Peach (Prunus persica) extract inhibits angiotensin II-induced signal transduction in vascular smooth muscle cells

Kono, Ryohei; Okuno, Yoshiharu; Nakamura, Misa; Inada, Ken Ichi; Tokuda, Akihiko; Yamashita, Miki; Hidaka, Ryu; Utsunomiya, Hirotoshi

doi:10.1016/j.foodchem.2013.02.019

Cited by 11 publications

(8 citation statements)

References 27 publications

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“…With regard to non peptide substances, inhibition of angiotensin II-induced vasoconstriction has been reported to underlie the antihypertensive effects of compounds like nitro-oleic acid, a NO-derived fatty acid, 27 and especially plant extracts used in folk medicine. [28][29][30][31][32] Moreover, proanthocyanidins and alkaloids from some plant extracts are angiotensin AT1 receptor binding compounds. [33][34][35] On the other hand, inhibitory effects on renin activity, the rate limiting enzyme upstream the RAS, 36 have been reported for hemp seed protein hydrolysates, 37 flaxseed protein hydrolysate fractions 38 and peptides from pea protein hydrolysates, 39 as well as for peptides from a protein hydrolysate of the macroalga Palmaria palmate.…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive Mechanism of Lactoferrin-Derived Peptides: Angiotensin Receptor Blocking Effect

Fernández-Musoles

Castelló-Ruiz

Arce

et al. 2013

J. Agric. Food Chem.

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Looking for antihypertensive mechanisms beyond ACE inhibition, we assessed whether lactoferrin (LF)-derived peptides can act as receptor blockers to inhibit vasoconstriction induced by angiotensin II or endothelin-1. The lactoferricin B (LfcinB)-derived peptide LfcinB20-25 (RRWQWR), the low molecular weight LF hydrolysate (LFH < 3 kDa), and two peptides identified in LFH < 3 kDa (LIWKL and RPYL) were tested in ex vivo assays of vasoactive responses. The peptide RPYL was tested in radioligand receptor binding assays. Both LFH < 3 kDa and individual peptides inhibited angiotensin II-induced vasoconstriction. RPYL showed the highest ex vivo inhibitory effect and also inhibited binding of [(125)I]-(Sar(1),Ile(8))-angiotensin II to AT1 receptors. By contrast, neither LFH < 3 kDa nor RPYL inhibited endothelin-1 and depolarization-induced vasoconstrictions. In conclusion, LF-derived peptides selectively inhibit angiotensin II-induced vasoconstriction by blocking angiotensin AT1 receptors. Therefore, inhibition of angiotensin II-induced vasocontriction is suggested as a mechanism contributing along with ACE inhibition to the antihypertensive effect of some LF-derived peptides.

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Section: Discussionmentioning

confidence: 99%

Antihypertensive Mechanism of Lactoferrin-Derived Peptides: Angiotensin Receptor Blocking Effect

Fernández-Musoles

Castelló-Ruiz

Arce

et al. 2013

J. Agric. Food Chem.

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“…Several medicinal plants belonging to the Prunus genus have shown vascular activities: P. yedoensis bark relaxed vascular blood vessels by activating the NO formation from L-arginine and the NO-cGMP pathway, and blocking Ca 2+ entry through extracellular Ca 2+ channels [16]; the P. cerasus fruit (Montmorency tart cherry) significantly lowered systolic blood pressure in men with early hypertension [17]; and P. serotina fruits (Black cherry) induced vasodilation by activating the NO/cGMP and H 2 S/K ATP channel pathways [18]. The P. persica fruit (peach) has also shown cardiovascular protective effects by inhibiting angiotensin II-induced signal transduction in vascular smooth muscle cells (VSMCs) [19]. Here, we assessed for the first time the vascular activities of PPE by testing the vasorelaxant effect and investigating the associated mechanisms using an isolated organ-chamber technique.…”

Section: Discussionmentioning

confidence: 99%

“…A few plants from the genus Prunus , such as P. yedoensis [16], P. cerasus [17], and P. serotina [18], have shown vasorelaxant and vasodilatory effects. Although a cardiovascular protective activity of peach by inhibiting angiotensin II-induced signal transduction has been previously reported [19], to date, no study has investigated the vasorelaxation effects of the P. persica branch extract (PPE).…”

