Pd-catalyzed site selective C–H acetoxylation of aryl/heteroaryl/thiophenyl tethered dihydroquinolinones

Transition‐Metal‐Catalyzed Acyloxylation: Activation of C(sp2)–H and C(sp3)–H Bonds

“…A wide array of aryl/heteroaryl‐substituted dihydroquinolinones 17 showed a tendency towards site‐selective attachment of an acetoxy group at the less sterically hindered position. X‐ray characterization completely confirmed the regioselectivities . The existence of other weakly or strongly chelating ligands, as in ketone 17a or oxime 17b , on this framework did not alter the outcome of the reaction (Scheme ).…”

Palladium‐Catalyzed Regioselective C‐H Bond ortho‐Acetylation and Oxidative Homocoupling of N‐Arylcarbamates

“…This is probably relevant to high electronegativity of the oxygen atom and the sturdy metal–oxygen bond . Hence, several chemists have been interested in constructing carbon−oxygen bonds and different directing groups such as triazole, oxime, purine, dihydroquinolinones, N ‐nitroso, pyrimidines, phosphonic and phosphoric, benzothiazole, amide, and N ‐methoxyamide groups have been employed. Regardless of these progressions, the formation of carbon–oxygen bond still abstains of the notably high standards for efficiency and practicality of the carbon‐hydrogen functionalization catalyzed by Pd.…”

o-Acetoxylation of oxo-benzoxazines via C–H activation by palladium(ii)/aluminium oxide

“…27–31 The majority of direct C–H bond (sp 2 and sp 3 ) acetoxylations for various organic scaffolds have been performed using palladium catalysis. 32–41…”

“…[27][28][29][30][31] The majority of direct C-H bond (sp 2 and sp 3 ) acetoxylations for various organic scaffolds have been performed using palladium catalysis. [32][33][34][35][36][37][38][39][40][41] Benzoxazinones are heterocyclic compounds that contain one nitrogen, one oxygen atom and at least one carbonyl group in a sixmembered ring. Benzoxazinone scaffolds have become one of the most significant medicinal motifs in drug discovery, as illustrated by FDA-approved drugs and drug-like molecules.…”