Pectin nanoparticle enhances cytotoxicity of methotrexate against hepG2 cells

Chittasupho, Chuda; Jaturanpinyo, Montree; Mangmool, Supachoke

doi:10.3109/10717544.2012.739214

Cited by 69 publications

(22 citation statements)

References 33 publications

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“…The conjugation and release of chemotherapeutic agent methotrexate (MTX) in pectinate NPs were investigated in a subsequent study. 90 The results verified that pectin can deliver MTX to HepG2 cells with high efficiency and specificity and exhibited sustained drug release. Recently, in vitro and in vivo evaluation of pectinate NPs loaded with anticancer drug 5-fluorouracil (5-FU) for HCC was carried out, and the pectin served as drug delivery vector of chemotherapy agent and natural targeting ligand to ASGPR in this NTDDS.…”

mentioning

confidence: 49%

“…Pectin, another polysaccharide with anion, water solubility, and non-toxicity, has attracted attention for targeted therapy in HCC. [89][90][91] It is a natural linear polymer mainly consisting of α-(1-4)-linked d-polygalacturonic acid residues in Figure 4 and extracted from citrus peels or apple pomaces. The d-polygalacturonic acid is an oxidized form of Gal, thus the pectin displays active targeting ability to hepatoma cells contributing to the specific interaction between galacturonic acid residues and ASGPR on the cells.…”

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confidence: 99%

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Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

Li¹,

Zhang²,

Wang³

et al. 2016

IJN

117

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confidence: 49%

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confidence: 99%

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

Li¹,

Zhang²,

Wang³

et al. 2016

IJN

117

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“…Cell viability was performed by the MTT assay according to the method previously described [19]. Cells were seeded in 96-well culture plates at a density of 1 × 10 4 cells/well, in a total volume of 200 μ l of DMEM supplemented with 1% FBS plus 1% penicillin/streptomycin.…”

Section: Methodsmentioning

confidence: 99%

Thai Fruits Exhibit Antioxidant Activity and Induction of Antioxidant Enzymes in HEK‐293 Cells

Anantachoke

Praserttirachai

Khammanit

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The cellular antioxidant enzymes play the important role of protecting the cells and organisms from the oxidative damage. Natural antioxidants contained in fruits have attracted considerable interest because of their presumed safety and potential nutritional value. Even though antioxidant activities of many fruits have been reported, the effects of phytochemicals contained in fruits on the induction of antioxidant enzymes in the cells have not been fully defined. In this study, we showed that extracts from Antidesma ghaesembilla, Averrhoa bilimbi, Malpighia glabra, Mangifera indica, Sandoricum koetjape, Syzygium malaccense, and Ziziphus jujuba inhibited H2O2-induced intracellular reactive oxygen species production in HEK-293 cells. Additionally, these Thai fruit extracts increased the mRNA and protein expressions of antioxidant enzymes, catalase, glutathione peroxidase-1, and manganese superoxide dismutase. The consumption of Thai fruits rich in phenolic compounds may reduce the risk of oxidative stress.

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“…Pectin, an important polysaccharide, mainly consists of ␣-(1-4)-linked dpolygalacturonic acid residues (Cheng & Lim, 2004;Fan et al, 2008;Yu et al, 2009). Nanoparticles containing pectin may target hepatocellular carcinoma cells (Chittasupho, Jaturanpinyo, & Mangmool, 2013;Verma & Kumar, 2013;Yu et al, 2014). Nevertheless, pectin nanoparticles are hydrophilic gel nanoparticles and can efficiently encapsulate water-soluble drugs.…”

Section: Introductionmentioning

confidence: 99%