Peculiar Findings in a Case of Bilateral Uveal Pigmented Lesions

Mora, Paolo; Gonzales, Stefania; Crafa, Pellegrino; Carta, Arturo; Guex-Crosier, Yan; Zografos, Léonidas

doi:10.3109/09273948.2010.490631

Cited by 11 publications

(4 citation statements)

References 5 publications

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“…Various treatments for BDUMP, including ocular radiation [1, 3, 19, 32], subretinal fluid drainage [30] and corticosteroids [15, 16, 24, 35] have been tried without success. Recently, plasmapheresis has been shown to improve visual acuity in few case reports.…”

Section: Discussionmentioning

confidence: 99%

Multimodal imaging of bilateral diffuse uveal melanocytic proliferation associated with an iris mass lesion

et al. 2016

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BackgroundBilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare, paraneoplastic syndrome characterized by bilateral painless visual loss and proliferation of choroidal melanocytes in association with an underlying systemic malignancy. We report a case of bilateral diffuse uveal melanocytic proliferation associated with an underlying gynecological malignancy that also features the infrequent finding of an iris mass lesion, using multimodal imaging including ultra-widefield imaging, spectral domain and swept-source optical coherence tomography.Case presentationA 59-year-old white female with a prior history of gynecological malignancy in remission presented with progressive bilateral visual loss over several weeks. The patient was noted to have a focal iris mass lesion in her right eye. Ultra-widefield color fundus photography showed a characteristic bilateral ‘giraffe pattern’ of pigmentary changes extending into the periphery as well as multiple discrete deeply pigmented lesions. Ultra-widefield autofluorescence was useful for visualizing the full extent of involvement. Indocyanine green angiography helped to demarcate the discrete pigmented choroidal lesions. Swept-source OCT clearly delineated the alternating zones of retinal pigment epithelium (RPE) thickening and RPE loss, as well as the prominent choroidal infiltration and thickening.ConclusionsBDUMP is an important diagnosis to consider in the presence of multiple discrete melanocytic choroidal lesions, diffuse choroidal thickening, characteristic RPE changes, iris mass lesions and exudative retinal detachment. Ultra-widefield imaging may demonstrate more extensive lesions than that detected on clinical examination or standard field imaging. Imaging with SS-OCT shows choroidal and RPE characteristics that correlate well with known histopathology of this entity.

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Section: Discussionmentioning

confidence: 99%

Multimodal imaging of bilateral diffuse uveal melanocytic proliferation associated with an iris mass lesion

et al. 2016

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“…In general, treatment of BDUMP has until now mainly been ineffective. 16 , 34 Various treatment modalities for BDUMP, including ocular radiation, 4 , 11 , 22 , 35 subretinal fluid drainage 36 and corticosteroids 37 , 38 , 39 , 40 have all failed to give consistent results. Vitrectomy and silicone oil tamponade for serous retinal detachment has been attempted with varying outcomes.…”

Section: Discussionmentioning

confidence: 99%

Presumed bilateral diffuse uveal melanocytic proliferation – A case report and review of literature

Parakh¹,

Maheshwari²,

Das³

et al. 2022

American Journal of Ophthalmology Case Reports

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“…1 The condition commonly occurs in females with gynecological carcinoma [2][3][4][5][6][7] or males with lung malignancy, [8][9][10] although several other cancer sites have been described. 1,11,12 Furthermore, the condition may occur as the first sign of yet undiscovered malignancy. 13 Our understanding of BDUMP has increased significantly in the last 5 years.…”

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confidence: 98%

Spectral Domain Optical Coherence Tomography Findings in a Case Series of Patients with Bilateral Diffuse Uveal Melanocytic Proliferation

Shalchi

Shunmugam

Mahroo

et al. 2014

Ocular Immunology and Inflammation

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Peculiar Findings in a Case of Bilateral Uveal Pigmented Lesions

Abstract: Although not all the criteria for the diagnosis were fulfilled, clinical findings were compatible with BDUMP. The presence of scleral pigmented lesions and the good visual prognosis may widen the spectrum of this rare disease.

Cited by 11 publications

References 5 publications

Multimodal imaging of bilateral diffuse uveal melanocytic proliferation associated with an iris mass lesion

Multimodal imaging of bilateral diffuse uveal melanocytic proliferation associated with an iris mass lesion

Presumed bilateral diffuse uveal melanocytic proliferation – A case report and review of literature

Spectral Domain Optical Coherence Tomography Findings in a Case Series of Patients with Bilateral Diffuse Uveal Melanocytic Proliferation

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