Pectins and Xyloglucans Exhibit Antimutagenic Activities against Nitroaromatic Compounds

Abstract

Because a high daily consumption of polysaccharides-containing food is assessed to decrease the risk of cancer of the gastrointestinal system, different types of carbohydrates were investigated for their antimutagenic activity against different standard mutagens. Within the screening pronounced antimutagenic effects were found for xyloglucan and different pectins and pectin-like rhamnogalacturonans against 1-nitropyrene induced mutagenicity. Inhibition rates were dose-dependent and varied between 20 and 50%. Concerning the mode of action a direct interaction of the polymers with the cells is claimed, protecting the organisms from the mutagenic attack.

Evidence for Bioadhesive Effects of Polysaccharides and Polysaccharide-Containing Herbs in an ex vivo Bioadhesion Assay on Buccal Membranes

“…Similar structural prerequesites for biologically active polysaccharides have been observed in that way that interaction of polymers with the bacterial cell wall surface is only possible for linear polysaccharides with short side chains (10). It may be worth while to further investigate the correlation of the fine structures of different defined polymers with the respective bioadhesive effects in order to elucidate a clear structure-effect relation for further drug development.…”

Oligo- and polysaccharides exhibit a structure-dependent bioactivity on human keratinocytes in vitro

“…Main focus for such products are immunological activities (Duan et al, Abbreviations: NHK, primary normal human keratinocytes; HaCaT, human adult high calcium low temperature; HMOS, human milk oligosaccharides; CPS, crude polysaccharides; AEC, anion exchange chromatography; LDH, lactatedehydrogenase; TLC, thin layer chromatography; RG, rhamnogalacturonans * Corresponding author. 2003), antimutagenic (Hensel and Meier, 1999) and antiinflammatoric (Sendl et al, 1993) properties as well as protecting activity against epithelial membranes (Schmidgall et al, 2000), promoting influence on tissue regulation (Biagini et al, 1991) and wound healing. This leads more and more to targeted investigation of plant-derived polysaccharides on physiological activities within drug-discovery programs.…”

Juices in the diet of a child and an adult: Their significance for health

“…Пищевые волокна могут выступать в качестве сорбентов экзогенных и эндогенных мутагенов [56]. Яблочный пектин и пектин из других фруктов в экс-перименте оказались эффективны против прямого действия стандартного мутагена 1-нитропирена [57]. Кроме того, пищевые волокна связывают потен-циальные мутагены в желудочно-кишечном тракте и выводят их в составе каловых масс.…”