Peak Bone Mass and Bone Microarchitecture in Adults Born With Low Birth Weight Preterm or at Term: A Cohort Study

Balasuriya, Chandima Nirupa Dilruks; Evensen, Kari Anne I.; Mosti, Mats Peder; Brubakk, Ann‐Mari; Jacobsen, Geir; Indredavik, Marit S.; Schei, Berit; Stunes, Astrid Kamilla; Syversen, Unni

doi:10.1210/jc.2016-3827

Cited by 57 publications

(58 citation statements)

References 32 publications

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“…Lower bone accretion in preterm infants born SGA than in infants born AGA, independent of body size, suggest that prenatal conditions for bone accretion may not be replicated postnatally [84]. Lower body weight in infants born SGA was suggested as a potential risk factor for fracture [85] and an increased predisposition for fracture as a result of lower peak bone mass and higher risk of osteopenia was reported in young adults born SGA [86]. A study involving 15 preterm infants born SGA suggested that they may be at increased risk of low bone mass in adult life [87], with some data supporting that early life weight gain, especially peak weight velocity may be related to bone health, as assessed by vertebral cross sectional area, in adult life [88].…”

Section: Bone Strengthmentioning

confidence: 99%

What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature

Darendelıler

Kandemir

Harris

et al. 2019

Journal of Pediatric Endocrinology and Metabolism

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BackgroundAn increasing body of evidence supports the view that both an adverse intrauterine milieu and rapid postnatal weight gain in children born small for gestational age (SGA) contribute towards the risk for the development of chronic diseases in adult life.ContentThe aim of this review was to identify and summarize the published evidence on metabolic and cardiovascular risk, as well as risk of impaired cardiac function, intellectual capacity, quality of life, pubertal development and bone strength among children born SGA. The review will then address whether growth hormone (GH) therapy, commonly prescribed to reduce the height deficit in children born SGA who do not catch up in height, increases or decreases these risks over time.SummaryOverall, there are limited data in support of a modest beneficial effect of GH therapy on the adverse metabolic and cardiovascular risk observed in short children born SGA. Evidence to support a positive effect of GH on bone strength and psychosocial outcomes is less convincing.OutlookFurther evaluation into the clinical relevance of any potential long-term benefits of GH therapy on metabolic and cardiovascular endpoints is warranted.

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Section: Bone Strengthmentioning

confidence: 99%

What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature

Darendelıler

Kandemir

Harris

et al. 2019

Journal of Pediatric Endocrinology and Metabolism

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“…A recent body of research suggests that lower BW is associated with a variety of diseases of adulthood, including cardiovascular diseases, diabetes, hypertension, and other metabolic disorders (Godfrey & Barker, ). Additionally, low BW has been associated with potential risk for depression and anxiety in adulthood (Van Lieshout et al, ), increased fracture risk (Balasuriya et al, ), and neurodevelopmental difficulties including Attention Deficit Hyperactivity disorder (Momany, Kamradt, & Nikolas, ), among other health‐related conditions.…”

