Pectic oligosaccharide structure-function relationships: Prebiotics, inhibitors of Escherichia coli O157:H7 adhesion and reduction of Shiga toxin cytotoxicity in HT29 cells

Di, Rong; Vakkalanka, Malathi S.; Onumpai, Chatchaya; Chau, Hoa K.; White, André K.; Rastall, Robert A.; Yam, Kit L.; Hotchkiss, Arland T.

doi:10.1016/j.foodchem.2017.01.100

Cited by 86 publications

(73 citation statements)

References 40 publications

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“…In addition, GOS significantly reduced the adhesion of the murine bacterial pathogen Citrobacter rodentium to the epithelial cell surface in a dose-dependent manner in vitro, but not in vivo, which might be related to the expression of adhesins that are insensitive to GOS when C. rodentium grows in vivo (Kittana et al, 2018). of Shiga toxin-producing E. coli to human IECs (Di et al, 2017). Moreover, POS concentration dependently inhibited the adherence and invasion of C. jejuni to Caco-2 cells (Ganan et al, 2010).…”

Section: Dietary Fibre Acts As Anti-adhesives and Decoy Glycan Recementioning

confidence: 92%

“…POS have the ability to compete with Shiga toxin 2 binding to the neutral glycolipid globotriaosylceramide Gb3 receptor on the human IEC surface. Low MW and de‐esterification of POS facilitates the anti‐adhesive activity of Shiga toxin‐producing E. coli to human IECs (Di et al, ). Moreover, POS concentration dependently inhibited the adherence and invasion of C. jejuni to Caco‐2 cells (Ganan et al, ).…”

Section: Microbiota‐dependent Effects Of Dietary Fibre On Gut Homeostmentioning

confidence: 99%

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Microbiota‐dependent and ‐independent effects of dietary fibre on human health

Cai

Folkerts

et al. 2019

British J Pharmacology

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Dietary fibre, such as indigestible oligosaccharides and polysaccharides, occurs in many foods and has gained considerable importance related to its beneficial effects on host health and specific diseases. Dietary fibre is neither digested nor absorbed in the small intestine and modulates the composition of the gut microbiota. New evidence indicates that dietary fibre also interacts directly with the epithelium and immune cells throughout the gastrointestinal tract by microbiota‐independent effects. This review focuses on how dietary fibre improves human health and the reported health benefits that are connected to molecular pathways, in (a) a microbiota‐independent manner, via interaction with specific surface receptors on epithelial and immune cells regulating intestinal barrier and immune function, and (b) a microbiota‐dependent manner via maintaining intestinal homeostasis by promoting beneficial microbes, including Bifidobacteria and Lactobacilli, limiting the growth, adhesion, and cytotoxicity of pathogenic microbes, as well as stimulating fibre‐derived microbial short‐chain fatty acid production. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Section: Dietary Fibre Acts As Anti-adhesives and Decoy Glycan Recementioning

confidence: 92%

Section: Microbiota‐dependent Effects Of Dietary Fibre On Gut Homeostmentioning

confidence: 99%

Microbiota‐dependent and ‐independent effects of dietary fibre on human health

Cai

Folkerts

et al. 2019

British J Pharmacology

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“…This may make these NDCs suitable for the supplementation in infant formula in the near future. Recently Di et al (Di et al 2017) studied the potential prebiotic effects of 5 different pectin oligosaccharides (POS) structures, which can be obtained from pectin by enzymatic treatment and acid hydrolysis (Di et al 2017). It was found that POS exhibited prebiotic activity in in vitro batch fermentation studies and enhancing effects on numbers of Bifidobacteria over time.…”

Section: Effects Of Pos On Microbiota Compositionmentioning

confidence: 99%

“…However, the bifidogenic effect was not the same for all POSs tested and seems to be dependent on structure. Especially the arabinose-rich rhamnogalacturonic acids were responsible for the prebiotic effects (Di et al 2017 …”

Section: Effects Of Pos On Microbiota Compositionmentioning

confidence: 99%

Non-digestible carbohydrates in infant formula as substitution for human milk oligosaccharide functions: Effects on microbiota and gut maturation

Akkerman

Faas²,

Vos

2018

Critical Reviews in Food Science and Nutrition

131

140

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Human milk (HM) is the golden standard for nutrition of newborn infants. Human milk oligosaccharides (HMOs) are abundantly present in HM and exert multiple beneficial functions, such as support of colonization of the gut microbiota, reduction of pathogenic infections and support of immune development. HMO-composition is during lactation continuously adapted by the mother to accommodate the needs of the neonate. Unfortunately, for many valid reasons not all neonates can be fed with HM and are either totally or partly fed with cow-milk derived infant formulas, which do not contain HMOs. These cow-milk formulas are supplemented with non-digestible carbohydrates (NDCs) that have functional effects similar to that of some HMOs, since production of synthetic HMOs is challenging and still very expensive. However, NDCs cannot substitute all HMO functions. More efficacious NDCs may be developed and customized for specific groups of neonates such as pre-matures and allergy prone infants. Here current knowledge of HMO functions in the neonate in view of possible replacement of HMOs by NDCs in infant formulas is reviewed. Furthermore, methods to expedite identification of suitable NDCs and structure/function relationships are reviewed as in vivo studies in babies are impossible.

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“…For instance, different POS from orange peel have enhanced lactobacilli growth, while POS from orange peel with low MW and low deesterification showed the most anti‐adhesive activity for E . coli O157:H7 (Di et al, ).…”

Section: Oligosaccharides As Prebiotic Compoundsmentioning

confidence: 99%

Prebiotic compounds from agro‐industrial by‐products

2018

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Prebiotics are nondigestible food components that have an impact on gut microbiota composition and activity, which in turn results in the improvement of health conditions. Nowadays, the production of prebiotics from agro‐industrial by‐products is under investigation. In this regard, polysaccharides are usually found in these sources and their potential use as prebiotics has been studied recently since these compounds act as substrates for the human gut microbiota, and they have the potential to modulate its composition through many mechanisms. Additionally, the use of agricultural by‐products is advantageous because it is a cheap and abundantly available material. This review focuses on the recent scientific literature regarding the prebiotic properties of polysaccharides from agro‐industrial by‐products. Practical applications Currently, the maintenance of gut homeostasis is a target for the improvement of human health. This review can broaden the perspective on the utilization of agro‐industrial by‐products that can compete in the market with the commercial ones or act as a source for new food ingredients.

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Pectic oligosaccharide structure-function relationships: Prebiotics, inhibitors of Escherichia coli O157:H7 adhesion and reduction of Shiga toxin cytotoxicity in HT29 cells

Cited by 86 publications

References 40 publications

Microbiota‐dependent and ‐independent effects of dietary fibre on human health

Microbiota‐dependent and ‐independent effects of dietary fibre on human health

Non-digestible carbohydrates in infant formula as substitution for human milk oligosaccharide functions: Effects on microbiota and gut maturation

Prebiotic compounds from agro‐industrial by‐products

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