late-onset HC and affects 5.3% to 21.2% of children undergoing HSCT [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Choreito Formula for BK Virus–associated Hemorrhagic Cystitis after Allogeneic Hematopoietic Stem Cell Transplantation

Kawashima

Ito

Sekiya

et al. 2015

Biology of Blood and Marrow Transplantation

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Therapy for BK virus (BKV)-associated hemorrhagic cystitis (BKV-HC) is limited after hematopoietic stem cell transplantation (HSCT). We examined whether choreito, a formula from Japanese traditional Kampo medicine, is effective for treating BKV-HC. Among children who underwent allogeneic HSCT between October 2006 and March 2014, 14 were diagnosed with BKV-HC (median, 36 days; range, 14 to 330 days) after HSCT, and 6 consecutive children received pharmaceutical-grade choreito extract granules. The hematuria grade before treatment was significantly higher in the choreito group than in the nonchoreito group (P = .018). The duration from therapy to complete resolution was significantly shorter in the choreito group (median, 9 days; range, 4 to 17 days) than in the nonchoreito group (median, 17 days; range, 15 to 66 days; P = .037). In 11 children with macroscopic hematuria, the duration from treatment to resolution of macroscopic hematuria was significantly shorter in the choreito group than in the nonchoreito group (median, 2 days versus 11 days; P = .0043). The BKV load in urine was significantly decreased 1 month after choreito administration. No adverse effects related to choreito administration were observed. Choreito may be a safe and considerably promising therapy for the hemostasis of BKV-HC after HSCT.

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“…HBO was introduced to improve the clinical state after radiation of various organs, including the bladder [5,[15][16][17]. Sufficient HBO therapy was described in both adult and pediatric patients [18,19]. Savva-Bordalo et al [2] presented 16 patients with HC after alloHSCT who underwent successful HBO treatment with reduction of hematuria.…”

Section: Discussionmentioning

confidence: 99%

The use of hyperbaric oxygen therapy in the treatment of hemorrhagic cystitis after allogeneic stem cell transplantation from an unrelated donor

et al. 2015

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Hemorrhagic cystitis (HC) is a diffuse inflammation of the bladder of an infectious or non-infectious etiology, causing bleeding of the bladder mucosa. There are no explicit guidelines defining the appropriate treatment of HC. Hyperbaric oxygen therapy (HBO) is a non-invasive method involving the use of 100 % oxygen under increased pressure, which penetrates to poorly perfused areas. The most appropriate group for treatment with HBO is patients with BK virus-associated HC after allogenic human stem cell transplantation (alloHSCT). In this report, we present five patients after alloHSCT from a matched unrelated donor with symptoms of HC successfully treated with HBO. All patients received therapy with 100 % oxygen in a hyperbaric chamber at 2.5 atmospheres for 60 min, delivered 5 days per week. Complete response with resolution of pain and hematuria, as well as eradication of viral load, was achieved by all the patients after a mean of 13 sessions (range 11-30) of HBO. These data indicate that HBO therapy is sufficient and effective in the treatment of HC, and represents a well-tolerated procedure with good clinical and laboratory results after ineffective primary treatment.

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Pediatric hemorrhagic cystitis

Cited by 68 publications

References 89 publications

Clinical effectiveness of hyperbaric oxygen therapy for BK-virus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation

Clinical effectiveness of hyperbaric oxygen therapy for BK-virus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation

Choreito Formula for BK Virus–associated Hemorrhagic Cystitis after Allogeneic Hematopoietic Stem Cell Transplantation

The use of hyperbaric oxygen therapy in the treatment of hemorrhagic cystitis after allogeneic stem cell transplantation from an unrelated donor

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