Peculiarities of formation and clinical course of symptomatic epilepsy as a result of cranial injury

Kaptalan, A. O.; Stoyanov, A. N.; O., Ostapenko, I.; Kirchev, V. V.; Yermuraki, P. P.

doi:10.12775/jehs.2021.11.01.014

Cited by 5 publications

(5 citation statements)

References 2 publications

(1 reference statement)

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“…The analysis of the obtained data indicates a correlation in the majority of cases between the anti-ischemic effects provided by intranasal Semax administration and the combined SEM and HA administration. Our data in this context coincide with the results that demonstrated the effectiveness of intranasal administration of pharmacological compounds in ischemic and traumatic brain injuries [1,4,5,14,25,26]. With this in mind, we consider the obtained data as additional experimental rationale for the feasibility of clinically testing the effects of pharmacological compounds capable of restoring learning and memory processes in patients with CBI.…”

Section: Discussionsupporting

confidence: 86%

Cognitive function restoration in rats with chronic brain ischemia using Semax and hopantenic acid comprehensive administration

Kirchev

2023

J Educ Health Sport

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The relevance and importance of treating patients with ischemic brain lesions are indisputable. Chronic ischemic processes in the brain occur much more frequently than acute cerebral circulation disorders, leading to prolonged disability and being the main contributors to a significant number of strokes. Cognitive dysfunctions prevail in the dynamics of the post-ischemic period and are often the primary determinants of the severity of residual organic and subsequent functional impairments of the brain. The aim of the study is to investigate the effectiveness of separate and combined administration of Semax and hopantenic acid in the pharmacological correction of cognitive disorders in rats with experimental chronic brain ischemia. It has been established that rats with chronic brain ischemia exhibit cognitive impairments from the 1st day, manifested in worsened learning processes, short-term and long-term memory functioning in the context of conditioned active avoidance and conditioned feeding reflexes. It has been shown that separate and combined application of Semax and hopantenic acid contributes to the restoration of the learning process and improvement of mnestic functions in rats with chronic brain ischemia. The most pronounced nootropic effect in rats with chronic brain ischemia was registered under the conditions of combined administration of Semax and hopantenic acid, starting from the 3rd day of the study. Subsequently, in terms of anti-ischemic efficacy, the effect of Semax follows, which was realized starting from the 3rd day of the study. The least pronounced neuroprotective effect belongs to hopantenic acid, starting from the 7th day of the study. The author considers the obtained data as experimental groundwork for the feasibility of clinically testing the nootropic effects of the combined administration of Semax and hopantenic acid in cases of chronic brain ischemia. The comprehensive pharmacological correction of cognitive disorders in chronic brain ischemia is pathogenetically justified and aimed at activating sanogenetic mechanisms.

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Section: Discussionsupporting

confidence: 86%

Cognitive function restoration in rats with chronic brain ischemia using Semax and hopantenic acid comprehensive administration

Kirchev

2023

J Educ Health Sport

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“…Though akin treatment modalities have been previously employed for cerebrovascular pathology [2,5,6,14], our aim was to substantially augment the effectiveness of experimental correction for motor disturbances ensuing from CBI via intranasal drug administration.…”

Section: Discussionmentioning

confidence: 99%

“…These investigations involved determining temporal intervals and potential synergies among specific pharmacological agents. Pharmacological compounds were chosen as agents for secondary neuroprotection, targeting pathogenetic pathways initiated by ischemic neuronal damage [2,4,5,15,21].…”

Section: Abstract: Cerebrovascular Pathology; Chronic Brain Ischemia;...mentioning

confidence: 99%

Muscle activity and emotional behavior changes in rats with chronic brain ischemia via comprehensive pathogenetic correction

