Peculiarities of Morphoetiopathogenesis of Acute Appendicitis and Consequences After Appendectomy

Гринь, Володимир Григорович; Drabovskiy, Vitaliy S; Sytnik, Dmytro A; Ryabuschko, Roman M; Riabuschko, Mykola M; Білаш, С. М.; Gonzhak, Bohdan I

doi:10.36740/wlek202206112

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…However, the data presented in our publication on the consolidation of the greater omentum and serous formations of the epididymides, completely homologous to the latter (Hryn et al, 2022;Hryn et al, 2023b), with the perforated openings of the cecum have not been found in the scientific literature, as well as the morphological aspects of the local immune response to infection of the peritoneal cavity of the experimental animals.…”

Section: Discussionmentioning

confidence: 67%

“…Currently, in experimental medicine, many different methods of modeling septic peritonitis are known (Sydorchuk, 2015;Vintrych et al, 2022;Brown et al, 2023). At the same time, in each case, the experiment should consider the optimal assessment of known etiological factors in its pathogenesis, among which the most common cases are ulcerative perforation of the stomach or duodenum, as well as perforation of the cecal appendage in its gangrenous inflammation (Hryn et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

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Morphological Characteristics of the Results of Experimental Modeling of Septic Peritonitis

Hryn,

Maksymenko

2024

Int. J. Morphol.

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Experimental studies devoted to the study of the mechanisms of the pathogenesis of acute peritonitis and the development of new methods of medical and surgical treatment are becoming increasingly relevant. Today, experimental medicine knows many different ways to modeling septic peritonitis and eliminate it, but the role of the local immune system is underestimated, whereas it takes a direct part in inflammation. The objective of our work to study morphological features of results of experimental modeling of septic peritonitis in white rats. The study included 15 sexually mature white male rats weighing 276.75±6.56 grams. A simulation of septic peritonitis was performed by perforating the upper part of the cecum with four punctures with a G16 injection needle. As a result of the experiment, after examination of the peritoneal cavity, all 15 animals were diagnosed with omentum tamponade of perforated damage to the caecum. In 11 cases, the perforated wall of the caecum was covered by the greater omentum (73.34 %), and in the other 4 animals, tamponade was performed by one of the epididymal omentum (26.66 %). The initial stage of tamponade with the greater or epididymal omentums of a perforated caecum begins on the first day of the experiment and consists of tight interstitial consolidation between them, as well as in the invasion of blood vessels from the omentum side to the focus of infection, which ensure the delivery of the appropriate immunocompetent cells. As a result of this process, intensive lymphoid infiltrates are formed in this area, as well as the growth of adipose tissue, which isolates the inflammatory focus from the peritoneal cavity with a thick layer.

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Section: Discussionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Morphological Characteristics of the Results of Experimental Modeling of Septic Peritonitis

Hryn,

Maksymenko

2024

Int. J. Morphol.

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“…Тому Yildirim A. (2010) і Hryn V. (2022) вважають подібні лімфоїдні скупчення імунними фабриками черевної порожнини [9,13]. Незважаючи на те, що ще в 1921 році вчені наголошували на наявності молочних плям у в черевній порожнині та їх велике біологічне значення, результатів експериментальних досліджень, пов'язаних з молочними плямами все ще залишається відносно мало.…”

Section: вступunclassified

Distribution and Characteristics of Mesenteric Milk Spots in Healthy Rats and Those With Adhesion Disease

Paydarkina,

Kush

2024

Act. Probl. of the Modern Med.

