Peak bone mineral density, lean body mass and fractures

Boot, Annemieke M.; Ridder, Maria A. J. de; Sluis, Inge M. van der; Slobbe, Ingrid van; Krenning, Eric P.; Keizer‐Schrama, Sabine M.P.F. de Muinck

doi:10.1016/j.bone.2009.10.003

Cited by 150 publications

(118 citation statements)

References 24 publications

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“…Table 4 Sensitivity* and specificity ** of a pediatric bone mass scan to predict adult bone mass. Bone mineral content (BMC; g), bone mineral density (BMD; g/cm 2 ) and bone width (cm) were measured by single photon absorptiometry (SPA) in distal forearm in 214 children with mean age 10.3 years (range 3-17) at baseline and mean 28 years (range [25][26][27][28][29] later at a mean age of 37 years (range 28-44) years. BMC, BMD and bone width Z-scores in childhood and adulthood were calculated for each individual using all 214 individuals as controls.…”

Section: Discussionmentioning

confidence: 99%

“…No follow-up measurements were originally planned but several decades later we designed the present study and conducted follow-up measurements by inviting all participants originally included. 214 of the original 296 participants were remeasured with the same SPA apparatus, a mean 28 years (range [25][26][27][28][29] later, then at a mean age of 37 years (range 28-44). Among the non-participants, 5 men and 2 women had died, 13 men and 9 women had relocated, 19 men and 15 women could not be located, 9 men and 8 women declined further participation, and 2 men were unable to attend due to illness.…”

Section: Methodsmentioning

confidence: 99%

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A Pediatric Bone Mass Scan Has Poor Ability to Predict Adult Bone Mass: A 28-Year Prospective Study in 214 Children

et al. 2013

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We conducted a prospective study following bone traits from childhood to adulthood.Our aim was to study if a bone mass scan in childhood can be used to predict bone mass in adulthood. We found that a pediatric bone mass scan has poor ability to predict adult bone mass. AbstractPurpose: As the correlation of bone mass from childhood to adulthood is unclear, we conducted a long-term prospective observational study to determine if a pediatric bone mass scan could predict adult bone mass. Methods:We measured cortical bone mineral content (BMC; g), bone mineral density (BMD; g/cm 2 ) and bone width (cm) in the distal forearm by single photon absorptiometry in 120 boys and 94 girls with a mean age of 10 years (range 3-17) and mean 28 years (range 25-29) later. We calculated individual and age specific bone mass Z-scores, using the control cohort included at baseline as reference and evaluated correlations between the two measurements with Pearson's correlation coefficient. Individual Z-scores were also stratified in quartiles to register movements between quartiles from growth to adulthood.Results: BMD Z-scores in childhood and adulthood correlated in both boys (r=0.35; p<0.0001) and girls (r=0.50, p<0.0001) and in both children ≥10 years at baseline (boys r=0.43 and girls r=0.58, both p<0.0001) and in children <10 years at baseline (boys r=0.26 and girls r=0.40, both p<0.05).Of the children in the lowest quartile of BMD, 58% had left the lowest quartile in adulthood. A pediatric bone scan with a value in the lowest quartile had a sensitivity of 48% (95% CI 27%, 69%) and a specificity of 76% (95% CI 66%, 84%) to identify individuals who would remain in the lowest quartile also in adulthood Conclusions: Childhood forearm BMD explained 12% of the variance in adult BMD in men and 25% in women.A pediatric distal forearm BMD scan has poor ability to predict adult bone mass.3

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

A Pediatric Bone Mass Scan Has Poor Ability to Predict Adult Bone Mass: A 28-Year Prospective Study in 214 Children

et al. 2013

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“…1 Salah satu efek samping dari terapi ini adalah penurunan nilai densitas mineral tulang (DMT) yang dapat diketahui melalui pengecekan Dual Energy X-Ray Absorptiometry (DEXA). 5,6 DMT merupakan cara pengukuran kalsium (mineral tulang) di dalam jaringan biologis dengan satuan g/cm 2 , dan berhubungan dengan kekuatan tulang, kapasitas beban tulang, serta risiko patah tulang. Penilaian DMT dapat dinyatakan dengan T-skor, dengan nilai T-skor -1 sampai dengan -2,5 tergolong ke dalam ostopenia, sedangkan nilai lebih dari -2,5 tergolong osteoporosis.…”

Section: Pendahuluanunclassified

“…6 Hal ini disebabkan jaringan tulang trabekular secara makroskopis terlihat berlubang-lubang (spons), namun terlihat lebih besar dan mengandung lebih sedikit lamel apabila dilihat secara mikroskopis.…”

Section: Kepatuhan Terapi Metilprednisolon Dapat Dilihat Berdasarkan unclassified

The Relationship of Lowering the Values of Bone Mineral Density in Methylprednisolone Medication Adherence on Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients

