Pea pod-mimicking hydroxyapatite nanowhisker-reinforced poly(lactic acid) composites with bone-like strength

Xu, Huan; Ke, Lv; Tang, Mengke; Han, Shang; Zhang, Zi-Lin; Xu, Wenxuan; Fu, Yanan; Wang, Yanqing; Tang, Daoyuan; Huang, Donghui; Zhang, Shenghui; Yang, Haoran; He, Xinjian; Gao, Jiefeng

doi:10.1016/j.ijbiomac.2022.06.211

Cited by 31 publications

(7 citation statements)

References 65 publications

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“…The composite exhibited excellent compressibility as it did not break, allowing the test to be carried out to a strain of more than 90%. The observed improvement in mechanical properties in PLA-SrHAP10 can be attributed to the uniform dispersion of rigid SrHAP particles within the PLA matrix, along with the excellent compatibility between the polymer matrix and reinforcing particles. , This allowed for the efficient transfer of applied forces from the matrix to the fillers and vice versa. , The superior mechanical properties of this composite can also be attributed to its higher crystallinity compared with other samples, as previously observed. Crystalline regions within a polymer matrix typically contribute to enhanced mechanical properties, such as increased stiffness and strength.…”

Section: Resultssupporting

confidence: 62%

Strontium-Substituted Nanohydroxyapatite-Incorporated Poly(lactic acid) Composites for Orthopedic Applications: Bioactive, Machinable, and High-Strength Properties

Shaikh,

Baniasadi,

Mehrotra

et al. 2023

Biomacromolecules

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Traditional metal-alloy bone fixation devices provide structural support for bone repair but have limitations in actively promoting bone healing and often require additional surgeries for implant removal. In this study, we focused on addressing these challenges by fabricating biodegradable composites using poly(lactic acid) (PLA) and strontium-substituted nanohydroxyapatite (SrHAP) via melt compounding and injection molding. Various percentages of SrHAP (5, 10, 20, and 30% w/w) were incorporated into the PLA matrix. We systematically investigated the structural, morphological, thermal, mechanical, rheological, and dynamic mechanical properties of the prepared composites. Notably, the tensile modulus, a critical parameter for orthopedic implants, significantly improved from 2.77 GPa in pristine PLA to 3.73 GPa in the composite containing 10% w/w SrHAP. The incorporation of SrHAP (10% w/w) into the PLA matrix led to an increased storage modulus, indicating a uniform dispersion of SrHAP within the PLA and good compatibility between the polymer and nanoparticles. Moreover, we successfully fabricated screws using PLA composites with 10% (w/w) SrHAP, demonstrating their formability at room temperature and radiopacity when observed under X-ray microtomography (micro-CT). Furthermore, the water contact angle decreased from 93 ± 2° for pristine PLA to 75 ± 3° for the composite containing SrHAP, indicating better surface wettability. To assess the biological behavior of the composites, we conducted in vitro cell-material tests, which confirmed their osteoconductive and osteoinductive properties. These findings highlight the potential of our developed PLA/SrHAP10 (10% w/w) composites as machinable implant materials for orthopedic applications. In conclusion, our study presents the fabrication and comprehensive characterization of biodegradable composites comprising PLA and strontium-substituted nanohydroxyapatite (SrHAP). These composites exhibit improved mechanical properties, formability, and radiopacity while also demonstrating desirable biological behavior. Our results suggest that these PLA/SrHAP10 composites hold promise as machinable implant materials for orthopedic applications.

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Section: Resultssupporting

confidence: 62%

Strontium-Substituted Nanohydroxyapatite-Incorporated Poly(lactic acid) Composites for Orthopedic Applications: Bioactive, Machinable, and High-Strength Properties

Shaikh,

Baniasadi,

Mehrotra

et al. 2023

Biomacromolecules

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“…Second, the roughness of the fracture surfaces was gradually increased while increasing the filler loadings, indicating the dissipation of plentiful energy and even redistribution of the applied stress . Third, ultrafine ligaments bridging the PLA matrix and the rubber domains were normally generated for all the composites, acting as the energy-dispersive units to arrest and localize the penetrating stress that ultimately accommodated remarkable plastic deformation . Overlapping these structural features with the mechanical properties (Figure ), it is therefore hypothesized that the properly devulcanized rubber could benefit the interfacial adhesion and molecular plasticization in a well-balanced manner, holding great potential for toughening PLA composites without sacrificing the strength …”

Section: Resultsmentioning

confidence: 99%

Unexpected Toughening of Poly(lactic acid) by Microwave-Assisted Devulcanization of Waste Latex Rubber

Jiang

et al. 2022

ACS Appl. Polym. Mater.

