Spectral Domain Optical Coherence Tomography Findings in a Case Series of Patients with Bilateral Diffuse Uveal Melanocytic Proliferation

Presumed bilateral diffuse uveal melanocytic proliferation – A case report and review of literature

“… 11 Giraffe (or leopard-spot) pattern on SW-FAF, OCT findings of RPE aggregation with irregularity, subretinal fluid and preserved choriocapillaris architecture - present in our case - have been described in previous reports of BDUMP. 12 , 13 , 14 The most common primary malignancy associated with BDUMP in females is urogenital carcinoma (71%), whereas in males, lung carcinoma accounted for 51% of cases. 15 With better life expectancy and improved diagnostic modalities, the reported incidence of this disease has increased to 4.4 per year during 2012–2017.…”

Spectral-Domain-Optical Coherence Tomography in Uveitis

“…Shalchi et al 11 used SD-OCT to evaluate two women with Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP), a rare paraneoplastic disorder characterized by the occurrence of polygonal patches of RPE atrophy surrounded by aggregates of hypertrophied RPE cells -so called ''giraffe pattern'', diffuse thickening of the choroid with heavily pigmented melanocytes underlying areas of RPE atrophy, and rapidly progressive cataracts. Imaging in each patient showed localized disruption of the outer retinal hyper-reflective bands associated with a shallow serous retinal detachment.…”

“…Research in this area is extremely active, and focuses to a large extent on identifying and characterizing retinal and choroidal changes found in various uveitic conditions, as well as on the use of SD-OCT imaging in monitoring response to therapy and predicting long-term vision outcomes. Nine papers in this issue of Ocular Immunology & Inflammation, including five original articles [4][5][6][7][8] and four letters, [9][10][11][12] describe the use of high resolution OCT in patients with inflammatory diseases known to affect the eye.…”