PCR for HVC, HCV and HIV-1 Experiences and First Results from a Rountine Screening Programme in a Large Blood Transfusion Service

Schottstedt, Volkmar; Tuma, W.; Bünger, G; Lefèvre, Hans

doi:10.1006/biol.1998.0144

Cited by 25 publications

(23 citation statements)

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“…Finally, the distribution of N * can be approximately determined from (25). In view of the fact that γ ≈ 4 × 10 −5 , we can very accurately approximate…”

Section: Approximation Assumptionmentioning

confidence: 92%

Recycled incomplete identification procedures for blood screening

Bar‐Lev

Boxma

Kleiner

et al. 2017

European Journal of Operational Research

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The operation of blood bank systems is characterized by two crucial factors: testing procedures and perishability. We propose a new testing procedure that we term Recycled Incomplete Identification Procedure (RIIP). In RIIP, groups of pooled blood units which are found contaminated in a so-called ELISA test are divided into smaller subgroups and again group-tested by ELISA, and so forth, until finally a so-called PCR test is conducted for those subgroups which are found clean. We analyze and optimize the performance of RIIP, maximizing the profit associated with the procedure. Our numerical results suggest that it may indeed be profitable to do several cycles at ELISA.

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“…Finally, the distribution of N * can be approximately determined from (25). In view of the fact that γ ≈ 4 × 10 −5 , we can very accurately approximate…”

Section: Approximation Assumptionmentioning

confidence: 92%

Recycled incomplete identification procedures for blood screening

Bar‐Lev

Boxma

Kleiner

et al. 2017

European Journal of Operational Research

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“…The exact figures of costs to hospitals of acquiring and processing blood in the US and a survey of hospital-based blood banks and transfusion services are well detailed in (Toner et al, 2011); the annual costs of blood transfusion in the UK are presented in (Varney and Guest, 2003); the cost of blood transfusion in Western Europe from five countries (UK, Sweden, Switzerland, Austria and France) is detailed in (Abraham and Sun, 2012;Schottstedt et al, 1998;Chiavetta et al, 2003;Jackson et al, 2003;AuBuchon, 2003;Stramer et al, 2004;Marshall et al, 2004;Hourfar et al, 2008;Ghandforoush and Sen, 2010;Stramer et al, 2011). Details are omitted for brevity.…”

Section: Blood Screening Proceduresmentioning

confidence: 99%

“…If a blood sample is found clean from both of the stations, then it is stored and ready to be used. Batches found contaminated at ELISA and items found contaminated at PCR, are discarded and not used for blood transfusions (c.f., (Bish et al, 2011;Chick, 1996;Chiavetta et al, 2003;Gastwirth and Johnson, 1994;Hammick and Gastwirth, 1994;Hanson et al, 2006;Hourfar et al, 2008;Jackson et al, 2003;Kantanen et al, 1996;Litvak et al, 1994;Monzon et al, 1991;Schottstedt et al, 1998;Steiner et al, 2010;Stramer et al, 2004;2011;Wein and Zenios, 1996;Zhu et al, 2001).…”

Section: Blood Screening Proceduresmentioning

confidence: 99%

A Stochastic Approach to Blood Supply, Demand and Screening in Central Blood Banks - A Review

Bar‐Lev¹

2017

Current Research in Biostatistics

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Abstract:One of the major issues in securing blood supply to patients worldwide is to provide blood of the best achievable quality, in the needed quantities. Central Blood Services (CBS's) worldwide are daily faced with the problem how to satisfy demands for blood from various hospitals. These hospitals, in their turn, are faced with the problem how to satisfy demands for blood from their patients. To solve these problems in a costeffective way is notoriously difficult, because (i) the amounts of available blood and of blood demand are random, (ii) blood can only be used during a limited amount of time, (iii) one must distinguish various blood components (red blood cells, plasma and platelets) with different associated costs and perishability and (iv) one must distinguish persons with different blood types (like AB + and O − ) with different capabilities to act as donor or as recipient. In this review paper we provide the subject background, describing the blood characteristics and the operation of CBS and hospital blood banks. In particular we describe blood demand, blood components and blood types. We depict blood screening procedures and their processing times and provide with some real data. Particularly we describe a stochastic approach to blood screening and inventory. An emphasis will be given to inventory management and blood allocation, stochastic imput-output of the inventory system and some cost functions involved.

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“…Some manufacturers are PCR-testing smaller plasma pools (to prevent loss of plasma if contamination is demonstrated) but HCV-PCR testing of the individual donor units might be needed. 29 Evidence is lacking at present and serial testing of donors and quarantining of donations may prove to be satisfactory.…”

Section: Individual Screening Of Donors and The Donated Units Of Plasmamentioning

confidence: 99%

Safety and availability of immunoglobulin replacement therapy in relation to potentially transmissable agents

Chapel¹

1999

Clinical and Experimental Immunology

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PCR for HVC, HCV and HIV-1 Experiences and First Results from a Rountine Screening Programme in a Large Blood Transfusion Service

Cited by 25 publications

References 0 publications

Recycled incomplete identification procedures for blood screening

Recycled incomplete identification procedures for blood screening

A Stochastic Approach to Blood Supply, Demand and Screening in Central Blood Banks - A Review

Safety and availability of immunoglobulin replacement therapy in relation to potentially transmissable agents

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