Peak value of blood myoglobin predicts acute renal failure induced by rhabdomyolysis

Kasaoka, Shunji; Todani, Masaki; Kaneko, Tadashi; Kawamura, Y.; Oda, Yasutaka; Tsuruta, Ryosuke; Maekawa, Taira

doi:10.1016/j.jcrc.2010.04.002

Cited by 62 publications

(48 citation statements)

References 11 publications

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“…Mb is known to play a key role in the development of acute renal damage due to its toxic accumulation in the renal tubular epithelium during the ultrafiltration process, [12] and it has been listed as a diagnostic marker and target for drug discovery for acute renal injury (ARI) [38] in conformity with the renal pathology which specifically showed severe pathologic renal injuries in the H&E stains.…”

Section: Discussionmentioning

confidence: 99%

“…It is also the most sensitive indicator in early diagnosis of acute tubular necrosis (ATN) [11]. In a clinical study of renal failure patient, the author showed a result with extreme levels of blood Mb higher than 10, 000 ng/mL and a predictability level of 0.88 based on area under the curve of acute renal failure with the best cutoff value of 3865 ng/mL for blood Mb [12]. On the other hand, urea nitrogen (UN) and serum creatinine (Scr) are indicators of renal impairment [13].…”

Section: Introductionmentioning

confidence: 99%

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Danhong Injection Protects Against Hypertension-Induced Renal Injury Via Down-Regulation of Myoglobin Expression in Spontaneously Hypertensive Rats

Orgah

Wang

Yang

et al. 2018

Kidney Blood Press Res

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Background/Aims: High blood pressure is a major risk factor for chronic kidney disease. Currently, single-target anti-hypertensive drugs are not designed for high blood pressure-related organ damages. Danhong injection (DHI), made from the aqueous extracts of Radix Salviae miltiorrhizae and Flos Carthamus tinctorius, has various pharmacological effects, including BP lowering in SHR, mediated by the reduction of vascular remodeling and the up-regulation of Kallikrein-kinin system published recently by our team, yet if it renders renal protection remains unknown. The current study demonstrated a protective role of DHI in renal injury caused by hypertension and identified its molecular targets in the kidney of spontaneously hypertensive rats (SHR). Methods: Adult SHR and age/gender-matched normotensive Wistar-Kyoto (WKY) rats were treated with DHI, Losartan, or saline for 4 weeks. Serum levels of Creatinine (CRE), Micro-albumin (mAlb), Beta2-microglobulin (β2-MG), and Uric acid (UA) were detected using ELISA kits. Renal pathology was examined by hematoxylin and Eosin (H&E) stains. Microarray analysis was performed on kidney tissues, and gene expression changes were validated by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot analyses. Results: Renal histopathological scores showed that SHR exhibited serious kidney injury compared to normotensive WKY rats. The intervention with DHI potently suppressed the renal injury biomarker (KIM-1) and kidney lesions compared to the untreated hypertensive subjects. Microarray analysis revealed that among the 124 genes that were differentially expressed by DHI treatment in SHR kidney, down-regulation of renal myoglobin (Mb) gene was the most prominent and was subsequently confirmed by qRT-PCR and Western blot analysis. Conclusion: Hypertension-induced renal injury in SHR may be alleviated by DHI in part by local suppression of Kidney injury molecule-1 and down-regulation of Myoglobin. However, if this effect is independent of the known anti-hypertensive action of DHI in blood vessel remains to be determined.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Danhong Injection Protects Against Hypertension-Induced Renal Injury Via Down-Regulation of Myoglobin Expression in Spontaneously Hypertensive Rats

Orgah

Wang

Yang

et al. 2018

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

“…Inicialmente es menor del 1 %, con sodio urinario menor de 20 mEq/L en la etapa de vasoconstricción (50). Posteriormente, por el daño tubular, la FeNA es mayor del 2 % y el sodio urinario sobrepasa los 30 mEq/L.…”

Section: Fracción Excretada De Sodio (Fena)unclassified

Insuficiencia renal aguda inducida por rabdomiolisis

Nieto-Ríos

Vega-Miranda

Higuita

2016

iatreia

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RESUMENLa insuficiencia renal aguda (IRA) es una causa frecuente de morbilidad y mortalidad en los servicios de urgencias, hospitalización y cuidado crítico, siendo la rabdomiolisis responsable del 15 % de los casos en los centros hospitalarios de alta complejidad. La rabdomiolisis consiste en daño muscular con necrosis y liberación a la circulación de componentes intracelulares, y puede tener múltiples causas. El daño renal por rabdomiolisis es multifactorial e incluye obstrucción tubular, vasoconstricción y daño oxidativo. El tratamiento principal de la IRA por rabdomiolisis es la hidratación, forzar la diuresis y evitar los fármacos nefrotóxicos. Cuando el daño es lo suficientemente grave para causar uremia, acidosis metabólica, hiperpotasemia y sobrecarga de volumen se debe recurrir a la terapia de reemplazo renal. Aunque la regla es que se recupere la función renal, estos pacientes tienen mayor riesgo futuro de desarrollar enfermedad renal crónica. PALABRAS CLAVEInsuficiencia Renal Aguda; Mioglobina; Músculo Esquelético; Necrosis; Rabdomiolisis SUMMARY Acute renal failure due to rhabdomyolyisisAcute renal failure is a frequent cause of morbidity and mortality in emergency, hospitalization and critical care services. In 15 % of cases it is due to rhabdomyolysis, in which there is breakdown of skeletal muscle with massive necrosis and leakage of muscle cell contents into the circulation. It has many different etiologies. The rhabdomyolysis-induced acute kidney injury results from the combination of several mechanisms, including tubular obstruction, vasoconstriction and oxidative stress. The most important therapeutic measures are: Aggressive repletion of fluids, forced diuresis and avoidance of exposure to nephrotoxic substances. In cases of

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“…Rhabdomyolysis classically defined as a CK levels greater than five times the upper limit of normal (approximately 850-1000 IU/L) (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). In our study, patients with rhabdomyolysis were defined as new proposed diagnostic criteria having absolute CK levels >15.000 IU/L or CK levels >5000 IU/L and any of the following: 1) crush injury, 2) AKI or overt failure, 3) myoglobinuria, 4) acidosis, disseminated intravascular coagulation (DIC), hypocalcemia, or hyperkalemia, 5) massive muscle injury, 6) prolonged extrication or initial evaluation delayed longer than 4 hours (20).…”

Section: Definitionsmentioning

confidence: 99%