Endothelium-Dependent Vasorelaxant Effect of Prunus Persica Branch on Isolated Rat Thoracic Aorta

Kim, Bumjung; Kim, Kwang-Woo; Lee, Somin; Jo, Cheolmin; Lee, Kyungjin; Ham, In-Hye; Choi, Ho‐Young

doi:10.3390/nu11081816

Cited by 14 publications

(8 citation statements)

References 27 publications

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“…In vitro and ex vivo studies also showed the anti-inflammatory properties of P. persica extracts ( Gasparotto et al., 2014 ). Pharmacological studies showed that P. persica has antihypertensive properties ( Kim et al., 2019 ), and it influences the central cholinergic system ( Kim et al., 2003c ). Moreover, intake of peaches protects rat tissues from nicotine toxicity ( Kim et al., 2017 ).…”

Section: Health Promoting Properties Of Fruit Phytochemicalsmentioning

confidence: 99%

Stone Fruit as Biofactories of Phytochemicals With Potential Roles in Human Nutrition and Health

et al. 2020

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Phytochemicals or secondary metabolites present in fruit are key components contributing to sensory attributes like aroma, taste, and color. In addition, these compounds improve human nutrition and health. Stone fruits are an important source of an array of secondary metabolites that may reduce the risk of different diseases. The first part of this review is dedicated to the description of the main secondary organic compounds found in plants which include (a) phenolic compounds, (b) terpenoids/isoprenoids, and (c) nitrogen or sulfur containing compounds, and their principal biosynthetic pathways and their regulation in stone fruit. Then, the type and levels of bioactive compounds in different stone fruits of the Rosaceae family such as peach ( Prunus persica ), plum ( P. domestica , P. salicina and P. cerasifera) , sweet cherries ( P. avium ), almond kernels ( P. dulcis , syn. P. amygdalus ), and apricot ( P. armeniaca ) are presented. The last part of this review encompasses pre- and postharvest treatments affecting the phytochemical composition in stone fruit. Appropriate management of these factors during pre- and postharvest handling, along with further characterization of phytochemicals and the regulation of their synthesis in different cultivars, could help to increase the levels of these compounds, leading to the future improvement of stone fruit not only to enhance organoleptic characteristics but also to benefit human health.

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Section: Health Promoting Properties Of Fruit Phytochemicalsmentioning

confidence: 99%

Stone Fruit as Biofactories of Phytochemicals With Potential Roles in Human Nutrition and Health

et al. 2020

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“…The cytotoxicity of all compounds against human tumor cell lines was evaluated, and new compound 3 exhibited evident cytotoxicity to all tumor cell lines [ 27 ]. Prunus persica (L.) Batsch extract was effective in relaxing serotonin (5-HT)- or angiotensin II-induced contraction; furthermore, the extract attenuated Ca 2+ -induced vasoconstriction by IP3 receptors in the SR membrane [ 28 ]. The findings imply that Prunus persica (L.) Batsch extract may be a natural anti-blood stasis agent.…”

Section: Discussionmentioning

confidence: 99%

Anticancer Activity of Modified Tongyou Decoction on Eca109 Esophageal Cancer Cell Invasion and Metastasis through Regulation of the Epithelial‐Mesenchymal Transition Mediated by the HIF‐1α‐Snail Axis

Jia

Yan

Cao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. To explore the activity of Modified Tongyou Decoction (MTD) against Eca109 esophageal cancer (EC) cell invasion and metastasis and to ascertain the mechanism of its anticancer activity during the epithelial-mesenchymal transition (EMT) as mediated by the HIF-1α-Snail axis. Methods. Herbal compounds were prepared by ethanol extraction, and 6 herbs composing into MTD were dipped in water-free ethanol and filtered. The filtrate was collected and centrifuged. The remains were concentrated into a paste which was adjusted to 5000mg/mL concentration with DMSO. PBS was used to dilute the herbal solution to the half maximal inhibitory concentration. A hypoxic microenvironment was induced with CoCl2 in RPMI 1640 medium, in which Eca109 cells were cultured. The cytotoxicity of MTD was determined with CCK-8 assay. The activity of MTD against cell invasion and metastasis was explored with scratch assay and transwell assay. Western blot analysis was conducted to analyze the anticancer effects of MTD on the expression of HIF-1α-Snail axis- and EMT-related proteins. Quantitative RT-PCR was used to assess the mRNA expression of Snail. Immunofluorescence labeling was performed to examine how MTD affected the coexpression of Snail and HIF-1α. Results. The fifty percent inhibitory dose of MTD was 1410 μg/mL in the normoxic environment and 1823 μg/mL in the hypoxic environment based on the CCK-8 assay. The scratch assay showed that MTD significantly inhibited cell migration in both the normoxic and hypoxic microenvironments compared with the control groups ( P < 0.05). The transwell assay showed that MTD significantly inhibited cell invasion in both the normoxic and hypoxic environments compared with the control groups ( P < 0.05). Western blot showed that MTD significantly inhibited the expression of the HIF-1α, Snail, Vimentin, MMP-2, MMP-9, and VE-cadherin proteins and significantly induced the expression of E-cadherin in both the normoxic and hypoxic microenvironments compared with the control groups ( P < 0.05). qRT-PCR indicated that MTD significantly inhibited Snail mRNA expression compared with that in the control groups ( P < 0.05). Immunofluorescence assay showed that MTD significantly inhibited the coexpression of HIF-1α and Snail in both the normoxic and hypoxic microenvironments compared with the control groups ( P < 0.05). Conclusion. MTD downregulated HIF-1α-Snail axis- and EMT-related proteins to inhibit EC cell invasion and metastasis in both the normoxic and hypoxic environments.

