Palladium(II) binding to N(7) of acyclovir: DNA interaction and herpes simplex virus (HSV-1) inhibitory activity

Gómez-Segura, Jordi; Caballero, Santiago; Moreno, Virtudes; Prieto, Marı́a José; Bosch, Anna

doi:10.1016/j.jinorgbio.2008.09.018

Cited by 9 publications

(2 citation statements)

References 48 publications

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“…The microcultures were incubated for 3 d at 378C in 5% CO 2 . The microcultures were examined under the microscope, and TCID 50 was calculated by the Spearman-Kä rber formula (14).…”

Section: Titration Of Herpes Simplex Virus Typementioning

confidence: 99%

Herpes Simplex Virus Type 1-induced FasL Expression in Human Monocytic Cells and Its Implications for Cell Death, Viral Replication, and Immune Evasion

et al. 2011

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Herpes simplex virus type 1 (HSV-1) is a ubiquitously occurring pathogen that infects humans early in childhood. The virus persists as a latent infection in dorsal root ganglia, especially of the trigeminal nerve, and frequently becomes reactivated in humans under conditions of stress. Monocytic cells constitute an important component of the innate and adaptive immune responses. We show here for the first time that HSV-1 stimulates human FasL promoter and induces de novo expression of FasL on the surface of human monocytic cells, including monocytes and macrophages. This virus-induced FasL expression causes death of monocytic cells growing in suspension, but not in monolayers (e.g., macrophages). The addition of a broad-spectrum caspase inhibitor, as well as anti-FasL antibodies, reduced cell death but increased viral replication in the virus-infected cell cultures. We also show here for the first time that the virus-induced de novo expression of FasL on the cell surface acts as an immune evasion mechanism by causing the death of interacting human CD4+ T cells, CD8+ T cells, and natural killer (NK) cells. Our study provides novel insights on FasL expression and cell death in HSV-infected human monocytic cells and their impact on interacting immune cells.

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“…The microcultures were incubated for 3 d at 378C in 5% CO 2 . The microcultures were examined under the microscope, and TCID 50 was calculated by the Spearman-Kä rber formula (14).…”

Section: Titration Of Herpes Simplex Virus Typementioning

confidence: 99%

Herpes Simplex Virus Type 1-induced FasL Expression in Human Monocytic Cells and Its Implications for Cell Death, Viral Replication, and Immune Evasion

et al. 2011

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“…ACV revealed preferential binding to Pd (II) through the N(7) position of the guanine nucleobase. The antiviral efficacy of the derived Pd (II) complex was assayed against HSV-1 strains and outperformed the antiviral activity against HSV-1 of ACV [28]. These modifications greatly improve the production of various dosage forms of ACV, providing more possibilities in treatments for human health.…”

Section: Structures Modification For Improving Acv Performancesmentioning

confidence: 99%

Critical Review of Synthesis, Toxicology and Detection of Acyclovir

Wei

Yao

et al. 2021

Molecules

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Acyclovir (ACV) is an effective and selective antiviral drug, and the study of its toxicology and the use of appropriate detection techniques to control its toxicity at safe levels are extremely important for medicine efforts and human health. This review discusses the mechanism driving ACV’s ability to inhibit viral coding, starting from its development and pharmacology. A comprehensive summary of the existing preparation methods and synthetic materials, such as 5-aminoimidazole-4-carboxamide, guanine and its derivatives, and other purine derivatives, is presented to elucidate the preparation of ACV in detail. In addition, it presents valuable analytical procedures for the toxicological studies of ACV, which are essential for human use and dosing. Analytical methods, including spectrophotometry, high performance liquid chromatography (HPLC), liquid chromatography/tandem mass spectrometry (LC-MS/MS), electrochemical sensors, molecularly imprinted polymers (MIPs), and flow injection–chemiluminescence (FI-CL) are also highlighted. A brief description of the characteristics of each of these methods is also presented. Finally, insight is provided for the development of ACV to drive further innovation of ACV in pharmaceutical applications. This review provides a comprehensive summary of the past life and future challenges of ACV.

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Thermal, spectral, electrochemical and biologic characterization of new Pd(II) complexes with ligands bearing biguanide moieties

Badea

Iosub

Chifiriuc

et al. 2012

J Therm Anal Calorim

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Palladium(II) binding to N(7) of acyclovir: DNA interaction and herpes simplex virus (HSV-1) inhibitory activity

Cited by 9 publications

References 48 publications

Herpes Simplex Virus Type 1-induced FasL Expression in Human Monocytic Cells and Its Implications for Cell Death, Viral Replication, and Immune Evasion

Herpes Simplex Virus Type 1-induced FasL Expression in Human Monocytic Cells and Its Implications for Cell Death, Viral Replication, and Immune Evasion

Critical Review of Synthesis, Toxicology and Detection of Acyclovir

Thermal, spectral, electrochemical and biologic characterization of new Pd(II) complexes with ligands bearing biguanide moieties

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