Section: Introductionmentioning

confidence: 99%

Endothelium-Dependent Vasorelaxant Effect of Prunus Persica Branch on Isolated Rat Thoracic Aorta

Kim

Lee

et al. 2019

Nutrients

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Peach (Prunus persica (L.) Batsch) is a popular fruit consumed by people worldwide, owing to its pleasant flavor and high mineral nutrient content. A few plants from the genus Prunus, such as Prunus yedoensis, Prunus cerasus, and Prunus serotina have shown vasorelaxant and vasodilatory effects, to date, no study has investigated the vasorelaxation effects of the P. persica branch extract (PPE). The vasorelaxant effect of PPE was endothelium-dependent, and it was related to the NO-sGC-cGMP, vascular prostacyclin, and muscarinic receptor transduction pathway. K+ channels, such as the BKCa, KV, and KATP channels, were partially associated with PPE-induced vasorelaxation. PPE was effective in relaxing serotonin (5-HT)- or angiotensin II-induced contraction; furthermore, PPE attenuated Ca2+-induced vasoconstriction by IP3 receptors in the SR membrane, but its vasorelaxant effect was not associated with the influx of extracellular Ca2+ via receptor-operative Ca2+ channels or voltage-dependent Ca2+ channels. Recognizing the rising use of functional foods for hypertension treatment, our findings imply that PPE may be a natural antihypertensive agent.

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“…P. persica fruits have moderate effects on blood circulation, recovery from exhaustion, detoxification, reinforcement of immune ability, and cosmetic treatment of the skin 26. However, the effect of P. persica fruits on the detoxification of smoking has not yet been reported.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of White-fleshed Peach (Prunus persica(L.) Batsch) on Chronic Nicotine-induced Toxicity

et al. 2017

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BackgroundNicotine is a major toxic component of tobacco smoke and has been recognized as a risk factor to induce oxidative tissue damage, which is a precursor to cardiovascular diseases, lung-related diseases, and cancers. Peaches (Prunus persica) have been used for the treatment of degenerative disorders, such as hypermenorrhea, dysmenorrhea, and infertility in Asian countries. In this study, we investigated the effects of white-fleshed peach on the excretion of nicotine metabolites and 1-hydroxypyrene in smokers and chronic nicotine-induced tissue damages in mice.MethodsThe concentrations of cotinine and 1-hydroxypyrene were measured in urine of smokers before or after intake of white-fleshed peaches. In addition, ICR mice were injected with nicotine (5 mg/kg body weight) and then orally administered with white-fleshed peach extracts (WFPE) (250 or 500 mg/kg body weight) for 36 days. The oxidative stress parameters and the activities of antioxidant enzymes were measured in liver and kidney tissues. Also, histological changes and nitrotyrosine expression were assessed.ResultsIntake of white-fleshed peaches increased the urinary concentration of nicotine metabolites and 1-hydroxypyrene in 91.67% and 83.33% of smokers, respectively. WFPE decreased the malondialdehyde levels and recovered the activities of antioxidant enzymes in nicotine-injected mice. In addition, WFPE inhibited nitrotyrosine expression and inflammatory responses in the liver, kidney, and lung tissues of nicotine-treated mice.ConclusionsWhite-fleshed peaches may increase the metabolism of toxic components in tobacco smoke in smokers and protect normal tissues against nicotine toxicity in mice. Therefore, supplementation of white-fleshed peaches might be beneficial to smokers.

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Peach (Prunus persica) extract inhibits angiotensin II-induced signal transduction in vascular smooth muscle cells

Cited by 11 publications

References 27 publications

Antihypertensive Mechanism of Lactoferrin-Derived Peptides: Angiotensin Receptor Blocking Effect

Antihypertensive Mechanism of Lactoferrin-Derived Peptides: Angiotensin Receptor Blocking Effect

Endothelium-Dependent Vasorelaxant Effect of Prunus Persica Branch on Isolated Rat Thoracic Aorta

Protective Effect of White-fleshed Peach (Prunus persica(L.) Batsch) on Chronic Nicotine-induced Toxicity

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