Peculiarities of Brain Information Processing in Persons with Different Serotonin Transporter Gene Variants

Sysoeva, Olga; Smirnov, Kirill; Shleptsova, V. A.; Ivanitsky, Alexey; Tonevitsky, Alexander G.

doi:10.1007/s10517-010-0803-9

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…For example, carriers of more active gene variants are reported to have increased brain potential in mismatch negativity and decreased potential in P300 [42,64]. The extant literature regarding serotonin level, EEG neuromatrix, and behavioral phenotypes, nevertheless, seems to not converge well, with some reports remaining hard to reconcile.…”

Section: Discussionmentioning

confidence: 99%

“…The detrimental effects on neural architecture at both the local and inter-regional levels might explain why the S-allele of 5-HTTLPR manifests as a general vulnerable factor in so many psychiatric conditions [2-12,63]. 5-HTT polymorphism is reported to deviate electrocortical activity relevant to attention and automatic perceptual detection [41,42]. Since gamma activity has been suggested as correlates of attention and sensory binding [78-81], the significant differences in gamma frequency bands for 5-HTTVNTR polymorphism warrant further study to replicate and extend.…”

Section: Discussionmentioning

confidence: 99%

“…The risk allele of 5-HTTLPR is related to mildly increased right frontal asymmetry and imposes no direct effect on target N1 and novelty N1 potentials [40,41]. The more active variant of serotonin transporter is associated with enhanced mismatch negativity and decreased P300 components [42]. Whether the differential expression of the serotonin transporter alters neural characteristics in the resting state remains unexplored.…”

Section: Introductionmentioning

confidence: 99%

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The influence of serotonin transporter polymorphisms on cortical activity: A resting EEG study

Lee

Yu²,

Tsai

et al. 2011

BMC Neurosci

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BackgroundThe serotonin transporter gene (5-HTT) is a key regulator of serotonergic neurotransmission and has been linked to various psychiatric disorders. Among the genetic variants, polymorphisms in the 5-HTT gene-linked polymorphic region (5-HTTLPR) and variable-number-of-tandem-repeat in the second intron (5-HTTVNTR) have functional consequences. However, their genetic impact on cortical oscillation remains unclear. This study examined the modulatory effects of 5-HTTLPR (L-allele carriers vs. non-carriers) and 5-HTTVNTR (10-repeat allele carriers vs. non-carriers) polymorphism on regional neural activity in a young female population.MethodsBlood samples and resting state eyes-closed electroencephalography (EEG) signals were collected from 195 healthy women and stratified into 2 sets of comparisons of 2 groups each: L-allele carriers (N = 91) vs. non-carriers for 5-HTTLPR and 10-repeat allele carriers (N = 25) vs. non-carriers for 5-HTTVNTR. The mean power of 18 electrodes across theta, alpha, beta, gamma, gamma1, and gamma2 frequencies was analyzed. Between-group statistics were performed by an independent t-test, and global trends of regional power were quantified by non-parametric analyses.ResultsAmong 5-HTTVNTR genotypes, 10-repeat allele carriers showed significantly low regional power at gamma frequencies across the brain. We noticed a consistent global trend that carriers with low transcription efficiency of 5-HTT possessed low regional powers, regardless of frequency bands. The non-parametric analyses confirmed this observation, with P values of 3.071 × 10-8 and 1.459 × 10-12 for 5-HTTLPR and 5-HTTVNTR, respectively.Conclusions and LimitationsOur analyses showed that genotypes with low 5-HTT activity are associated with less local neural synchronization during relaxation. The implication with respect to genetic vulnerability of 5-HTT across a broad range of psychiatric disorders is discussed. Given the low frequency of 10-repeat allele of 5-HTTVNTR in our research sample, the possibility of false positive findings should also be considered.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The influence of serotonin transporter polymorphisms on cortical activity: A resting EEG study

Lee

Yu²,

Tsai

et al. 2011

BMC Neurosci

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“…The state of public opinion in a society can influence people's decision-making process in the event of an emergency. Public opinion is an attitude or a behavioral response exhibited by an objective thing, which plays a role of bridge in the process of balance and imbalance (Sysoeva et al, 2009;Balestrini, 2015). Hence, when a person is in a positive public opinion atmosphere, it means that that current environment balances his demands (Chen et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Cognitive Decision-making and Public Opinions

Wang¹

2018

Neuroquantology

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The influence of public opinions on emergency decision-making has attracted more and more attention in recent years. Emergency decision-making is characterized by high risk, fuzzy information and time pressure. Public opinions induced by emergency have important influence on people's decision-making preference. Based on the four induced conditions, including positive public opinion, neutral public opinion, negative public opinion and public opinion induced by emergent situations, this paper studies the brain evoked potential information of subjects and proposes a new intuitive decision-making model. The results show that the average scores of the positive opinion group on the positive scale are significantly different, while the scores of the negative opinion group on the negative scale are significantly different. Participants in group of public opinion induced by emergent situations tend to be more adventurous in their decision-making preferences than those in the negative public opinion group. The results of brain information processing of neutral, positive and negative public opinion groups show that both the standard stimulus and deviant stimulus could induce obvious negative deflection in 100-200ms in EEG. In the processing the information induced by emergent situations, amplitude deviation between the standard stimulus and deviant stimulus is smaller, which is perceived as insensitive.

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The mismatch negativity (MMN) – A unique window to disturbed central auditory processing in ageing and different clinical conditions

Näätänen

Kujala

Escera

et al. 2012

Clinical Neurophysiology

341

252

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Peculiarities of Brain Information Processing in Persons with Different Serotonin Transporter Gene Variants

Cited by 3 publications

References 12 publications

The influence of serotonin transporter polymorphisms on cortical activity: A resting EEG study

The influence of serotonin transporter polymorphisms on cortical activity: A resting EEG study

Cognitive Decision-making and Public Opinions

The mismatch negativity (MMN) – A unique window to disturbed central auditory processing in ageing and different clinical conditions

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