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Introduction. The adhesion process occurs in more than 80% of cases after all abdominal operations. The process of adhesion formation and, as a consequence, chronic inflammation involve the lymphoid elements (Peyer's spots, solitary follicles) present in the peritoneum and submucosa of the intestine, causing a pathological immune response. Fat-associated lymphoid clusters (FALCs), known as mammary structures, are also found in other fat reservoirs, such as the pericardium, mediastinum, and pleural cavity. The problem of visualizing milk spots in various structures of the peritoneum remains open. Relevance. Despite the fact that as early as 1921, scientists emphasized the presence of milk spots in the abdominal cavity and their great biological significance, the results of experimental studies related to milk spots are still relatively few. The novelty consists in investigating the peculiarities of the distribution of milk spots in the mesentery of the intestine with adhesion disease in rats in comparison with the health animals. Objective of this study is to detect milk spots, to investigate their topography and structure in the mesentery of the intestine in the health and in adhesion disease. Materials and methods: The experiment involved tissue preparation, macroscopic examination, histological analysis of hematoxylin and eosin-stained film preparations. Results. Milk spots of the intestinal mesentery in rats from the intact group are represented by round formations, 1-2 μm in diameter, white in color, uniformly and diffusely located on the area of the mesentery of the small and large intestine. Microscopically, they are characterized as a cluster of lymphocytes, plasma cells, and macrophages belonging to FALC lymphoid tissue. The area of milk spots of the peritoneum in the experimental groups varies depending on the course of the process of adhesion formation. Individual small white and gray granulations were observed in the animals of the II experimental group on the 7th day. On the 14th day of observation in the III group, the diameter of the milk spots reached 2-2.5 mm, they appeared as white granular clusters. On the 21st day, the animals of the IV group demonstrated an abundant accumulation of elliptical whitish structures, 3-4 mm in diameter near the blood vessels that differed significantly from the indicators of the other groups. Conclusion. The study has expanded knowledge regarding the distribution and composition of milk spots in the normal mesentery compared to those observed in adhesion disease. According to data obtained, milk spots are lymphoid tissue, represented by various types of lymphocytes, macrophages and plasma cells. The question of whether the lymphocytes found in the milk spots belong to different subpopulations, the dynamics of their number during the main stages of adhesion formation, remains an open question requiring further scientific research.

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“…Проблема перитоніту на сьогодні вивчена досить широко [11,[33][34][35]. Перитоніт є ускладненням, а точніше -неминучим наслідком або етапом розвитку різних гострих хірургічних захворювань і травм органів черевної порожнини.…”

Section: роль великого чепця при перитонітіunclassified

The Greater Omentum of White Rats: Structural and Functional Characteristics and its Role in Peritonitis

Maksymenko¹,

Гринь²

2023

Ukr. ž. med. bìol. sportu

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The greater omentum is now recognized as an important organ in the fight against intra-abdominal infections, so it is often called the “policeman of the peritoneal cavity”. The greater omentum plays the most important role in the implementation of immune supervision of the antigenic condition of the peritoneal fluid and rapid response of damage to the gastrointestinal tract, which is often complicated by inflammation of the peritoneum – peritonitis. The purpose of the work was to study the peculiarities of the structure of the greater omentum of white rats and its role in peritonitis by means of a bibliographic analysis of the literature. Materials and methods. This bibliographic analysis is based on published articles, books, textbooks, monographs and dissertation abstracts. For the purposes of this systematic review, a literature search was carried out in the worldwide Internet, domestic sources of literature, scientific and electronic library of Poltava State Medical University using the following key words: “morphology”, “comparative anatomy”, “greater omentum”, “greater omentum of the rats”, “immune system”, “white rats”, “laboratory animals”, “rat anatomy”, “peritonitis”. Results and discussion. The greater omentum of white rats and humans are represented by two different structures: translucent membranous regions and regions rich in adipose tissue. According to the literature, the greater omentum of white rats is the main morphological characteristic (in miniature), homologous to the human one. The main function of the greater omentum, according to the opinion of many authors and ours too, is immunity. Immune structures of the greater omentum of white rats are represented by lymphoid nodules, known in the literature as milky spots, most of which are located near arteries and veins. In pathological conditions, the greater omentum acquires absolutely special properties, such as plasticity, the ability to fuse with a traumatic and inflamed surface, the ability to hemostasis and phagocytosis, the ability to germinate and revascularize, to absorb fluids and microparticles from the peritoneal cavity, and the ability to the immunological response. Conclusion. According to the literature, the greater omentum of white rats is a miniature likeness of the greater omentum of a person. However, unlike the latter, it consists of only one duplication of the visceral peritoneum, between the leaves of which there are blood vessels with deposits of adipose tissue and milk spots. Thus, the greater omentum of white rats is a perfectly acceptable object of experimental research with the subsequent legitimate extrapolation of their results to humans. The greater omentum occupies a central place in the peritoneal defense mechanisms due to its innate immune function, high absorbing capacity, and ability to attach to neighboring structures to close defects of abdominal organs and promote their healing, due to its expressive angiogenic activity

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Peculiarities of Morphoetiopathogenesis of Acute Appendicitis and Consequences After Appendectomy

Cited by 6 publications

References 13 publications

Morphological Characteristics of the Results of Experimental Modeling of Septic Peritonitis

Morphological Characteristics of the Results of Experimental Modeling of Septic Peritonitis

Distribution and Characteristics of Mesenteric Milk Spots in Healthy Rats and Those With Adhesion Disease

The Greater Omentum of White Rats: Structural and Functional Characteristics and its Role in Peritonitis

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