The mismatch negativity (MMN) – A unique window to disturbed central auditory processing in ageing and different clinical conditions

Näätänen, Risto; Kujala, Teija; Escera, Carles; Baldeweg, Torsten; Kreegipuu, Kairi; Carlson, Synnöve; Ponton, Curtis W.

doi:10.1016/j.clinph.2011.09.020

Cited by 340 publications

(276 citation statements)

References 754 publications

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“…Furthermore, there is an attentionrelated ERP, the N2-posterior-contralateral (N2pc), which is typically observed in the N2 time window at posterior scalp sites that are contralateral to the position of a potential target item on which attention is focused (Patel and Azzam 2005). The N2a that is elicited by deviant auditory stimuli, attended or unattended, is referred to as mismatch negativity (MMN; for a review, see Naatanen et al 2012). P3 is an umbrella term that encompasses at least two functionally distinct subcomponents with different scalp distributions, P3a and P3b (Polich 2007;O'Connell et al 2012).…”

Section: Erps For Inhibition Between 200 and 400 Msmentioning

confidence: 99%

Event-Related Brain Potentials in the Study of Inhibition: Cognitive Control, Source Localization and Age-Related Modulations

et al. 2014

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In the previous fifteen years, a variety of experimental paradigms and methods have been employed to study inhibition. In the current review, we analyze studies that have used the high temporal resolution of the event-related potential (ERP) technique to identify the temporal course of inhibition to understand the various processes that contribute to inhibition. ERP studies with a focus on normal aging are specifically analyzed because they contribute to a deeper understanding of inhibition. Three time windows are proposed to organize the ERP data collected using inhibition paradigms: the 200 ms period following stimulus onset; the period between 200 and 400 ms after stimulus onset; and the period between 400 and 800 ms after stimulus onset. In the first 200 ms, ERP inhibition research has primarily focused on N1 and P1 as the ERP components associated with inhibition. The inhibitory processing in the second time window has been associated with the N2 and P3 ERP components. Finally, in the third time window, inhibition has primarily been associated with the N400 and N450 ERP components. Source localization studies are analyzed to examine 2 the association between the inhibition processes that are indexed by the ERP components and their functional brain areas. Inhibition can be organized in a complex functional structure that is not constrained to a specific time point but, rather, extends its activity through different time windows. This review characterizes inhibition as a set of processes rather than a unitary process.

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Section: Erps For Inhibition Between 200 and 400 Msmentioning

confidence: 99%

Event-Related Brain Potentials in the Study of Inhibition: Cognitive Control, Source Localization and Age-Related Modulations

et al. 2014

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“…MMN is ideal for addressing whether working memory impairment is due to premature trace decay, in research protocols, varying the ISI [9,10]. We have to admit that our ISI of 2,400 ms might be seen as a potential limitation of this study as we did not test ISI around 3,000 ms as previously reported in aging, schizophrenia, neurodegenerative dementias and Parkinson's disease (see [10][11][12] for review).…”

Section: Young Adultsmentioning

confidence: 99%

“…MMN is ideal to address if working memory impairment is due to premature trace decay; in fact, by varying the interstimulus interval (ISI) between tones, MMN parameters can provide an index of auditory memory trace decay over time [9,10]. Decrease echoic discrimination has been detected in aging, Alzheimer's disease, Parkinson's disease, schizophrenia and aging (see [10][11][12] for review). In order to obtain the P3a evoked potential, novel stimuli are presented infrequently in a background of frequently occurring standard stimuli and infrequently occurring distractor stimuli, while the subject is not required to respond mentally or physically to any stimulus.…”