Kirchev

2023

J Educ Health Sport

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Cerebrovascular pathology has evolved from a medical concern to a social issue, with the efficacy of secondary neuroprotection remaining a pertinent question. While some investigations have been conducted to elucidate the effectiveness of a comprehensively grounded pharmacological correction scheme under conditions of experimentaly induced chronic brain ischemia, further refinement is necessary to understand the behavioral effects of animals, dosages, routes of administration of pharmacological agents, and analysis of obtained data. The aim of this study was to assess the effectiveness of applying Semax and hopantenic acid in the comprehensive treatment of motor disorders and established neurological impairments in rats with experimentally induced chronic brain ischemia. We determined that rats with chronic brain ischemia exhibit muscular dysfunctions and experience pronounced disturbances in emotional behavior from the first day. It has been demonstrated that the separate and combined application of Semax and hopantenic acid contributes to the restoration of muscle activity, normalization of coordination, and emotional behavior in rats with chronic brain ischemia. The most significant neuroprotective effect in rats with chronic brain ischemia was observed with the combined administration of Semax and hopantenic acid, starting from the 3rd day of the trial. The subsequent in the series of anti-ischemic effectiveness is the impact of Semax from the 3rd day of the experiment. The least pronounced neuroprotective effect was exhibited by hopantenic acid, starting from the 5th day of the experiment. We consider these findings to be an experimental foundation supporting the feasibility of clinically testing the effects of combined Semax and hopantenic acid administration, capable of restoring functional disorders caused by chronic brain ischemia. In conclusion, the observed effectiveness of the developed pathogenetically justified complex for the correction of post-ischemic muscle dysfunction and disorders indicates the development of an anti-ischemic effect, as well as the fundamental possibility of improving the treatment for patients with chronic brain ischemia through clinical intranasal administration of Semax, either alone or in combination with hopantenic acid. However, for a more comprehensive understanding of the temporal and dose-dependent effects of this complex pathogenetic correction scheme on other disorders and dysfunctions related to chronic brain ischemia and to formulate final conclusions, it is essential to conduct separate series of experimental studies.

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“…Considering the substantial TBI burden on society, including possible postraumatic epilepsy onset and other Shemet Ya.A., Ziablitsev S.V., Likhodiievskyi V.V., Korsak A.V., Sychov O.O., Chukhrai S.M. comorbidities [5,6] the search for new treatment methods, including drug design with the identification of new molecules, is highly relevant.…”

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confidence: 99%

The Effect of Gaba-Benzodiazepine Receptor Complex Modulators (Mptd-01 and Bs 34-20) on the Cerebral Cortex After Experimental Brain Injury

Shemet,

Ziablitsev,

Likhodiievskyi

et al. 2024

Med. Sci. of Ukr.

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Background. Traumatic brain injury (TBI) is a major medical, social, and public health problem, In the military population the TBI incidence also remains high due to blunt head trauma and blast injuries. Considering the substantial TBI burden on society, including possible postraumatic epilepsy onset and other comorbidities the search for new treatment methods, including drug design with the identification of new molecules, is highly relevant. Aim: The study aimed to evaluate the effect of GABA-benzodiazepine receptor complex modulators (hydrogenated 2,3-benzodiazepines MPTD-01 та BS 34-20) on rat cerebral cortex after traumatic brain injury Materials and methods. The experiment was carried out on male Wistar rats. To obtain traumatic brain injury we used the weight drop model. Based on the received treatment, the Rats were divided into intact, placebo (II), and MPTD-01 (III) and BS 34-20 (IV) groups. The cerebral cortex in the impact zone was harvested for examination. The light microscopy was performed on 3, 7, 14, and 21 days after injury. Results. The observed histological picture of the changes in the cerebral cortex, especially in the II group is similar to those, described by other research papers as mild- to severe traumatic brain injury. The reproduction of the blunt trauma model leads to a series of typical changes that replace each other and can be characterized as alteration, edema, phase of cellular reactions, and repair. Unlike the placebo group, the III and IV experimental groups (GABA-benzodiazepine receptor complex modulators administration) cerebral cortex demonstrated a smoothing of the swelling phase and its reduction, a shift in the time phase of cellular reactions to a later time. In the BS 34-20 group, minimal edema was observed on the 21st day of the experiment. Conclusion. Such morphological changes can be considered a neuroprotective effect, however, to fully characterize the effects of the GABA-benzodiazepine receptor complex modulators, glial reactions and neuron-glial interactions should be investigated.

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Peculiarities of formation and clinical course of symptomatic epilepsy as a result of cranial injury

Cited by 5 publications

References 2 publications

Cognitive function restoration in rats with chronic brain ischemia using Semax and hopantenic acid comprehensive administration

Cognitive function restoration in rats with chronic brain ischemia using Semax and hopantenic acid comprehensive administration

Muscle activity and emotional behavior changes in rats with chronic brain ischemia via comprehensive pathogenetic correction

The Effect of Gaba-Benzodiazepine Receptor Complex Modulators (Mptd-01 and Bs 34-20) on the Cerebral Cortex After Experimental Brain Injury

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