Pd(II) and Pt(II) (R,S)-3-aminopyrrolidine complexes. Reactions with 9-ethylguanine and study of their antiproliferative activity

Riera, Xavier; Moreno, Virtudes; Freisinger, Eva; Lippert, Bernhard

doi:10.1016/s0020-1693(02)00957-x

Cited by 12 publications

(8 citation statements)

References 28 publications

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“…3-Aminopyrrolidine dihydrochloride (APDC) (see Figure S1 in the Supporting Information (SI)) has widespread applications in the synthesis of pharmaceuticals, metabolomics studies, and organic synthesis. , Moreover, it contains an endocyclic amine group and an exocyclic amine group, which act as ligands to bind the metal precursors . Under the guidance of APDC, rGO supported Pt@Pd core–shell NFs (Pt@Pd NFs/rGO) were fabricated by a simple, seed-less one-pot aqueous method, and their growth mechanism was discussed in some detail.…”

Section: Introductionmentioning

confidence: 99%

“…30,31 Moreover, it contains an endocyclic amine group and an exocyclic amine group, which act as ligands to bind the metal precursors. 32 Under the guidance of APDC, rGO supported Pt@Pd core−shell NFs (Pt@Pd NFs/rGO) were fabricated by a simple, seed-less one-pot aqueous method, and their growth mechanism was discussed in some detail. The electrocatalytic behaviors of Pt@Pd NFs/rGO were examined by the model ORR and HER systems.…”

Section: ■ Introductionmentioning

confidence: 99%

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One-Pot Seedless Aqueous Synthesis of Reduced Graphene Oxide (rGO)-Supported Core–Shell Pt@Pd Nanoflowers as Advanced Catalysts for Oxygen Reduction and Hydrogen Evolution

Lin

Wang

Fang

et al. 2017

ACS Sustainable Chem. Eng.

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Herein, reduced graphene oxide supported core−shell Pt@Pd nanoflowers (Pt@Pd NFs/rGO) were fabricated by a singlestep, seedless wet-chemical approach at room temperature, only using 3-aminopyrrolidine dihydrochloride (APDC) as the weak stabilizer and structure director. The morphology, structure, and composition of the product were characterized by a series of characterization techniques, and the formation mechanism was discussed in detail. The nanocomposite exhibited improved catalytic activity for oxygen reduction reaction (ORR) with the positive onset potential (E onset , 0.91 V vs. RHE) and half-wave potential (E 1/2 , 0.82 V vs. RHE), and hydrogen evolution reaction (HER) with the low E onset (−39 mV vs. RHE), overpotential (56 mV vs. RHE) at the fixed current density of 10 mA cm −2 , and small Tafel slope (39 mV dec −1 ). This is ascribed to the synergistic effects of the bimetals, rGO as the good support, and electronic coupling between the Pd shell and the Pt core.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

One-Pot Seedless Aqueous Synthesis of Reduced Graphene Oxide (rGO)-Supported Core–Shell Pt@Pd Nanoflowers as Advanced Catalysts for Oxygen Reduction and Hydrogen Evolution

Lin

Wang

Fang

et al. 2017

ACS Sustainable Chem. Eng.

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“…Pd(II)-binding to N(7) shows equally large chemical shift changes (Dd ca. 0.65 ppm) on both H-8 and H-1 protons, which are caused by the accentuated deshielding effect of the metal over the purine ring protons [45]. Therefore, the increased acidity of the proton at N(1) is consistent with the electron-withdrawing effect of the Pd electrophile at N(7) [46][47][48].…”

Section: H Nmr Spectroscopymentioning

confidence: 83%

Palladium(II) binding to N(7) of acyclovir: DNA interaction and herpes simplex virus (HSV-1) inhibitory activity

Gómez-Segura

Caballero

Moreno

et al. 2009

Journal of Inorganic Biochemistry

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“…Asmentionedpreviously,Pd(II)complexesinteractionwith DNAbaseshavethesimilarmechanismasplatinum(II)complexes:theN7ofguanineisthemaintarget [36][37][38] .Inmonofunc-tionalreactionschloroaquaanddiaquacomplexesofTH6were consideredasreactantstointeractwithguanine.…”

Section: Resultsanddiscussion 21 Monofunctionalreactionsmentioning

confidence: 99%

Interaction of a <em>trans</em>-Palladium(II) Complex Containing Planar Amine Ligands with DNA Bases

Zhang¹,

Li-Xin²

2009

Acta Physico-Chimica Sinica

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Palladium(II)complexescoordinatedtolargeplanaramineligandsrepresentaleadstructureofconsiderable interestincurrentantitumordrugdesign.However,thequestioniswhetherthesecomplexescanbindtoDNAbases affordingbifunctionaladductsforgreatsterichindranceprovidedbythebulkyligands.Westudiedtheinteractionof thepalladium(II)complex,PdCl 2 L 2 ,whereLwas2鄄hydroxypydridine,withDNAbasesusingdensityfunctionaltheory andcombiningwithisoelectricfocusingpolarizedcontinuum(IEF鄄PCM)solvationmodel.Activationfreeenergiesfor thecomplexmonofunctionalandbifunctionalbindingtoDNAbaseswerelowerthanthoseforplatinum鄄based antitumoragents.Allreactionsunderstudywereexothermicinaqueoussolution.Theresultsindicatethatthelarge planaramineligandsinthepalladiumcomplexesdonothinderformationofbifunctionaladductswithDNAbases,and theratesformonofunctionalandbifunctionalbindingtoDNAbasestobelargerthanthoseofplatinum鄄basedagents.

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Pd(II) and Pt(II) (R,S)-3-aminopyrrolidine complexes. Reactions with 9-ethylguanine and study of their antiproliferative activity

Cited by 12 publications

References 28 publications

One-Pot Seedless Aqueous Synthesis of Reduced Graphene Oxide (rGO)-Supported Core–Shell Pt@Pd Nanoflowers as Advanced Catalysts for Oxygen Reduction and Hydrogen Evolution

One-Pot Seedless Aqueous Synthesis of Reduced Graphene Oxide (rGO)-Supported Core–Shell Pt@Pd Nanoflowers as Advanced Catalysts for Oxygen Reduction and Hydrogen Evolution

Palladium(II) binding to N(7) of acyclovir: DNA interaction and herpes simplex virus (HSV-1) inhibitory activity

Interaction of a <em>trans</em>-Palladium(II) Complex Containing Planar Amine Ligands with DNA Bases

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