Section: Introductionmentioning

confidence: 99%

“…Since MMN is more evident when subjects ignore the auditory stimuli or perform a distracting task, it is supposed to be an index of preattentive processing. MMN is automatically generated whenever there is a mismatch between the neuronal model of the physical features of the standard stimulus and the deviant stimulus [9,10]. MMN is ideal to address if working memory impairment is due to premature trace decay; in fact, by varying the interstimulus interval (ISI) between tones, MMN parameters can provide an index of auditory memory trace decay over time [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…MMN is automatically generated whenever there is a mismatch between the neuronal model of the physical features of the standard stimulus and the deviant stimulus [9,10]. MMN is ideal to address if working memory impairment is due to premature trace decay; in fact, by varying the interstimulus interval (ISI) between tones, MMN parameters can provide an index of auditory memory trace decay over time [9,10]. Decrease echoic discrimination has been detected in aging, Alzheimer's disease, Parkinson's disease, schizophrenia and aging (see [10][11][12] for review).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Stability of Auditory Discrimination and Novelty Processing in Physiological Aging

Raggi

Tasca

Rundo

et al. 2013

Behavioural Neurology

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Abstract. Complex higher-order cognitive functions and their possible changes with aging are mandatory objectives of cognitive neuroscience. Event-related potentials (ERPs) allow investigators to probe the earliest stages of information processing. N100, Mismatch negativity (MMN) and P3a are auditory ERP components that reflect automatic sensory discrimination. The aim of the present study was to determine if N100, MMN and P3a parameters are stable in healthy aged subjects, compared to those of normal young adults. Normal young adults and older participants were assessed using standardized cognitive functional instruments and their ERPs were obtained with an auditory stimulation at two different interstimulus intervals, during a passive paradigm. All individuals were within the normal range on cognitive tests. No significant differences were found for any ERP parameters obtained from the two age groups. This study shows that aging is characterized by a stability of the auditory discrimination and novelty processing. This is important for the arrangement of normative for the detection of subtle preclinical changes due to abnormal brain aging.

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Investigating auditory electrophysiological measures of participants with mild cognitive impairment and Alzheimer’s disease: A systematic review and meta‐analysis of event‐related potential studies

Tarawneh

Mulders

Sohrabi

et al. 2021

Alzheimer's & Dementia

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Background: Objectively measuring auditory functions has been proposed as an avenue in differentiating normal age-related cognitive dysfunction from Alzheimer's disease (AD) and its prodromal states. Previous research has suggested auditory eventrelated potentials (AERPs) to be non-invasive, cost-effective and efficient biomarkers for the diagnosis of AD. The objective of this paper is to review the published literature on AERPs measures in older adults diagnosed with AD and those at higher risk of developing AD, i.e., mild cognitive impairment (MCI) and subjective cognitive decline (SCD). Method:The search was performed on six major electronic databases (Ovid MED-LINE, OVID EMBASE, PsycINFO, PubMed, Scopus and CINAHL Plus). Articles identified prior to 7th May 2019 were considered for this review. A random effects metaanalysis and analysis of between study heterogeneity was conducted using the Comprehensive Meta-Analysis software. Result:The search identified 1076 articles; 74 articles met the full inclusion criteria and were included in the systematic review, and 47 articles were included into the analyses. Pooled analysis suggests that AD participants can be differentiated from controls due to significant delays in ABR, N100, P200, N200 and P300 latencies. P300 amplitude was significantly smaller in AD participants compared to controls. P300 latencies differed significantly between MCI participants and controls based on the pooled analysis. Conclusion:The findings of this review indicate that some AERPs may be valuable biomarkers of AD. In conjunction with currently available clinical and neuropsychological assessments, AERPs can aid in screening and diagnosis of prodromal AD.

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The mismatch negativity (MMN) – A unique window to disturbed central auditory processing in ageing and different clinical conditions

Cited by 340 publications

References 754 publications

Event-Related Brain Potentials in the Study of Inhibition: Cognitive Control, Source Localization and Age-Related Modulations

Event-Related Brain Potentials in the Study of Inhibition: Cognitive Control, Source Localization and Age-Related Modulations

Stability of Auditory Discrimination and Novelty Processing in Physiological Aging

Investigating auditory electrophysiological measures of participants with mild cognitive impairment and Alzheimer’s disease: A systematic review and meta‐analysis of event‐related potential studies

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