Peculiar response to methylphenidate in adolescent compared to adult rats: a phMRI study

Canese, Rossella; Adriani, Walter; Marco, Eva M.; Pasquale, Francesco de; Lorenzini, Paola; Luca, N; Fabi, Fulvia; Podo, Franca; Laviola, Giovanni

doi:10.1007/s00213-008-1379-1

Cited by 33 publications

(27 citation statements)

References 67 publications

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“…Regardless of stress experience, adolescent animals showed enhanced basal values of HR relative to adult, what is in line with previous studies indicating resting tachycardia in adolescent rodents relative to adults (Canese et al, 2009; Ristuccia and Spear, 2008). Ontogenic differences in HR were followed by augmented power of oscillatory component at LF range of the PI, thus providing the first evidence that resting tachycardia in adolescent relative to adult is mediated by a higher sympathetic tone to the heart.…”

Section: Discussionsupporting

confidence: 91%

Immediate and long‐term effects of psychological stress during adolescence in cardiovascular function: Comparison of homotypic vs heterotypic stress regimens

Duarte

Planeta

Crestani

2014

Intl J of Devlp Neuroscience

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Adolescence has been proposed as an ontogenic period of vulnerability to stress. Nevertheless, the impact of stressful events during adolescence in cardiovascular activity is poorly understood. Therefore, the purpose of this study was to investigate the immediate and long-lasting effects of exposure to stressful events during adolescence in cardiovascular function of rats. To this end, we compared the impact of 10-days exposure to two chronic stress protocols: the repeated restraint stress (RRS, homotypic) and chronic variable stress (CVS, heterotypic). Independent groups of animals were tested 24h (immediate) or three weeks (long-lasting) following completion of stress period. Exposure to CVS, but not RRS, during adolescence increased basal HR values without affecting arterial pressure, which was followed by augmented power of oscillatory component at low frequency (sympathetic-related) of the pulse interval (PI). RRS enhanced variance of the PI with an increase in the power of both low and high (parasympathetic-related) frequency components. RRS also increased the baroreflex gain. Neither RRS nor CVS affected systolic arterial pressure variability. The RRS-evoked changes in PI variability were long-lasting and persisted into adulthood while all alterations evoked by the CVS were reversed in adulthood. These findings indicate a stress type-specific influence in immediate and long-term effects of stress during adolescence in cardiovascular function. While immediate changes in cardiovascular function were mainly observed following CVS, long-lasting autonomic consequences in adulthood were observed only in animals exposed to RRS during adolescence.

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Section: Discussionsupporting

confidence: 91%

Immediate and long‐term effects of psychological stress during adolescence in cardiovascular function: Comparison of homotypic vs heterotypic stress regimens

Duarte

Planeta

Crestani

2014

Intl J of Devlp Neuroscience

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“…We observed that adolescents showed higher HR values relative to adult animals, which is in line with previous studies (24,43,44). However, the present study provides the first evidence that resting tachycardia in adolescents is mediated by a higher cardiac sympathetic tone and increased iHR.…”

Section: Influence Of the Ontogenysupporting

confidence: 93%

Stress Vulnerability During Adolescence

Duarte

Cruz

Leão

et al. 2015

Psychosomatic Medicine

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“…These effects occurred earlier (< 12 minutes post dosing) in nucleus accumbens and prefrontal cortex, than they did in the hippocampus [83].…”

Section: Swanson and Colleagues [Summarised In 13] Investigated The mentioning

confidence: 73%

Stimulant Drug Effects on Attention Deficit/Hyperactivity Disorder: A Review of the Effects of Age and Sex of Patients

Cornforth¹,

Sonuga‐Barke²,

Coghill³

2010

CPD

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Objective: Because dopamine functioning varies by sex and age it might be expected that the effects of methylphenidate or amfetamine, the psychostimulants used for the treatment of Attention Deficit /Hyperactivity Disorder (ADHD), will also be moderated by these factors.Here we review the published literature on whether stimulant effects in ADHD symptoms vary by age and sex. Results: Randomised controlled trials confirm that stimulant medication is efficacious for, and well tolerated by, males and females and patients across the age range; although preschoolers appear to have a less beneficial response and more side effects. Few studies that specifically examined the moderating effect of age and/or sex were identified. For sex, no effects on overall response were found, although one study reported that sex moderated methylphenidate pharmacodynamics. The few effects found for age were small and inconsistent. Conclusions:The available evidence suggests that stimulant medication, when appropriately administered, has efficacy as an ADHD treatment for both sexes and across all ages. There are currently too few published papers examining the effects of sex and age to draw strong conclusions about moderation. Further studies of the pharmacodynamics of stimulants on ADHD MEDICATION MODERATORS 3 symptoms measured using objective tests in the laboratory or classroom setting need to be undertaken.

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Peculiar response to methylphenidate in adolescent compared to adult rats: a phMRI study

Cited by 33 publications

References 67 publications

Immediate and long‐term effects of psychological stress during adolescence in cardiovascular function: Comparison of homotypic vs heterotypic stress regimens

Immediate and long‐term effects of psychological stress during adolescence in cardiovascular function: Comparison of homotypic vs heterotypic stress regimens

Stress Vulnerability During Adolescence

Stimulant Drug Effects on Attention Deficit/Hyperactivity Disorder: A Review of the Effects of Age and Sex of Patients

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