Peanut allergy: Clinical and immunologic differences among patients from 3 different geographic regions

Vereda, Andrea; Hage, Marianne van; Ahlstedt, S.; Ibáñez, María Dolores; Cuesta‐Herranz, Javier; Odijk, Jenny van; Wickman, Magnus; Sampson, Hugh A.

doi:10.1016/j.jaci.2010.09.010

Cited by 261 publications

(257 citation statements)

References 21 publications

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“…We confirmed in a well-defined group of patients allergic to peanut, hazelnut, and walnut that LTP is the main allergen in nut allergy, as has been previously reported in the Mediterranean area [6][7][8]10]. It is important to highlight that this study did not include children.…”

Section: Discussionsupporting

confidence: 84%

“…Furthermore, differences in allergenic profiles have been described for different geographical regions [6,7]. Lipid transfer proteins (LTPs) are the main allergens in tree nut allergy in the Mediterranean area [6,8,9], although it has been suggested that LTPs might also be markers of peach sensitization in the absence of clinical allergy [8,10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is Microarray Analysis Really Useful and Sufficient to Diagnose Nut Allergy in the Mediterranean Area?

Goikoetxea¹,

D'Amelio²,

Martínez‐Aranguren³

et al. 2016

J Investig Allergol Clin Immunol

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Is Microarray Analysis Really Useful and Sufficient to Diagnose Nut Allergy in the Mediterranean Area?

Goikoetxea¹,

D'Amelio²,

Martínez‐Aranguren³

et al. 2016

J Investig Allergol Clin Immunol

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“…For instance, peanut-allergic patients are commonly sensitised to Ara h 1, Ara h 2, and/or Ara h 3 in the USA, to Ara h 9 in Spain and to Ara h 8 in Sweden. This demonstrates heterogeneity in the immunological phenotype of peanut allergy in different geographical areas (Vereda et al, 2011a). …”

Section: Identified Allergensmentioning

confidence: 83%

Scientific Opinion on the evaluation of allergenic foods and food ingredients for labelling purposes

Products¹

2014

EFS2

102

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Following a request from the Food Safety Authority of Ireland, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA Panel) was asked to deliver a scientific opinion on the evaluation of allergenic foods and food ingredients for labelling purposes. In view of the request, the NDA Panel decided to update its previous opinions relative to food ingredients or substances with known allergenic potential listed in Annex IIIa of 2003/89/EC, as amended. These include cereals containing gluten, milk and dairy products, eggs, nuts, peanuts, soy, fish, crustaceans, molluscs, celery, lupin, sesame, mustard and sulphites. The opinion relates to immunoglobulin (Ig)E-and non-IgE-mediated food allergy, to coeliac disease and to adverse reactions to sulphites in food, and it does not address non-immune-mediated adverse reactions to food. It includes information on the prevalence of food allergy in unselected populations, proteins identified as food allergens, cross-reactivities, the effects of food processing on the allergenicity of foods and ingredients, methods for the detection of allergens and allergenic foods, doses observed to trigger adverse reactions in sensitive individuals and risk assessment methodologies that have been used to derive individual and population thresholds for selected allergenic foods. The present opinion relates to immunoglobulin (Ig)E-and non-IgE-mediated food allergy, to coeliac disease and to adverse reactions to sulphites in food, and it does not address non-immune-mediated adverse reactions to food. For each food ingredient or substance listed in Annex IIIa, it includes information on the prevalence of food allergy in unselected populations, on proteins identified as food allergens, on cross-reactivities, on the effects of food processing on the allergenicity of foods and ingredients, on methods for the detection of allergens and allergenic foods, and on doses observed to trigger adverse reactions in sensitive individuals.Immune-mediated adverse reactions to foods manifest with clinical signs and symptoms of variable severity and duration, which may affect different organs and systems. Anaphylactic reactions to food are IgE mediated and may occur at any age. Non-IgE-mediated food allergy includes a wide range of diseases, including protein-induced enterocolitis and eosinophilic oesophagitis.A careful family and clinical history are the basis for diagnosis of food allergy. Food diaries, skin prick tests (SPTs), allergen-specific IgE measurements, food elimination diets and food challenges are part of the standard protocol for the diagnosis of food allergy. A positive SPT indicates sensitisation to the tested food, but it is not diagnostic of food allergy. Allergen-specific serum IgE antibodies similarly denote sensitisation to a particular food, but they are not diagnostic without a clinical history or food challenge. The use of atopy patch tests for the diagnosis of food allergy is controversial. Other available tests have no current role in the diagnosis of food allergy. Diag...

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“…Ara h 8 is a pathogenesis-related protein, 16); Ara h 9 belongs to the lipid transfer protein (LTP) family, many of which are important allergens in the Mediterranean area (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

“…For example, peanut allergic children and adults have shown differences in allergen molecular recognition, with Ara h 2 the most prevalent in children (28) and Ara h 9 in adults (18). It is known that Ara h 9 sensitization is due to cross reactivity with Pru p 3, both LTPs (19,29). However, the reasons for the age-related differences in allergen recognition are complex and cannot be explained in term of allergen exposure and the cross-reactivity phenomenon only.…”

Section: Introductionmentioning

confidence: 99%

Influence of age on IgE response in peanut‐allergic children and adolescents from the Mediterranean area

García-Blanca

Aranda

Blanca‐López

et al. 2015

Pediatric Allergy Immunology

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Background Peanut allergens are common triggers of food allergy. Analyses of sensitization patterns, relationships with other allergens, clinical symptoms, and variation with age are needed. We studied sensitization to Ara h 2, Ara h 9, and Pru p 3 in a peanut allergic children/adolescents and the relationship with peach and pollen. Methods Peanut allergic patients aged between 1 and 20 years old were classified into two groups: A) allergic to peanut only and B) allergic to peach and peanut. The IgE response was measured to Ara h 2, Ara h 9, and Pru p 3. Results Of 964 subjects evaluated, 28% were allergic to peanut. From this group, 68% were also sensitized to pollen. Urticaria was the most frequent entity followed by anaphylaxis and OAS. Fifty‐eight percent had Ara h 2‐ and/or Ara h 9‐specific IgE. More than half reported symptoms with peanut alone (Group A) and 35% to peanut and peach (Group B). We observed significant differences in sex, age, onset of symptoms, and sensitization to Artemisia between groups. IgE response to Ara h 2 was more frequent in Group A, and Ara h 9 and Pru p 3 in Group B. We observed a decrease in sensitization to Ara h 2 and an increase to Ara h 9 and Pru p 3 with increasing age. Conclusion Peanut allergy is frequent in subjects with allergy to plant foods, with Ara h 2 and Ara h 9 being two important allergens. In younger patients, Ara h 2 predominates over Ara h 9. The reverse was observed in older patients.

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Peanut allergy: Clinical and immunologic differences among patients from 3 different geographic regions

Cited by 261 publications

References 21 publications

Is Microarray Analysis Really Useful and Sufficient to Diagnose Nut Allergy in the Mediterranean Area?

Is Microarray Analysis Really Useful and Sufficient to Diagnose Nut Allergy in the Mediterranean Area?

Scientific Opinion on the evaluation of allergenic foods and food ingredients for labelling purposes

Influence of age on IgE response in peanut‐allergic children and adolescents from the Mediterranean area

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