PDW and RDW are new parameters for bipolar episodes and unipolar depression

Abstract

INTRODUCTION: Bipolar disorder (BD) and unipolar depression (UD) are complex and multifactorial mental disorders characterized by mood swings, disability, and impaired quality of life. In the present study, we researched the roles of inflammatory cells and their value as inflammation markers in BD and UD. OBJECTIVE: Sixty-nine manic, 60 euthymic, and 70 UD patients and 60 sex-matched healthy volunteers (control group) were retrospectively analysed. Platelet (PLT), platelet distribution width (PDW), and red cell distribution width (RDW) levels were measured in four groups. The aim of this study was to evaluate PLT, PDW, and RDW levels patient with UD and two different phases of BD: euthymic and manic. RESULTS: In our study, 199 patients and 60 controls were included. There were no differences between the patients and the healthy control group participants in terms of age and sex. The bipolar episodes and the UD patient group were statistically significantly different from the healthy controls in terms of PLT, PDW, and RDW. CONCLUSION: Our study is the first in the literature to compare blood PLT, PDW, and RDW levels in bipolar episodes, UD patients, and healthy control groups. We believe that the levels of PLT, PDW, and RDW can be used as novel markers of bipolar episodes and UD. More detailed and larger prospective clinical studies are required to confirm these findings.

Depression and Anxiety Symptoms Are Associated with Mean Platelet Volume in Autoimmune Disorders

“…Elevated MPV values have been attributed to emotional stress [ 40 ], increased sympathetic activity in patients with depression [ 17 , 38 , 41 , 42 ], and in patients with generalized anxiety disorder [ 35 ]. More recently, changes in platelet parameters have been linked to inflammatory processes, thus an abnormal MPV might indicate inflammation in psychiatric conditions [ 43 , 44 ]. However, the exact mechanism behind the association of changes in platelet parameters and affective disorders is not yet clearly established, since there have been results showing significantly decreased MPV in major depression [ 45 ].…”

“…In two previous studies [ 20 , 44 ] it has been demonstrated that ROC curve analysis of PDW and RDW measurements is useful in differentiating healthy controls from the major depressive disorder and manic bipolar disorder groups. In a similar study [ 35 ] the suggested cut-off value for MPV was 7.45 fL, while its sensitivity and specificity for diagnosis of generalized anxiety disorder were 65% and 56.7%, respectively.…”

The effect of cardiac rehabilitation on anxiety and depression in percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) patients

“…Socialization with the other patients going through the same process may have also played a role [22]. The studies revealed that sympathetic activity, hypothalamicpituitary axis stimulation, and inflammatory process may be of significance in the effects of depressive symptoms on the cardiovascular system [23][24][25]. More extensive studies are needed to clarify this mechanism.…”