Peculiarities of the Brain Functional State in Hiv Patients

Громова, Е А; Bogdan, A. A.; Катаева, Г. В.; Kotomin, I. A.; Хоменко, Ю. Г.; Korotkov, Alexander; Трофимова, Т. Н.; Рассохин, В. В.; Беляков, Н. А.

doi:10.22328/2079-5343-2016-1-41-48

Cited by 7 publications

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“…Â íàøåé ïðåäûäóùåé ðàáîòå òàêaeå áûëî âûÿâëåíî, ÷òî â ãðóïïå áîëüíûõ ÁÏ ñ íà÷àëüíûìè ïðîÿâëåíèÿìè êîãíèòèâíûõ íàðóøåíèé ñíèaeåí óðîâåíü ÑÌÃ â òåìåííîé êîðå â ÏÁ 7 è 39 [29], â êîòîðûõ â íàñòîÿùåì èññëåäîâàíèè ïîëîaeèòåëüíî êîððåëèðîâàëî ñ ñîäåðaeàíèåì NAA è îòðèöàòåëüíî -ñ Cho. Ðàíåå áûëè âûÿâëåíû êîððåëÿöèè NAA/Cr è NAA/Cho â áåëîì âåùåñòâå ñóïðàâåíòðèêóëÿðíûõ ïðîñòðàíñòâ ñ ÑÌÃ â ïîÿñíîé èçâèëèíå ó ÂÈ×-èíôèöèðîâàííûõ ïàöèåíòîâ è ïðè äåìåíöèè, ÷òî ìîaeåò ãîâîðèòü î ñóùåñòâîâàíèè îáùåãî ýëåìåíòà ïàòîãåíåçà êîãíèòèâíûõ íàðóøåíèé, ñâÿçàííîãî ñ ôóíêöèîíèðîâàíèåì ëèìáè-÷åñêîé ñèñòåìû [30].…”

Section: Discussionunclassified

Magnetic resonance spectroscopy in Parkinson’s disease

et al. 2020

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Introduction. Modern neuroimaging methods allow to evaluate in vivo biochemical processes in the brain. Such methods include magnetic resonance spectroscopy (MRS) and positron emission tomography (PET). While PET is the “golden standard” in assessing the brain functional state and is widely used in neurodegenerative diseases, the diagnostic value of MRS remains undefined due to the inconsistency of the results obtained in different studies. At the same time, MRC allows obtaining information on the content of many metabolites in living tissues, including N-acetyl aspartate (NAA), which is considered to be a surrogate marker of neuronal integrity, choline (Cho), associated with membrane metabolism, Cr - energy metabolism, etc. The aim of this study is to compare MRS and PET data in patients with Parkinson’s disease (PD).Materials and methods. Twenty-six patients with PD stages I to III according to the Hoehn and Yahr Scale and age-matching control group of neurologically and cognitively intact people were examined. All patients underwent neurological examination, a multivoxel MRS of the supraventricular region, including white and gray matter, and PET with 18F-fluorodeoxyglucose (FDG) to assess cerebral metabolic rate of glucose (CMRglu).Results. Decrease of NAA/Cr and NAA/Cho in the white matter in the left hemisphere was revealed in PD group compared to control, with the NAA/Cr ratio negatively correlating with the stage of the disease of the Hoehn and Yahr Scale. The NAA content in the white matter and the cingulate cortex positively correlated with CMRglu in Brodmann fields 5–7, 8–10, 22, 23, 46. At the same time, Cho/Cr ratio negatively correlated with CMRglu in the cortical areas associated with the development of cognitive impairment in PD (Brodman areas 9, 10, 39, 47).

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Section: Discussionunclassified

Magnetic resonance spectroscopy in Parkinson’s disease

et al. 2020

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“…Поражение нервной системы может наблюдаться на любой стадии ВИЧ-инфекции, клинические проявления крайне разнообразны -от минимальных до крайне тяжелых, приводящих к ранней инвалидизации и смерти пациентов. У 4-45 % пациентов появление неврологической симптоматики является манифестацией заболевания [2,3]…”

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X-Ray Diagnostics of Brain Damage in Unidentified Hiv Infection

Sudarkina¹,

Дергилев²,

Kuzovkova³

et al. 2021

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Brain damage can be observed at any stage of HIV infection, and the spectrum of its causes is extremely diverse. Neuroimaging techniques play a key role in assessing brain lesions. The article describes a clinical case of multifocal brain damage in a patient with undiagnosed HIV infection, discusses the possibilities of various methods of radiation examination for differential diagnosis, demonstrates the most important role of a comprehensive clinical examination for making a diagnosis.

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