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Vulcanized, foamed latex rubber features high density of intercommunicated cells and controlled elastomeric properties, rendering wide applications from elastic sponges to rubbery coatings. This provides an emergent incentive for properly recycling, devulcanizing and reusing the waste latex rubber (WLR). Here, a microwave-assisted devulcanization (MAD) approach was disclosed to cleave the cross-links without severe rupture of backbone rubber chains, strategically involving the use of a microwave-assisted hydrothermal reaction at 180 °C for several minutes and incorporation of graphene nanosheets serving as the nanoabsorbers of microwave irradiation. The MAD processing duration was examined to be a vital parameter controlling the macromolecular characteristics: a high devulcanization degree of 83.6% was obtained with 8 min MAD, whereas the soluble content was undesirably increased to 76.2% after 16 min. The devulcanization efficacy was examined by melt compounding with poly(lactic acid) (PLA), displaying extensive interfacial interactions and thereby, creating strong and resilient interfacial adhesion within the PLA composites. With the addition of 10 wt % devulcanized WLR by 8 min MAD, the tensile strength and elongation at break of PLA composites were largely promoted to 58.2 MPa and 16.6%, increasing nearly 62% and 240% compared to those of pure PLA, respectively. The proposed MAD approach may open an environment-respecting and reliable pathway to sustainable recycling of waste rubber, yielding useful components to toughen PLA without sacrificing the strength.

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“…As one of the most representative biodegradable candidates, 15,16 application prospects in the field of air filtration. 17,18 In considering the difficulty of effectively capturing PM 0.3 by the physical interception of fibers solely, the corona charging method is usually utilized to charge the fiber surface of PLA membranes in order to improve the filtration performance.…”

Section: ■ Introductionmentioning

confidence: 99%

“…As one of the most representative biodegradable candidates, , poly(lactic acid) (PLA) has excellent biocompatibility, mechanical properties, and processability, showing broad application prospects in the field of air filtration. , In considering the difficulty of effectively capturing PM 0.3 by the physical interception of fibers solely, the corona charging method is usually utilized to charge the fiber surface of PLA membranes in order to improve the filtration performance. , However, the low dielectric constant of PLA limits its charging capability, resulting in poor long-lasting electrostatic trapping capability. Research shows that the dielectric property of the polymer is a positive factor affecting the charge storage capacity, as well as the particle collection performance .…”

Section: Introductionmentioning

confidence: 99%

Biodegradable MOFilters for Effective Air Filtration and Sterilization by Coupling MOF Functionalization and Mechanical Polarization of Fibrous Poly(lactic acid)

Zhu

Tang

et al. 2023

ACS Appl. Mater. Interfaces

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High-performance air filtration materials are important for addressing the airborne pollutants. Herein, we propose an unprecedented access to biodegradable poly(lactic acid) (PLA)-based MOFilters with excellent filtering performance and antibacterial activity. The fabrication involved a stepwise in situ growth of zeolitic imidazolate framework-8 (ZIF-8) crystals at the surface of microfibrous PLA membranes, followed by mechanical polarization under high pressure and low temperature (5 MPa, 40 °C) to trigger the ordered alignment of dipoles in PLA chains and ZIF-8. The unique structural features allowed these PLA-based MOFilters to achieve an exceptional combination of excellent tensile properties, high dielectric constant (up to 2.4 F/m), and enhanced surface potential as high as 4 kV. Arising from the remarkable surface activity and electrostatic adsorption effect, a significant increase (from over 12% to nearly 20%) in PM0.3 filtration efficiency was observed for the PLA-based MOFilters compared to that of pure PLA counterparts, with weak relation to the airflow velocities (10–85 L/min). Moreover, the air resistance was controlled at a considerably low level for all the MOFilters, that is, below 183 Pa even at 85 L/min. It is worth noting that distinct antibacterial properties were achieved for the MOFilters, as illustrated by the inhibitive rates of 87 and 100% against Escherichia coli and Staphylococcus aureus, respectively. The proposed concept of PLA-based MOFilters offers unprecedented multifunction integration, which may fuel the development of biodegradable versatile filters with high capturing and antibacterial performances yet desirable manufacturing feasibility.

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Pea pod-mimicking hydroxyapatite nanowhisker-reinforced poly(lactic acid) composites with bone-like strength

Cited by 31 publications

References 65 publications

Strontium-Substituted Nanohydroxyapatite-Incorporated Poly(lactic acid) Composites for Orthopedic Applications: Bioactive, Machinable, and High-Strength Properties

Strontium-Substituted Nanohydroxyapatite-Incorporated Poly(lactic acid) Composites for Orthopedic Applications: Bioactive, Machinable, and High-Strength Properties

Unexpected Toughening of Poly(lactic acid) by Microwave-Assisted Devulcanization of Waste Latex Rubber

Biodegradable MOFilters for Effective Air Filtration and Sterilization by Coupling MOF Functionalization and Mechanical Polarization of Fibrous Poly(lactic acid)

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