Soeroso

Suryana

Amalia

2018

Indones J Clin Pharm

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AbstrakMetilprednisolon merupakan glukokortikoid yang memiliki efek samping penurunan densitas mineral tulang (DMT). Tingkat kepatuhan berhubungan dengan terjadinya efek. Penelitian ini bertujuan untuk mengetahui hubungan penurunan nilai DMT dengan kepatuhan terapi metilprednisolon pada pasien artritis reumatoid dan lupus eritematosus sistemik. Penelitian ini dilakukan pada 43 pasien di Poliklinik Rheumatologi RSUD dr. Saiful Anwar Malang pada bulan Desember 2016-Januari 2017 dan termasuk penelitian deskriptif noneksperimental dengan analisis kualitatif dan kuantitatif menggunakan metode cross-sectional. Data diambil dari rekam medis pasien dan wawancara. Kriteria inklusi pada penelitian ini adalah perempuan berusia 31-50 tahun, menggunakan terapi metilprednisolon minimal selama 3 bulan serta memiliki data DMT. Kriteria eksklusi adalah menopause, riwayat fraktur tulang, merokok, mengonsumsi alkohol, sindrom cushing, hipertiroidisme, hiperparatiroidisme, gangguan kelenjar pituitari, dan osteoartritis serta mengonsumsi obat bifosfonat, heparin, anti-konvulsan, dan thiazid. Analisis data menggunakan uji korelasi Pearson dan regresi linier. Terdapat hubungan antara kepatuhan dengan area DMT Spine-L1 (r= -0,313; p=0,041), Spine-L2 (r= -0,349; p=0,022), Spine-L3 (r= -0,375; p=0,013), dan total spine (r = -0,380; p = 0,012). Metilprednisolon sensitif pada jaringan tulang trabekular yang menyusun area lumbar spine dibandingkan tulang kortikal. Hubungan rendah (r) antara tingkat kepatuhan dan DMT disebabkan sosial ekonomi, perawatan kesehatan, karakteristik penyakit, dan genetik. Kepatuhan terapi metilprednisolon menurunkan nilai DMT (lumbar spine) yang berakibat meningkatkan osteoporosis.Kata kunci: Artritis reumatoid, densitas mineral tulang, eritematosus sistemik, kepatuhan, lupus metilprednisolon The Relationship of Lowering the Values of Bone Mineral Density in Methylprednisolone Medication Adherence on Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients AbstractMethylprednisolone is a glucocorticoid which has a side effect of decreasing bone mineral density (DMT). The degree of compliance relates to the occurrence of effects. The objective of this study was to investigate the association of DMT impairment with adherence to methylprednisolone therapy in patients with rheumatoid arthritis (AR) and systemic lupus erythematosus (LES). The research was conducted to 43 patients in Rheumatology Polyclinic of dr. Saiful Anwar (RSSA) Malang. The study was conducted in December 2016-January 2017 and included nonexperimental description with qualitative and quantitative analysis using cross sectional method. The data were taken from the patient's medical record and interview. The inclusion criteria in this research were women, aged 31-50 years, using metilprednisolon therapy for at least three months and have mineral bone density data. Exclusion criteria were menopause, history of bone fracture, smoking, alcohol consumption, cushing syndrome, hyperthyroidism, hyperparathyroidism, pituitary gland disorders, and oste...

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“…Estudos apontam que o aumento em um desvio padrão (DP) no pico de massa óssea (ápice da formação do osso, que ocorre geralmente entre os 18 e 20 anos) pode reduzir em até 50% o risco de fraturas ao longo da vida (Boot et al, 2010;Baxter-Jones et al, 2011).…”

Section: Introductionunclassified

Carência de cálcio e vitamina D em crianças e adolescentes: uma realidade nacional

França¹,

Peters²,

Martini³

2014

Anais Do 2° Congresso Internacional Sabará De Especialidades Pediátricas

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ResumoO cálcio e a vitamina D são nutrientes essenciais para a saúde óssea, e o adequado fornecimento destes implica em melhor formação do esqueleto e, consequentemente, em adequado crescimento infantil e prevenção da ocorrência de osteoporose na vida adulta. Há, porém, evidências de elevada prevalência de inadequação de ingestão destes nutrientes entre a população de crianças e adolescente brasileiros, o que reflete mudanças comportamentais e de hábitos dietéticos e tem como consequência principal os possíveis impactos sobre a saúde óssea ao decorrer da vida.Palavras chave: deficiência de vitamina D; deficiência de cálcio; infância; adolescência

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Peak bone mineral density, lean body mass and fractures

Cited by 150 publications

References 24 publications

A Pediatric Bone Mass Scan Has Poor Ability to Predict Adult Bone Mass: A 28-Year Prospective Study in 214 Children

A Pediatric Bone Mass Scan Has Poor Ability to Predict Adult Bone Mass: A 28-Year Prospective Study in 214 Children

The Relationship of Lowering the Values of Bone Mineral Density in Methylprednisolone Medication Adherence on Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients

Carência de cálcio e vitamina D em crianças e adolescentes: uma realidade nacional

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