Is Microarray Analysis Really Useful and Sufficient to Diagnose Nut Allergy in the Mediterranean Area?

Goikoetxea, M. J.; D'Amelio, Carmen; Martínez‐Aranguren, Rubén; Pm, Gamboa; García, Blanca E.; Gómez, Francisco Alvarado; Fernández, J.; Bartra, Joan; Parra, A; Alvarado, María; Alonso, M I; González, Eva Abel Fernández; Terrados, S.; Moya, C; Blanca, Natalia; Brito, Francisco Feo; Villalba, Mayte; Díaz‐Perales, Araceli; Sánz, M L

doi:10.18176/jiaci.0005

Cited by 14 publications

(1 citation statement)

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“…This could be one of the causes of having found a lower sensitization to LTP and therefore that the primary sensitizer in hazelnut allergy in our patients has been storage proteins. In fact, the articles in which Cor a 8 is the predominant allergen in hazelnut allergic patients refer to the adult population [32][33][34], which would be in line with this hypothesis.…”

Section: Component-resolved Diagnosissupporting

confidence: 53%

Storage Proteins Are Driving Pediatric Hazelnut Allergy in a Lipid Transfer Protein-Rich Area

Valbuena

Reche

Martín

et al. 2021

Foods

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Oral food challenge (OFC) remains the gold standard for the diagnosis of food allergies. However, this test is not without risks, given that severe allergic reactions can be triggered while it is conducted. The purpose of this study is to identify potential demographic variables, clinical characteristics of the patients and biomarkers that may be associated with severe reactions during the hazelnut oral challenge test. The sample included 22 children allergic to hazelnut who underwent a tree nut skin prick test (SPT), specific IgE (sIgE) to hazelnut, component-resolved diagnosis (CRD) with different hazelnut allergens (Cor a 1, Cor a 8, Cor a 9, Cor a 11, Cor a 14), and a single-blind placebo-controlled challenge with hazelnut. A statistically significant relationship was found between the severity of the reaction and the highest values of sIgE to hazelnut, Cor a 11 and Cor a 14, cumulative symptom-triggering dose and sunflower seed sensitization. The use of the CRD is a useful tool to identify patients at higher risk of developing a severe reaction. In this pediatric population sample from Spain, storage proteins were confirmed to be most involved in hazelnut allergy and the development of severe reactions.

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Section: Component-resolved Diagnosissupporting

confidence: 53%