PDMS-CNT composite for soft bioelectronic neuronal implants

Barshutina, M. N.; Kirichenko, Sergey O.; Wodolajsky, V.A.; Лопачев, А. В.; Barshutin, S.N.; Gorsky, Oleg; Deriabin, Konstantin V.; Sufianov, A.A.; Bulgin, Dmitry; Islamova, Regina M.; Ткачев, А. Г.; Musienko, Pavel

doi:10.1016/j.compositesb.2022.110286

Cited by 10 publications

(5 citation statements)

References 42 publications

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“…Thus, the incorporation of only a 25% CB into PDMS, which was the maximum concentration that could be achieved by Shivashankar et al, increased the modulus by 57% compared to the pristine PDMS, but for the same amount of EFG filler, only a 34% modulus increase was observed. The stiffness of the PDMS composite with carbon nanotubes (CNT) is even more dramatically impacted because with the incorporation of 10% of CNT, the modulus increased by 80% …”

Section: Resultsmentioning

confidence: 99%

Edge-Functionalized Graphene/Polydimethylsiloxane Composite Films for Flexible Neural Cuff Electrodes

Montoya

Wagner

Ryder

et al. 2023

ACS Appl. Mater. Interfaces

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The design of neural electrodes has changed in the past decade, driven mainly by the development of new materials that open the possibility of manufacturing electrodes with adaptable mechanical properties and promising electrical properties. In this paper, we report on the mechanical and electrochemical properties of a polydimethylsiloxane (PDMS) composite with edge-functionalized graphene (EFG) and demonstrate its potential for use in neural implants with the fabrication of a novel neural cuff electrode. We have shown that a 200 μm thick 1:1 EFG/PDMS composite film has a stretchability of up to 20%, a Young’s modulus of 2.52 MPa, and a lifetime of more than 10000 mechanical cycles, making it highly suitable for interfacing with soft tissue. Electrochemical characterization of the EFG/PDMS composite film showed that the capacitance of the composite increased up to 35 times after electrochemical reduction, widening the electrochemical water window and remaining stable after soaking for 5 weeks in phosphate buffered saline. The electrochemically activated EFG/PDMS electrode had a 3 times increase in the charge injection capacity, which is more than double that of a commercial platinum-based neural cuff. Electrochemical and spectrochemical investigations supported the conclusion that this effect originated from the stable chemisorption of hydrogen on the graphene surface. The biocompatibility of the composite was confirmed with an in vitro cell culture study using mouse spinal cord cells. Finally, the potential of the EFG/PDMS composite was demonstrated with the fabrication of a novel neural cuff electrode, whose double-layered and open structured design increased the cuff stretchability up to 140%, well beyond that required for an operational neural cuff. In addition, the cuff design offers better integration with neural tissue and simpler nerve fiber installation and locking.

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Section: Resultsmentioning

confidence: 99%

Edge-Functionalized Graphene/Polydimethylsiloxane Composite Films for Flexible Neural Cuff Electrodes

Montoya

Wagner

Ryder

et al. 2023

ACS Appl. Mater. Interfaces

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“…There are several differences and similarities between the tests. No significant decrease in viability [172] Hyaluronan/CNT hydrogel No significant effect [173] The WST-1 assay comprises the reduction of the tetrazolium salt WST-1 to formazan. It is applied for the measurement of cell mitochondria functionality.…”

Section: Anticipated Research Strategy For Nervous Conduit Implantsmentioning

confidence: 99%

Whether Carbon Nanotubes Are Capable, Promising, and Safe for Their Application in Nervous System Regeneration. Some Critical Remarks and Research Strategies

Zieliński

Majkowska-Marzec

2022

Coatings

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Carbon nanotubes are applied in or considered for different fields of medicine. Among them is the regeneration or rebuilding of nervous system components, which still lack substantial progress; this field is supported by carbon nanotubes to a great extent as the principal material. The limited research on this issue has involved PU/silk/MWCNTs, PCL/silk/MWCNTs, PCL/PGS/CNTs, chitin/CNTs, PGF/CNTs, CNTs/PGFs/PLDLA, MWCNTs/chitosan, MWCNTs/PPy, PLA/MWCNTs, PU/PAA/MWCNts, GelMA/SACNTs, and CNTs alone, which have been subjected to different surface modifications and applied in the form of solid materials or scaffolds that are degradable or nondegradable. So far, these attempts have shown that the use of surface-modified MWCNTs is a promising way to improve the functions of nervous systems as a whole, even though some drawbacks, such as the potential cytotoxicity or the weak adhesion of CNTs to other components, may appear and be eliminated by their proper functionalization. The present review presents an idea of a nonbiodegradable scaffold structure composed of a chosen conductive polymer that is able to create a scaffold structure, a selected nanocarbon form (with MWCNTs as the first candidate), and a corrosion-resistant metal as a conductor. Other substances are also considered for their ability to increase the mechanical strength and adhesion of CNTs and their biological and electrical properties. The novelty of this approach is in the simultaneous use of nanocarbon and conductive metallic fibers in a polymer scaffold structure.

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“…Another problem that cannot be ignored is that most hydrogels are inherently nonconductive, so functional fillers with electrical conductivity should be properly and effectively introduced into hydrogels, endowing hydrogels with excellent electrical properties without compromising their mechanical properties and biocompatibility. , Doping conductive nanofillers with good conductivity and matrix compatibility in hydrogels is a common way to prepare hydrogel sensors. Common conductive nanofillers include carbon nanofillers, , metal nanoparticles/wires, transition-metal carbides, , carbonitride nanosheets, etc. Especially, carbon nanotubes (CNTs) have a nanometer diameter and an ultrahigh aspect ratio, endowing the hydrogel good electrical conductivity and mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Flexible Hybrid Wearable Sensors for Pressure and Thermal Sensing Based on a Double-Network Hydrogel

Zhang,

Luo,

et al. 2023

ACS Appl. Bio Mater.

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Flexible sensors have attracted great attention due to their wide applications in various fields such as motion monitoring and medical health. It is reasonable to develop a sensor with good flexibility, sensitivity, and biocompatibility for wearable device applications. In this study, a double-network hydrogel was obtained by blending poly(vinyl alcohol) (PVA) with poly(ethylene glycol) diacrylate (PEGDA), which combines the flexibility of the PVA network and the fast photocuring ability of PEGDA. Subsequently, polydopamine-coated carbon nanotubes were used as conductive fillers of the PVA−PEG hydrogel matrix to prepare a flexible sensor that exhibits an effective mechanical response and significant stability in mechanics and conductivity. More importantly, the resistance of the sensor is very sensitive to pressure and thermal changes due to the optimized conductive network in the hydrogel. A motion monitoring test showed that the flexible sensor not only responds quickly to the motion of different joints but also keeps the output signal stable after many cycles. In addition, the excellent cell affinity of the hybrid hydrogel also encourages its application in health monitoring and motion sensors.

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PDMS-CNT composite for soft bioelectronic neuronal implants

Cited by 10 publications

References 42 publications

Edge-Functionalized Graphene/Polydimethylsiloxane Composite Films for Flexible Neural Cuff Electrodes

Edge-Functionalized Graphene/Polydimethylsiloxane Composite Films for Flexible Neural Cuff Electrodes

Whether Carbon Nanotubes Are Capable, Promising, and Safe for Their Application in Nervous System Regeneration. Some Critical Remarks and Research Strategies

Flexible Hybrid Wearable Sensors for Pressure and Thermal Sensing Based on a Double-Network Hydrogel

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