2018
DOI: 10.1093/jn/nxy096
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Pea Ferritin Stability under Gastric pH Conditions Determines the Mechanism of Iron Uptake in Caco-2 Cells

Abstract: BackgroundIron deficiency is an enduring global health problem that requires new remedial approaches. Iron absorption from soybean-derived ferritin, an ∼550-kDa iron storage protein, is comparable to bioavailable ferrous sulfate (FeSO4). However, the absorption of ferritin is reported to involve an endocytic mechanism, independent of divalent metal ion transporter 1 (DMT-1), the transporter for nonheme iron.ObjectiveOur overall aim was to examine the potential of purified ferritin from peas (Pisum sativum) as … Show more

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Cited by 32 publications
(20 citation statements)
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“…Iron is an essential micronutrient for seed embryo development, and a large proportion of the iron in pea seeds is stored as ferritin, which acts as a store for the seedling following germination ( Ravet et al, 2009 ). Plant ferritin is located in plastids, and so ferritin-iron in seeds is surrounded by multiple membranes, which can hinder the release of iron during digestion ( Moore et al, 2018 ); however, ferritin-iron in its purified form has been shown to exhibit good bioavailability in both pea and soybean ( Lönnerdal et al, 2006 ; Perfecto et al, 2018 ).…”
Section: Micronutrientsmentioning
confidence: 99%
“…Iron is an essential micronutrient for seed embryo development, and a large proportion of the iron in pea seeds is stored as ferritin, which acts as a store for the seedling following germination ( Ravet et al, 2009 ). Plant ferritin is located in plastids, and so ferritin-iron in seeds is surrounded by multiple membranes, which can hinder the release of iron during digestion ( Moore et al, 2018 ); however, ferritin-iron in its purified form has been shown to exhibit good bioavailability in both pea and soybean ( Lönnerdal et al, 2006 ; Perfecto et al, 2018 ).…”
Section: Micronutrientsmentioning
confidence: 99%
“…A large proportion of the iron in pea seeds is stored as ferritin, which acts as an iron store for the seedling following germination (Briat et al 2010). Plant ferritin is located in plastids, meaning that ferritin-iron is surrounded by several membranes, which can hinder the release of iron during digestion (Moore et al 2018); however, ferritin-iron in purified form has good bioavailability (L€ onnerdal et al 2006;Perfecto et al 2018).…”
Section: Micronutrientsmentioning
confidence: 99%
“…Peas are a rich source of ferritin; however, the high phytic acid content within peas can lead to a low level of iron bioavailability [ 30 ]. Purified pea-ferritin iron could indeed provide a suitable alternative, and highly bioavailable, iron source [ 30 , 31 ]. The molecular structure of ferritin has provided inspiration for innovative nanoparticulate forms of iron [ 32 , 33 ].…”
Section: Introductionmentioning
confidence: 99%