Peculiarities of the Technology, Quality Control, and Pharmaceutical Development of Extemporaneous Preparations for Children

Yarnykh, Т. G.; Rukhmakova, O. A.

doi:10.1007/s11094-015-1234-8

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“…Thus, analyzing the technological process of preparation of infusions and decoctions, we observe that the ratio of MPRM and extractant and modes and duration of infusion differ [23][24][25][26].…”

Section: Discussionmentioning

confidence: 99%

“…Normative documentation used in Ukraine and regulating the extemporaneous technology of infusions and decoctions is currently represented only by the guideline «Requirements for the manufacture of non-sterile drugs in pharmacies» (approved by the order of the Ministry of Health of Ukraine from July 1, 2015 No. 398) [23]. The main approaches to the technology of infusions and decoctions in pharmacies are given in Table 3.…”

Section: Discussionmentioning

confidence: 99%

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Pharmacopeial aspects of preparation of infusions and decoctions in pharmacies

2021

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An analytical review of pharmacopoeial aspects of preparation of infusions and decoctions in pharmacies is presented. The aim of this work is to conduct a comparative analysis of pharmacopoeial requirements for the technology of infusions and decoctions in pharmacies. Materials and methods of the research. Comparative analysis of pharmacopoeial requirements was performed using methods of systematic and structural-logical analysis. Results and discussions. It was found that in many pharmacopoeias (European, British, Italian, French, Czech, Kazakh) there are no instructions on the pharmacy technology of these dosage forms. Only the pharmacopoeias of Japan, Austria, Belarus and Russia contain separate monographs on the extemporaneous preparation of infusions and decoctions. After analyzing these monographs, it was found that the definition of infusions and decoctions as a dosage form differs. It was found that the Japanese Pharmacopoeia regulates the preliminary preparation of medicinal plant raw materials (soaking for 5 minutes in water), in other pharmacopoeias there is no such requirement. When conducting a comparative analysis of the technology of preparation of infusions and decoctions, we observe that the ratio of medicinal plant raw materials (MPRM) and extractant and extraction modes differ. Conclusions. An analytical review of pharmacopoeial aspects of preparation of infusions and decoctions in pharmacies is presented. A comparative analysis of the requirements for technology and quality control of infusions and decoctions in accordance with pharmacopoeial articles revealed both different and similar information. The results of the research showed that despite the differences in the structures of articles and names, as well as approaches to the definition of this dosage form, some requirements are similar (particle size of MPRM). The differences that were found include the ratio of MPRM and extractant, extraction modes. Taking into account the data of the analysis and the existing national requirements, the authors proposed a draft general pharmacopoeial article “Infusions and decoctions made in pharmacies”.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%