Peculiarities of Diagnostics and Course of Uterine Cervical Cancer Among Hiv-Infected Women

Abstract

Objective: To assess the clinical course of uterine cervical cancer (UCC) against the background of HIV infection and its complex diagnosis. Methods: A retrospective analysis carried out to 847 outpatient cards of patients for the period 2016-2017. Of these, 17 were HIV-positive. Two groups were formed: group I – patients with UCC on the background of HIV, group II – patients with UCC without HIV. The mean age was 37.4±0.2 and 52.8±0.3 years, respectively. Stages of UCC in group I: IIB – 6 (35.5%), IIIA – 4 (23.5%), IIIB – 6 (35.5%), IVB – 1 (5.5%); in the II group: IB – 3 (15%), IIB – 10 (50%), IIIB – 6 (30%), IVB – 1 (5%). Distribution according to the histological structure in group I: squamous nonkeratinized cancer – 11 (68.75%), keratinizing – 1 (6.25%), adenocarcinoma – 4 (25%). In group II: squamous nonkeratinized cancer – 13 (65%), squamous keratinizing – 3 (15%), adenocarcinoma – 4 (2%). The groups were comparable in treatment methods: in both groups, chemoradiation therapy was used according to standard schemes. Results: Indicators in the I group: lethality – 4 (23.5%), stabilization – 5 (23.5%), progression – 8 (53%); in the second group: lethality – 1 (5%), stabilization – 14 (70%), progression – 5 (25%). Conclusion: UCC in the background of HIV infection occurs at an earlier age. The predominance of stage IIB disease and squamous nonkeratinized cancer in both groups was noted. Mortality within the first year, stabilization and progression in the I and II groups were 23.5%, 23.5%, 53% and 5%, 70%, 25%, respectively. Keywords: Human immunodeficiency virus (HIV), uterine cervical cancer, lethality, stabilization, progressing.