Pediatric and Teen Ovarian Tissue Removed for Cryopreservation Contains Follicles Irrespective of Age, Disease Diagnosis, Treatment History, and Specimen Processing Methods

Duncan, Francesca E.; Pavone, Mary Ellen; Gunn, Alexander; Badawy, Sherif M.; Gracia, Clarisa R.; Ginsberg, Jill P.; Lockart, Barbara; Gosiengfiao, Yasmin; Woodruff, Teresa K.

doi:10.1089/jayao.2015.0032

Cited by 27 publications

(22 citation statements)

References 60 publications

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“…13 Ovarian cortical tissue biopsies can be performed either laparoscopically or in conjunction with another open procedure such as a primary tumor resection. 14,15 Regardless of technique, an area away from the hilum that is free of visible predominant follicles and/or luteal tissue is preferred as the site of biopsy.…”

Section: Resultsmentioning

confidence: 99%

A review of reported surgical techniques in fertility preservation for prepubertal and adolescent females facing a fertility threatening diagnosis or treatment

Corkum

Laronda

Rowell

2017

The American Journal of Surgery

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Background Ovarian tissue cryopreservation is increasing as a preferred option for fertility preservation for prepubertal and young adolescent females facing a fertility threatening diagnosis or treatment. Data Sources Ovid MEDLINE and PubMed searches for terms related to ovarian tissue removal for fertility preservation revealed there is no current consensus on operative technique for surgical ovarian cortical tissue removal in adult females. Additionally, there are limited published reports of surgical approach and outcomes in the pediatric population. In total, 22 publications were reviewed for their operative approach, ovarian tissue harvesting techniques, complications and outcomes. Conclusions Reported operative approaches and techniques for ovarian tissue cryopreservation for pediatric and adolescent patients are variable. Further investigations into operative technique and tissue harvesting that maintains healthy ovarian follicles for transplant will help establish standard technical principles for surgery in pediatric and adolescent females undergoing fertility preservation.

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Section: Resultsmentioning

confidence: 99%

A review of reported surgical techniques in fertility preservation for prepubertal and adolescent females facing a fertility threatening diagnosis or treatment

Corkum

Laronda

Rowell

2017

The American Journal of Surgery

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show abstract

“…For those with ovarian tissue, options for fertility preservation include the following: (1) embryo banking, which requires hormonal stimulation for retrieval and a suitable sperm donor, (2) oocyte banking, also requiring hormonal stimulation for retrieval, and (3) ovarian tissue cryopreservation, which requires retransplantation in the future, or in vitro maturation techniques, which are currently experimental. 5 While still experimental, there have been at least 60 live births following tissue transplant and either in vitro fertilization with induction of oocyte maturation or natural pregnancies. 6 For those with testicular tissue, sperm is obtained for cryopreservation through masturbation or testicular sperm extraction.…”

Section: Fertility Preservation Options For Postpubertal Youthmentioning

confidence: 99%

Proceedings of the Working Group Session on Fertility Preservation for Individuals with Gender and Sex Diversity

et al. 2016

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Children and adolescents with gender and sex diversity include (1) gender-nonconforming and transgender individuals for whom gender identity or expression are incongruent with birth-assigned sex (heretofore, transgender) and (2) individuals who have differences in sex development (DSD). Although these are largely disparate groups, there is overlap in the medical expertise necessary to care for individuals with both gender and sex diversity. In addition, both groups face potential infertility or sterility as a result of desired medical and surgical therapies. The Ann & Robert H. Lurie Children’s Hospital of Chicago (Lurie Children’s) gender and sex development program (GSDP) provides specialized multidisciplinary care for both transgender and DSD patients. In response to patient concerns that recommended medical treatments have the potential to affect fertility, the Lurie Children’s GSDP team partnered with experts from the Oncofertility Consortium at Northwestern University to expand fertility preservation options to gender and sex diverse youth. This article summarizes the results of a meeting of experts across this field at the annual Oncofertility Consortium conference with thoughts on next steps toward a unified protocol for this patient group.

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“…In the United States, the National Physicians Cooperative (NPC), which is part of the Oncofertility Consortium, is a nationwide infrastructure of clinical and allied sites committed to providing personalized fertility preservation care (Gracia and Woodruff 2012, Gracia, et al 2012) (http://www.oncofertility.northwestern.edu/health-professionals/npc-membership-info-and-npc-resources). Several NPC sites offer OTC under institutional review board (IRB)-approved protocols, and the number of OTC cases reported through the NPC has increased steadily in the past decade (Duncan, et al 2015). Interestingly, and perhaps not surprisingly, the largest increase in the use of OTC in the NPC has occurred in the pediatric and young adult population, potentially because of increased awareness about this option and the expanding list of medical conditions and treatments that can compromise fertility (Duncan, et al 2015, Hirshfeld-Cytron, et al 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Several NPC sites offer OTC under institutional review board (IRB)-approved protocols, and the number of OTC cases reported through the NPC has increased steadily in the past decade (Duncan, et al 2015). Interestingly, and perhaps not surprisingly, the largest increase in the use of OTC in the NPC has occurred in the pediatric and young adult population, potentially because of increased awareness about this option and the expanding list of medical conditions and treatments that can compromise fertility (Duncan, et al 2015, Hirshfeld-Cytron, et al 2011). …”

Section: Introductionmentioning

confidence: 99%

Ovarian tissue transport to expand access to fertility preservation: from animals to clinical practice

et al. 2016

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Primordial follicles dictate a female’s reproductive lifespan and therefore are central to fertility preservation for both endangered species as well as for individuals with fertility threatening conditions. Ovarian tissue containing primordial follicles can be cryopreserved and later thawed and transplanted back into individuals to restore both endocrine function and fertility. Importantly, increasing numbers of human live births have been reported following ovarian tissue cryopreservation and transplantation. A current limitation of this technology is patient access to sites that are approved or equipped to process and cryopreserve ovarian tissue – especially in larger countries or low resource settings. Here we review empirical evidence from both animal models and human studies that suggest that ovarian tissue can be transported at cold temperatures for several hours while still maintaining the integrity and reproductive potential of the primordial follicles within the tissue. In fact, several human live births have been reported in European countries using tissue that was transported at cold temperatures for up to 20 hours prior to cryopreservation and transplantation. Ovarian tissue transport, if implemented widely in clinical practice, could therefore expand both patient and provider access to emerging fertility preservation options.

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Pediatric and Teen Ovarian Tissue Removed for Cryopreservation Contains Follicles Irrespective of Age, Disease Diagnosis, Treatment History, and Specimen Processing Methods

Cited by 27 publications

References 60 publications

A review of reported surgical techniques in fertility preservation for prepubertal and adolescent females facing a fertility threatening diagnosis or treatment

A review of reported surgical techniques in fertility preservation for prepubertal and adolescent females facing a fertility threatening diagnosis or treatment

Proceedings of the Working Group Session on Fertility Preservation for Individuals with Gender and Sex Diversity

Ovarian tissue transport to expand access to fertility preservation: from animals to clinical practice

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