The use of hyperbaric oxygen therapy in the treatment of hemorrhagic cystitis after allogeneic stem cell transplantation from an unrelated donor

Urbaniak-Kujda, Donata; Kapelko-Słowik, Katarzyna; Biernat, Monika; Dybko, Jarosław; Laszkowska, Magdalena; Kuliczkowski, Kazimierz

doi:10.1007/s12185-015-1832-y

Cited by 8 publications

(7 citation statements)

References 19 publications

(30 reference statements)

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“…In refractory cases the treatment options are mainly surgical and include selective embolization of bladder arteries, bilateral nephrostomy and cystectomy. Hyperbaric oxygen therapy is also an option for refractory cases [105].…”

Section: Viral Infectionsmentioning

confidence: 99%

An overview of infectious complications after allogeneic hematopoietic stem cell transplantation

Şahin

Toprak

Atilla

et al. 2016

Journal of Infection and Chemotherapy

182

163

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Infections are the most common and significant cause of mortality and morbidity after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The presence of neutropenia and mucosal damage are the leading risk factors in the early pre-engraftment phase. In the early post-engraftment phase, graft versus host disease (GvHD) induced infection risk is increased in addition to catheter related infections. In the late phase, in which reconstitution of cellular and humoral immunity continues, as well as the pathogens seen during the early post-engraftment phase, varicella-zoster virus and encapsulated bacterial infections due to impaired opsonization are observed. An appropriate vaccination schedule following the cessation of immunosuppressive treatment after transplantation, intravenous immunoglobulin administration, and antimicrobial prophylaxis with penicillin or macrolide antibiotics during immunosuppressive treatment for GvHD might decrease the risk of bacterial infections. Older age, severe mucositis due to toxicity of chemotherapy, gastrointestinal tract colonization, prolonged neutropenia, unrelated donor and cord blood originated transplantations, acute and chronic GvHD are among the most indicative clinical risk factors for invasive fungal infections. Mold-active anti-fungal prophylaxis is suggested regardless of the period of transplantation among high risk patients. The novel serological methods, including Aspergillus galactomannan antigen and beta-D-glucan detection and computed tomography are useful in surveillance. Infections due to adenovirus, influenza and respiratory syncytial virus are encountered in all phases after allo-HSCT, including pre-engraftment, early post-engraftment and late phases. Infections due to herpes simplex virus-1 and -2 are mostly seen during the pre-engraftment phase, whereas, infections due to cytomegalovirus and human herpes virus-6 are seen in the early post-engraftment phase and Epstein-Barr virus and varicella-zoster virus infections often after +100th day. In order to prevent mortality and morbidity of infections after allo-HSCT, the recipients should be carefully followed-up with appropriate prophylactic measures in the post-transplant period.

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Section: Viral Infectionsmentioning

confidence: 99%

An overview of infectious complications after allogeneic hematopoietic stem cell transplantation

Şahin

Toprak

Atilla

et al. 2016

Journal of Infection and Chemotherapy

182

163

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“…Savva-Bordalo et al reported similar findings with clinical resolution of hematuria in 94% of the 16 patients they treated with HBOT [20]. To date, there continues to be growing evidence of HBOT being an adjunctive therapy for patients with BK virus-associated HC after SCT [14,20,21,27]. Although the primary reason for using HBOT, in this case, was due to persistent HC despite standard of care therapy [20], it is also the third reported case in the United States, to the authors' knowledge, and provides added support as an option for HBOT in these cases.…”

Section: Discussionmentioning

confidence: 77%

Hyperbaric Oxygen Therapy of an Adolescent Stem Cell Transplantation Recipient with Hemorrhagic Cystitis and BK Virus

López

Alismail

Tan

2020

Case Reports in Pulmonology

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Hyperbaric oxygen therapy (HBOT) continues to show effectiveness in the treatment of several diseases and benefits such as fibroblast proliferation, capillary angiogenesis, and decreasing edema, especially in hemorrhagic cystitis (HC). We report a case of a 15-year-old male with chronic myelogenous leukemia status posthaploidentical stem cell transport with BK virus in the United States to be treated by HBOT. The patient received a total of 30 HBOT treatments for 90 minutes at 2 ATA. After HBOT treatments, patient showed signs of improvements such as cessation of hemorrhage cystitis. The findings of this case support and shows that there is growing evidence for the use of HBOT as adjunctive therapy for patients with BK virus associated with HC after stem cell transplantation.

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“…Cyclophosphamide hemorrhagic cystitis is defined by inflammation of the bladder from an infectious or non-infectious etiology. 22 Its causative agent, acrolein, is a metabolite of cyclophosphamide, and symptoms include recurrent hematuria, urinary urgency, and suprapubic pain. 23 The role of HBOT in cyclophosphamide hemorrhagic cystitis is to enhance angiogenesis, reduce bleeding caused by vasoconstriction, help optimize immune function at the cellular level, and stimulate granulation tissue formation.…”

Section: B Laddermentioning

confidence: 99%

“…25 26 Additionally, it has been postulated that HBOT may reduce BK viremia and viruria associated with cyclophosphamide hemorrhagic cystitis. 22 …”

Section: B Laddermentioning

confidence: 99%

Clinical utility of hyperbaric oxygen therapy in genitourinary medicine

et al. 2018

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Hyperbaric oxygen therapy (HBOT) is a medical technique which delivers oxygen at ambient pressures to increase the amount of dissolved oxygen in the blood and oxygen distribution to tissues. There are several beneficial properties of HBOT concomitant with elevated oxygen distribution in tissue including anti-inflammation, angiogenesis through vascular endothelial growth factor proliferation, augmented fibroblast activity through fibroblast growth factor proliferation, tissue and wound repair, enhancement of lymphocyte and macrophage activity, increased male testosterone secretion, and bactericidal activity. Given its renown in treating conditions such as decompression sickness and carbon monoxide poisoning, HBOT is making gradual strides for use in genitourinary medicine due to its low risk and likeliness to achieve favorable results. Early success has been observed in the treatment of Fournier's gangrene, radiation cystitis, and interstitial cystitis via the elimination of clinical symptoms such as pain. Further indications that have exhibited positive outcomes despite HBOT's ambiguous mechanism of action include cyclophosphamide hemorrhagic cystitis, emphysematous cystitis, pelvic radiation disease, radiation-induced proctopathy, dystrophic calcification of the prostate, erectile dysfunction secondary to urethroplasty, priapism, abnormal renal morphology, blood testosterone, calcific uremic arteriolopathy, and hidradenitis suppurativa. For other indications, multicenter studies must be conducted to determine HBOT's true efficacy, mechanism of action, risks, and advantages over conventional treatments.

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The use of hyperbaric oxygen therapy in the treatment of hemorrhagic cystitis after allogeneic stem cell transplantation from an unrelated donor

Cited by 8 publications

References 19 publications

An overview of infectious complications after allogeneic hematopoietic stem cell transplantation

An overview of infectious complications after allogeneic hematopoietic stem cell transplantation

Hyperbaric Oxygen Therapy of an Adolescent Stem Cell Transplantation Recipient with Hemorrhagic Cystitis and BK Virus

Clinical utility of hyperbaric oxygen therapy in genitourinary medicine

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