Pectin-based hydrogels with adjustable properties for controlled delivery of nifedipine: development and optimization

Ajaz, Nyla; Khalid, Ikrima; Minhas, Muhammad Usman; Barkat, Kashif; Khan, Ikram Ullah; Syed, Haroon K.; Asghar, Sajid; Munir, Rabia; Aslam, Fahmida

doi:10.1007/s00289-019-03065-7

Cited by 17 publications

(9 citation statements)

References 40 publications

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“…This dynamic chemical bond forms the main body of the crosslinked hydrogel network, which imparts hydrogels with improved mechanical strength and rapid self-healing properties. Pectin forms strong hydrogen bonds with PVA chains, which can further improve the mechanical strength of the hydrogel . The abundant free Na + and B(OH) 4 – ions impart ionic conductivity to hydrogels.…”

Section: Resultsmentioning

confidence: 99%

“…28 Two biopolymers, pectin and tannic acid, were added to the PVA solution to simultaneously ensure the four functionalities. Pectin, an anionic polysaccharide mainly composed of α-(1,4)-D-galacturonic acid, was applied to improve the elastic behavior of the hydrogel matrix, 32 whereas tannic acid, a polyphenolic polymer with catechol groups, was applied to improve interfacial adhesion. 33 After the dissolution of all chemicals at 90 °C, the pH of the solution was adjusted to 8 using NaOH solution (0.1 M), ensuring the formation of borate ester bonds.…”

Section: Design and Mechanism Of Multifunctionalmentioning

confidence: 99%

“…Pectin forms strong hydrogen bonds with PVA chains, which can further improve the mechanical strength of the hydrogel. 32 The abundant free Na + and B(OH) 4 − ions impart ionic conductivity to hydrogels. In addition, the catechol group of tannic acid can dynamically crosslink with B(OH) 4…”

Section: Design and Mechanism Of Multifunctionalmentioning

confidence: 99%

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3D Printable Self-Adhesive and Self-Healing Ionotronic Hydrogels for Wearable Healthcare Devices

Seong

Kondaveeti

Choi

et al. 2023

ACS Appl. Mater. Interfaces

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Ionotronic hydrogels have attracted significant attention in emerging fields such as wearable devices, flexible electronics, and energy devices. To date, the design of multifunctional ionotronic hydrogels with strong interfacial adhesion, rapid self-healing, three-dimensional (3D) printing processability, and high conductivity are key requirements for future wearable devices. Herein, we report the rational design and facile synthesis of 3D printable, self-adhesive, self-healing, and conductive ionotronic hydrogels based on the synergistic dual reversible interactions of poly(vinyl alcohol), borax, pectin, and tannic acid. Multifunctional ionotronic hydrogels exhibit strong adhesion to various substrates with different roughness and chemical components, including porcine skin, glass, nitrile gloves, and plastics (normal adhesion strength of 55 kPa on the skin). In addition, the ionotronic hydrogels exhibit intrinsic ionic conductivity imparting strain-sensing properties with a gauge factor of 2.5 up to a wide detection range of approximately 2000%, as well as improved self-healing behavior. Based on these multifunctional properties, we further demonstrate the use of ionotronic hydrogels in the 3D printing process for implementing complex patterns as wearable strain sensors for human motion detection. This study is expected to provide a new avenue for the design of multifunctional ionotronic hydrogels, enabling their potential applications in wearable healthcare devices.

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Section: Resultsmentioning

confidence: 99%

Section: Design and Mechanism Of Multifunctionalmentioning

confidence: 99%

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3D Printable Self-Adhesive and Self-Healing Ionotronic Hydrogels for Wearable Healthcare Devices

Seong

Kondaveeti

Choi

et al. 2023

ACS Appl. Mater. Interfaces

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“…In all samples, the swelling ratio increased with time. In this context, CMC emerges as a notable weak polyelectrolyte, exhibiting high water absorption and swelling in aqueous media . P–Ca–CMC displayed the highest swelling (283.85 ± 3.21%) among the samples, attributed to the ionization of carboxyl groups at basic pH, leading to network repulsion and subsequent polymer swelling.…”

Section: Resultsmentioning

confidence: 99%

“…In this context, CMC emerges as a notable weak polyelectrolyte, exhibiting high water absorption and swelling in aqueous media. 51 P−Ca− CMC displayed the highest swelling (283.85 ± 3.21%) among the samples, attributed to the ionization of carboxyl groups at basic pH, leading to network repulsion and subsequent polymer swelling. Additionally, the presence of sugars in the patches demonstrated varying effects on the swelling ratios.…”

Section: Dissolving Ability Of Microneedle Patches In Skinmentioning

confidence: 99%

Transdermal Delivery of Catechin Using Dissolving Poly(vinyl alcohol)-Based Microneedles: Effect of Microneedle Composition on Drug Release

Sabbagh,

Saha,

Kim

2023

ACS Appl. Polym. Mater.

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The use of dissolving microneedles presents a highly desirable approach for transdermal drug delivery, offering enhanced patient safety and adherence. This study aimed to assess the release rate of catechin when combined with various constituents in a poly(vinyl alcohol) (PVA) microneedle patch. The impact of incorporating 2% dimethyl sulfoxide (DMSO), 5% carboxymethyl cellulose (CMC), 5% fructose, and 5% sucrose into the PVA microneedle patch was investigated. The manufactured microneedles underwent comprehensive characterization through techniques such as thermogravimetric analysis, scanning electron microscopy, Fourier transform infrared spectroscopy, measurement of thickness, evaluation of antioxidant activity, determination of swelling ratio, assessment of content uniformity, investigation of dissolving capability in skin, analysis of erosion, and release studies. An ex vivo investigation was conducted by using porcine skin and Franz diffusion cells to determine the release rate. The CMC-based microneedle patch displayed the highest catechin release (86.62 ± 4.69%) and swelling ratio (283.85 ± 3.21%). The analyses revealed that sugar enhances the microneedle structure effectively, although it renders the structure brittle and results in lower drug release compared with sugar-free microneedles. Consequently, the CMC-based formulation emerged as the optimal choice for the PVA microneedle patch.

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Synergistic action of hygroscopic and coalescing of biomass-based polymer in radioactive aerosol sedimentation

Wu,

Liang,

Liu

et al. 2024

J Radioanal Nucl Chem

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Pectin-based hydrogels with adjustable properties for controlled delivery of nifedipine: development and optimization

Cited by 17 publications

References 40 publications

3D Printable Self-Adhesive and Self-Healing Ionotronic Hydrogels for Wearable Healthcare Devices

3D Printable Self-Adhesive and Self-Healing Ionotronic Hydrogels for Wearable Healthcare Devices

Transdermal Delivery of Catechin Using Dissolving Poly(vinyl alcohol)-Based Microneedles: Effect of Microneedle Composition on Drug Release

Synergistic action of hygroscopic and coalescing of biomass-based polymer in radioactive aerosol sedimentation

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