2017
DOI: 10.1016/j.vaccine.2017.01.064
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PCV13 serotype decrease in Italian adolescents and adults in the post-PCV13 era: Herd protection from children or secular trend?

Abstract: Our study demonstrated a difference in percentage in serotype distribution in adolescents and adults laboratory-confirmed pneumococcal infection between the pre and post-PCV13 eras. This difference is mainly due to the decrease of serotype 7F. Thus, in order to decrease disease burden, adults and in particular the elderly should be offered a specific vaccination program.

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Cited by 11 publications
(5 citation statements)
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“…Laboratory confirmation was obtained by RT-PCR and/or culture methods, as previously described [7,19,26]. Whole blood and/or other biological fluids were collected from all patients as soon as possible after hospital admission for culture and/or molecular tests.…”
Section: Laboratory Methodsmentioning
confidence: 99%
“…Laboratory confirmation was obtained by RT-PCR and/or culture methods, as previously described [7,19,26]. Whole blood and/or other biological fluids were collected from all patients as soon as possible after hospital admission for culture and/or molecular tests.…”
Section: Laboratory Methodsmentioning
confidence: 99%
“…Yet the proportion of cases due to non-PCV serotypes potentially preventable by PPSV23, namely 8, 12FF and 22F, have increased over time, alongside that of those not included in any available vaccine. This replacement phenomenon is well described in other European countries, such as UK, Denmark and France [39,[41][42][43][44][45] and deserves careful monitoring, even more so in the scenario of a progressive coverage of PPSV23 vaccination foreseen by the current NPVP.…”
Section: Epidemiology and Infectionmentioning
confidence: 75%
“…From July 2010, PCV7 was replaced by PCV10 and PCV13 in some regions and later that year PCV13 was introduced into national pneumococcal vaccination programme [38]. Both vaccines have been shown to induce a herd protection effect [12,39,40] and to impact on serotypes circulation dynamics [39,[41][42][43]. Despite its relevance, microbiological surveillance of pneumococcal serotypes in Italy is limited to a fraction, albeit increasing over time, of the reported cases.…”
Section: Epidemiology and Infectionmentioning
confidence: 99%
“…In the United States, the frequency of pneumococcal disease associated with serotype 3 before the introduction of PCV13 was 4% in children and 9% in adults 23 . In European countries such as Italy, serotype 3 was the most frequent in patients above the age of 45 years accounting for 17.3% of the isolates 24 . In Spain, from 2010 to 2013, serotype 3 was one of the most frequent invasive disease serotypes with 12% of isolates recovered from children under five years old and 18% from children over five years old 25 while in Japan, it was the main serotype with a frequency of 14.7% in isolates recovered from adults between 2006 and 2014 26 .…”
Section: Discussionmentioning
confidence: 99%