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“…Aiming to discover a new natural antihypertensive agent, Kim et al [ 128 ] tested the vasorelaxant effect of pruned wood extract from peach trees and studied its associated mechanisms. Their findings demonstrated that ethanolic extract caused a concentration-dependent vasorelaxation of rat aortic rings.…”

Section: The Main Fruit Trees In Europe: Bioactive Compounds From Woo...mentioning

confidence: 99%

“…Their findings demonstrated that ethanolic extract caused a concentration-dependent vasorelaxation of rat aortic rings. Peach wood waste could thus be valorized as a functional food for hypertension treatment and could be implemented in nutraceutical or pharmaceutical areas [ 128 ].…”

Section: The Main Fruit Trees In Europe: Bioactive Compounds From Woo...mentioning

confidence: 99%

Wood Waste from Fruit Trees: Biomolecules and Their Applications in Agri-Food Industry

et al. 2022

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In the European Union (EU), a total of 11,301,345 hectares are dedicated to the cultivation of fruit trees, mainly olive orchards, grapevines, nut trees (almond, walnut, chestnut, hazelnut, and pistachio), apple and pear trees, stone fruit trees (peach, nectarine, apricot, cherry, and plum), and citrus fruit trees (orange, clementine, satsuma, mandarin, lemon, grapefruit, and pomelo). Pruning these trees, together with plantation removal to a lesser extent, produces a huge amount of wood waste. A theoretical calculation of the wood waste in the European Union estimates approximately 2 and 25 million tons from wood plantation removal and pruning, respectively, per year. This wood waste is usually destroyed by in-field burning or crushing into the soil, which result in no direct economic benefits. However, wood from tree pruning, which is enriched in high added-value molecules, offers a wide spectrum of possibilities for its valorization. This review focuses on the contribution of wood waste to both sustainability and the circular economy, considering its use not only as biomass but also as a potential source of bioactive compounds. The main bioactive compounds found in wood are polyphenols, terpenes, polysaccharides, organic compounds, fatty acids, and alkaloids. Polyphenols are the most ubiquitous compounds in wood. Large amounts of hydroxytyrosol (up to 25 g/kg dw), resveratrol (up to 66 g/kg dw), protocatechuic acid (up to 16.4 g/kg), and proanthocyanins (8.5 g/kg dw) have been found in the wood from olive trees, grapevines, almond trees and plum trees, respectively. The bioactivity of these compounds has been demonstrated at lower concentrations, mainly in vitro studies. Bioactive compounds present antioxidant, antimicrobial, antifungal, biostimulant, anti-inflammatory, cardioprotective, and anticarcinogenic properties, among others. Therefore, wood extracts might have several applications in agriculture, medicine, and the food, pharmaceutical, nutraceutical, and cosmetics industries. For example, olive tree wood extract reduced thrombin-induced platelet aggregation in vitro; grapevine tree wood extract acts a preservative in wine, replacing SO2; chestnut tree wood extract has antifungal properties on postharvest pathogens in vitro; and stone tree wood extracts are used for aging both wines and brandies. Moreover, the use of wood waste contributes to the move towards both a more sustainable development and a circular economy.

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Endothelium-Dependent Vasorelaxant Effect of Prunus Persica Branch on Isolated Rat Thoracic Aorta

Cited by 14 publications

References 27 publications

Stone Fruit as Biofactories of Phytochemicals With Potential Roles in Human Nutrition and Health

Stone Fruit as Biofactories of Phytochemicals With Potential Roles in Human Nutrition and Health

Anticancer Activity of Modified Tongyou Decoction on Eca109 Esophageal Cancer Cell Invasion and Metastasis through Regulation of the Epithelial‐Mesenchymal Transition Mediated by the HIF‐1α‐Snail Axis

Wood Waste from Fruit Trees: Biomolecules and Their Applications in Agri-Food Industry

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