Pediatric bipolar disorder: evidence for prodromal states and early markers

Luby, Joan L.; Navsaria, Neha

doi:10.1111/j.1469-7610.2010.02210.x

Cited by 80 publications

(82 citation statements)

References 88 publications

(103 reference statements)

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“…1 There is increasing agreement on clinical phenotypes of children and adolescents who are at elevated risk for progression to fully syndromal BD. [2][3] Among children of parents with BD, subthreshold "high-risk" forms of the disorder can be detected as many as 10 years prior to onset of BD I or II. 3 Significant controversies exist about the diagnostic boundaries of early-onset BD, but agreement is substantial that BD and its subthreshold antecedents have a considerable impact on general functioning and quality of life.…”

Section: Introductionmentioning

confidence: 99%

Early Intervention for Symptomatic Youth at Risk for Bipolar Disorder: A Randomized Trial of Family-Focused Therapy

Miklowitz

Schneck

Singh

et al. 2015

FOC

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DisclosuresDr. Miklowitz has received research funding from the National Institute of Mental Health (NIMH), the National Association for Research on Schizophrenia and Depression (NARSAD), the Danny Alberts Foundation, the Attias Family Foundation, and the Robert L. Sutherland Foundation; and royalties from Guilford Press and John Wiley and Sons. Dr. Schneck has received funding from the Crowne Family Foundation. Dr. Cosgrove has received funding from the Lucille Packard Foundation for Children's Health, Spectrum Child Health, and the Klingenstein Third Generation Foundation. Dr. Garber has received funding from NIMH and the William T. Grant Foundation. Dr. Chang has received research funding from NIMH, NARSAD, Merck, and GlaxoSmithKline; and is a non-paid consultant for GlaxoSmithKline, Eli Lilly and Company, Bristol-Myers Squibb, and Merck. Drs. Singh, Taylor, George, Dickinson, and Ms. Howe report no biomedical financial interests or potential conflicts of interest.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptObjective-Depression and brief periods of (hypo)mania are linked to an increased risk of progression to bipolar I or II disorder (BD) in children of bipolar parents. This randomized trial examined the effects of a 4-month family-focused therapy (FFT) program on the 1-year course of mood symptoms in youth at high familial risk for BD, and explored its comparative benefits among youth in families with high vs. low expressed emotion (EE).Method-Participants were 40 youth (mean 12.3 ± 2.8 years, range 9-17) with BD not otherwise specified, major depressive disorder, or cyclothymic disorder who had a first-degree relative with BD I or II and active mood symptoms (Young Mania Rating Scale [YMRS] > 11 or Child Depression Rating Scale > 29). Participants were randomly allocated to FFT-High Risk version (FFT-HR; 12 sessions of psychoeducation and training in communication and problem-solving skills) or an education control (EC; 1-2 family sessions).Results-Youth in FFT-HR had more rapid recovery from their initial mood symptoms (hazard ratio = 2.69, p = .047), more weeks in remission, and a more favorable trajectory of YMRS scores over 1 year than youth in EC. The magnitude of treatment effect was greater among youth in high-EE (vs. low-EE) families.Conclusions-FFT-HR may hasten and help sustain recovery from mood symptoms among youth at high risk for BD. Longer follow-up will be necessary to determine if early family intervention has downstream effects that contribute to the dela...

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Section: Introductionmentioning

confidence: 99%

Early Intervention for Symptomatic Youth at Risk for Bipolar Disorder: A Randomized Trial of Family-Focused Therapy

Miklowitz

Schneck

Singh

et al. 2015

FOC

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“…Despite the relatively large number of studies describing prodromes in psychiatric disorders, for example, in bipolar disorder [20] or depression [21], there are limited data in the available literature about the percentage of children and adolescents with somatic symptoms equivalent to the symptoms indicative of a mental illness. Some light on the somatic and psychological condition of schoolchildren was thrown by a survey of health behavior conducted among 200 000 adolescents in 43 countries in Europe and North America [22].…”

Section: Discussionmentioning

confidence: 99%

Symptoms of psychiatric diseases in a pediatric neurology department

Kaczmarek¹,

Kucharska²,

Cioczek³

et al. 2017

Arch Med Sci Civil Dis

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Introduction: The present study investigated the comorbidity of psychiatric symptoms among patients with neurological diseases and the possibility of the symptoms of mental disorders being masking by the symptoms of somatic disorders. Material and methods: Eight thousand two hundred and one epicrises of all patients hospitalized at the Department of Developmental Neurology from 1st January 2003 to 31st December 2013 were analyzed in order to select a group of patients referred for consultation with a child psychiatrist. The epicrises were analyzed in terms of diagnosis and the most common psychopathological symptoms on the basis of the State-Trait Anxiety Inventory, State-Trait Anxiety Inventory for Children, Eysenck Personality Questionnaire-Revised, Beck Depression Inventory, and the Schedule for Affective Disorders and Schizophrenia for School-Aged Children – Present and Lifetime (K-SADS-PL). Results: As a result of the analysis a group of 345 patients with serious symptoms requiring psychiatric consultation was selected. In the selected group, patients had the diagnosis of neurological as well as psychiatric diseases. The most frequently mentioned were: epilepsy (13.3%), emotional disorders (11.3%), tension-type headaches (11.3%) and conversion disorders (8.4%). Dominating psychopathological symptoms were: anxiety (64%), symptoms of mood disorders (31.6%) and signs of inattention (19.7%). Suicidal ideation was manifested by 21 (6.08%) persons. Conclusions: There is a need for careful observation of the mental state of each patient of a pediatric neurology department by an interdisciplinary team of doctors, psychologists and support staff.

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“…Another article (Geller et al, 2009) also mentions zero cases of PTSD in a diagnostic list for forty-seven 14 year old PBD subjects in a neuroimaging study. A further article (Luby & Navsaria, 2010) had PTSD in a citation title but PTSD/trauma was not mentioned in the text.…”

Section: Wwwintechopencommentioning

confidence: 99%

Paediatric Bipolar Disorder – Are Attachment and Trauma Factors Considered?

Parry¹

2012

Bipolar Disorder - A Portrait of a Complex Mood Disorder

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Pediatric bipolar disorder: evidence for prodromal states and early markers

Cited by 80 publications

References 88 publications

Early Intervention for Symptomatic Youth at Risk for Bipolar Disorder: A Randomized Trial of Family-Focused Therapy

Early Intervention for Symptomatic Youth at Risk for Bipolar Disorder: A Randomized Trial of Family-Focused Therapy

Symptoms of psychiatric diseases in a pediatric neurology department

Paediatric Bipolar Disorder – Are Attachment and Trauma Factors Considered?

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