Section: Introductionmentioning

confidence: 99%

The influence of maternal height on offspring's birth weight in Merida, Mexico

Azcorra

Méndez-Domínguez

2018

American J Hum Biol

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Objectives: To analyze the influence of maternal height (MH) on offspring's birth weight (BW) in infants born from January 2016 to May 2017, in Merida, Mexico. Methods: A total of 3462 singletons born at term in a public hospital were analyzed. Data extracted from hospital records were MH; number of previous births; and infant's sex, BW, and gestational length. MH was divided into 4 categories at quartile points: Q1:129-147, Q2:148-151, Q3:152-155, and Q4:156-180 cm. BW data were transformed to z-score values using the WHO Child Growth Standard. The association between MH and infants' BW was analyzed through a multiple regression model in which gestational length, infant's sex, maternal age, ethnicity, and number of previous birth were included as covariates. Results: Mean values of MH and infants' BW were 151.43 cm (SD = 6.32) and 3172 g (SD = 401) (corresponding to −0.29 SD in BW z-score), respectively. The regression model showed that the shortest quartile of MH was associated with −0.43 (95% CI −0.35 −0.51) SD in infants' BW compared with the highest quartile. The second and third shortest quartiles of MH were associated with −0.24 (95% CI −0.16 −0.32) and −0.17 (95% CI −0.09 −0.25) SD of infants BW, respectively. Conclusions: MH remains an important factor for infant BW even in the presence of other determinants. The influence of MH on infants' BW in this population is similar to that found in other populations in low-, middle-, and high-income countries. K E Y W O R D Sbirth weight, maternal short height, Mexico, poverty, Yucatan

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“…Однако в настоящем исследовании, ожирение в подростковом возрасте по анамнестическим данным не встречалось, а дефицит массы тела выявлен только в 1 группе, у 11 пациенток. Была выявлена взаимосвязь между дефицитом массы тела в подростковом возрасте и МПК у родильниц, что вероятно связано с нарушением формирования пика костной массы [13].…”

Section: обсуждение основного результата исследованияunclassified

Factors influencing bone mineral density in postpartum women

et al. 2018

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Background: Osteopenia is a common condition. Therefore, identification of groups for prevention of osteoporosis and restoration of bone mineral density (BMD) remains relevant. Aim: to assess the factors contributing to development of osteopenia in puerperas. Methods: prospective cross-sectional study. We examined 112 patients aged 20-35, 3-5 days after delivery. To assess possible factors for BMD decrease, we analyzed medical history, lifestyle, nutrition, anthropometric data, obstetric and gynecological history, and pregnancy course. We also assessed serum levels of 25-hydroxycalciferol (25-OH-D) and PTH. BMD was measured by dual energy x-ray osteodensitometry. We considered Z-score from -1 to -2.5SD as osteopenia, below -2.5 SD-as osteoporosis. Results: based on Z-score values, two groups were formed: 1 (n=70) - puerperas with osteopenia, 2 (n=42) - puerperas with normal BMD. In the first group, osteopenia in the distal radius was observed in 48%, in the lumbar spine in 16% and in the proximal femur in 36%. Influence of the following possible factors in group 1 was established: BMI in 15-20 years ≤ 18 kg/m2 (p<0.013), BMI ≥ 25 kg/m2 (p<0.018), 25-OH-D less than 25 ng / ml (p < 0.0018), calcium intake less than 800 mg/day (p<0.041). Menstrual disorders (p<0.052) and preeclapsia (p < 0.042) affected lumbar spine BMD. In group 1, vitamin D deficiency was detected in 82% of women, 18% showed vitamin D insufficiency; in group 2, vitamin D deficiency was found in 16%, deficiency in 70%, in 14% vitamin D was normal. In women with a combination of factors such as BMI≤ 18 kg/m; calcium intake lower than 800 mg/day, menstrual cycle disorders, vitamin D deficiency - osteopenia in the distal radius occured 11 times more often (OR=11,47059; CI 95%=[4,0326; 32,627]). Conclusion: most significant impact on BMD decrease in puerperas can be expected if patient has the following risk factors: BMI≤18 kg/m2; 25-OH- D<25 ng/ml ; nutrition with calcium intake <800 mg per day, preeclampsia. Combination of these factors may increase the risk of osteopenia in the distal radius.

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Peak Bone Mass and Bone Microarchitecture in Adults Born With Low Birth Weight Preterm or at Term: A Cohort Study

Abstract: Both low-birth-weight groups displayed lower PBM and higher frequency of osteopenia/osteoporosis, implying increased future fracture risk. The most pronounced bone deficit was seen in VLBW adults.

Cited by 57 publications

References 32 publications

What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature

What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature

The influence of maternal height on offspring's birth weight in Merida, Mexico

Factors influencing bone mineral density in postpartum women

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