This paper reviews how well Biosphere Reserves are prepared to respond to the challenges of the new era of the Anthropocene, including the expected breaching of some planetary boundaries. In this context, the endeavour of sustainable development requires critical re-examination and Biosphere Reserves should move further towards embracing more integrated and effective forms of sustainable livelihoods for their inhabitants. This means placing people even more at the heart of Biosphere Reserve policy and management, and enabling people to become pioneers and ambassadors for realizing effective sustainability in all Biosphere Reserves. This also means that Biosphere Reserves and related institutions have to work towards true integration of their ecological, social and economic potentials, and set up a framework of genuine sustainability governance. This paper widens the concept of Biosphere Reserves to provide creative transformation towards more liveable, sustainable landscapes as a global network. If this is achieved, it will be easier for Biosphere Reserves to pursue and nurture the implementation of the Sustainable Development Goals (SDGs) as their renewed central purpose.