Pediatric Heart Transplantation: Transitioning to Adult Care (TRANSIT): Feasibility of a Pilot Randomized Controlled Trial

Grady, Kathleen L.; Andrei, Adin Cristian; Shankel, T.; Chinnock, Richard; Miyamoto, Shelley D.; Ambardekar, Amrut V.; Anderson, Allen S.; Addonizio, Linda J.; Latif, F.; Lefkowitz, Debra S.; Goldberg, Lee R.; Hollander, Seth A.; Pham, Michael; Hof, Kathleen Van't; Weissberg‐Benchell, Jill; Yancy, Clyde W.; Liu, Menghan; Melody, Nichole; Pahl, Elfriede

doi:10.1016/j.cardfail.2019.06.011

Cited by 20 publications

(31 citation statements)

References 46 publications

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“…In contrast, the coordinator asked those in the control arm only whether they had any questions. The intervention had no significant effect on adherence [45]. The authors suggested that the lack of significant findings might be because of the study's small sample size, the lack of monitoring of attentiveness during the intervention, and high baseline adherence [45].…”

Section: Transfer Clinic Programsmentioning

confidence: 97%

“…Some transition clinics studied were based solely on educational interventions [44,45]. One study used an education-based intervention for pediatric heart transplant patients transferring to adult care [44].…”

Section: Transfer Clinic Programsmentioning

confidence: 99%

“…Recently, the possibility of providing virtual content has been explored [45]. Grady et al [45] piloted a transition clinic for cardiac heart transplant patients transferring to adult care. The transition clinic included online modules with quizzes that patients completed after each module.…”

Section: Transfer Clinic Programsmentioning

confidence: 99%

“…The intervention had no significant effect on adherence [45]. The authors suggested that the lack of significant findings might be because of the study's small sample size, the lack of monitoring of attentiveness during the intervention, and high baseline adherence [45]. It is thus unclear whether similar interventions that include virtual content may be effective.…”

Section: Transfer Clinic Programsmentioning

confidence: 99%

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Adherence to Medication During Transition to Adult Services

et al. 2020

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The transition from childhood and adolescence to adulthood is often tumultuous. For individuals with a chronic medical condition, this progression also includes a gradual transition to independence in healthcare management as well as a transfer in care location at some set point. As adolescents navigate these sometimes challenging processes, there is a significant risk for a decline in adequate health behaviors, which can have dire consequences. One of the most vital components of the transfer to adult care is medication adherence. Poor medication adherence puts patients at risk for worse outcomes, with the most profound being increased mortality for many conditions. In recent years, acknowledgment of the need to create evidencebased methods to aid patients during the transition period has been growing. This paper seeks to provide an overview of current research and recommendations for interventions to increase adherence to medication regimens during this period.

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Section: Transfer Clinic Programsmentioning

confidence: 97%

Section: Transfer Clinic Programsmentioning

confidence: 99%

Section: Transfer Clinic Programsmentioning

confidence: 99%

Section: Transfer Clinic Programsmentioning

confidence: 99%

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Adherence to Medication During Transition to Adult Services

et al. 2020

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“…Based upon the results from these systematic reviews, the effectiveness of adherence-enhancing interventions on immunosuppressive therapy was expanded as achieved with adopting RCTs. In specific, three RCTs (Han et al, 2019;Levine et al, 2019;Geramita et al, 2020) adopted the mobile health or smartphone app as the main interventions to manage the immunosuppressive medication adherence in lung or kidney recipients, while Grady et al conducted a pilot RCT study to determine whether a transition intervention could increase medication adherence in young heart transplant recipients (Grady et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Adherence-Enhancing Interventions for Immunosuppressive Therapy in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials

Shi

Liu

et al. 2020

Front. Pharmacol.

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Background: Immunosuppressant non-adherence is a widespread problem among solid organ recipients. With the newly published clinical trials, the randomized controlled trials (RCTs) based systematic review of adherence-enhancing interventions on immunosuppressant adherence in solid organ recipients has not been completed. In this systematic review and meta-analysis, we compared the efficacy of adherenceenhancing interventions versus routine intervention, as performed with RCTs, on immunosuppressant adherence in solid organ transplantation recipients.Methods: PubMed, Embase, Cochrane Library, CINAHL full text, and PsycINFO were searched from database inception to December 2019. This review was conducted following the PRISMA's reporting guidelines and according to the principles recommended by Cochrane Handbook for Systematic Review.Results: The search yielded 10,479 articles. A total of 27 articles (26 studies) with 715 participants were included in our analysis. Results from the meta-analysis revealed that as compared with that of the routine intervention group, the rates of overall adherence, dosing adherence, and timing adherence were significantly increased within the adherence-enhancing intervention group, with the pooled risk ratio (RR) of overall adherence = 1.17, [95% confidence interval (CI): 1.07 to 1.28; p = 0.0006]; RR of dosing adherence = 1.21 (95% CI: 1.08 to 1.36, p = 0.001); RR of timing adherence = 1.16 (95% CI: 1.03 to 1.29, p = 0.01). There was a significantly increased adherence score in the adherence-enhancing intervention group; however, no statistical significance on the immunosuppressant blood concentration was found between the two study groups.

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Advancing Knowledge in Pediatric Heart Failure—the Growing Pains

Jean‐St‐Michel

Marelli

2019

Journal of Cardiac Failure

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Pediatric Heart Transplantation: Transitioning to Adult Care (TRANSIT): Feasibility of a Pilot Randomized Controlled Trial

Cited by 20 publications

References 46 publications

Adherence to Medication During Transition to Adult Services

Adherence to Medication During Transition to Adult Services

Efficacy of Adherence-Enhancing Interventions for Immunosuppressive Therapy in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials

Advancing Knowledge in Pediatric Heart Failure—the Growing Pains

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