PCL nanofibers loaded with beta-carotene: a novel treatment for eczema

Semnani, Dariush; Nasari, Mina; Fakhrali, Aref

doi:10.1007/s00289-017-2141-9

Cited by 21 publications

(15 citation statements)

References 21 publications

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“…26,27 The ability of b-carotene to induce osteogenic differentiation of stem cells has been reported. [28][29][30] Although there are some recent articles about encapsulation of b-carotene within electrospun bers, [31][32][33] based on our literature survey, no research has been reported on the incorporation of b-carotene within electrospun scaffolds for tissue engineering applications.…”

Section: Introductionmentioning

confidence: 94%

β-Carotene: a natural osteogen to fabricate osteoinductive electrospun scaffolds

et al. 2018

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Section: Introductionmentioning

confidence: 94%

β-Carotene: a natural osteogen to fabricate osteoinductive electrospun scaffolds

et al. 2018

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“…PCL has a low degradation rate because of its semi crystalline structure which lacks hydrophilic groups in its structure. 18 The mechanism of PCL degradation originates from random hydrolytic chain scission of ester linkages which resulted in decrease in molecular weight. 48 The combination of PCL with hydrophilic polymer such as PGS results in the enhancement of degradation rate.…”

Section: Biodegradability Of Nanofibers Matmentioning

confidence: 99%

“…By adding polymers that have some functional groups to this polymer, the final surface of the scaffold provides some sites that lead to cell adhesion. 17,18 One of the essential features of cardiac tissue is the transmission of electrical signals for the simultaneous contractions of cardiomyocytes and the proper function of the heart. In the normal heart, electrical signals are generated by sino-atrial node and released through the atrium into the atrio-ventricular node.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible graphene‐embedded PCL/PGS‐based nanofibrous scaffolds: A potential application for cardiac tissue regeneration

Fakhrali

Nasari

Poursharifi

et al. 2021

J of Applied Polymer Sci

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Research in the field of tissue engineering, especially heart tissue engineering, is growing rapidly. Herein, the morphological, chemical, mechanical and biological properties of poly (caprolactone) (PCL)/poly (glycerol sebacate) (PGS) and PCL/PGS/graphene nanofibrous scaffolds are investigated. Initially, PGS pre-polymer is synthesized and characterized by nuclear magnetic resonance and Fourier transform infrared spectroscopies. Then, in order to use the benefits of PGS, this polymer is mixed with PCL. Blending PGS with PCL resulted in the enhancement of ultimate elongation and reduction in the elastic modulus due to the intrinsic properties of PGS. The hydrophobicity of PCL nanofibers is reduced by adding PGS as hydrophilic polymer (105 ± 3 vs. 44 ± 2 ). Also, the addition of graphene to the blend nanofibers is balanced the hydrophilicity. Degradation rate of pure PCL nanofibers is very slow but it is increased in the presence of PGS. All nanofibrous scaffolds are biocompatible and non-toxic. The highest cell adhesion (covered area = 0.916 ± 0.032) and biocompatibility (98.79 ± 1%) are related to PCL/PGS loaded with 1% wt of graphene (PCL/PGS/graphene 1 ). Thus, this sample can be a good candidate for further examinations of cardiac tissue engineering.

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“…Today, bio‐based polymers and their combining with other nanomaterials or grafting with various monomers finds many application in various areas 30,31 . For example, PCL loaded with beta‐carotene was addressed to treating eczema 32 . Alemi et al 33 were blended PCL with chitosan and carboxy methyl chitosan (CMC) to mesenchymal stem cell differentiation.…”

Section: Introductionmentioning

confidence: 99%

“…30,31 For example, PCL loaded with beta-carotene was addressed to treating eczema. 32 Alemi et al 33 were blended PCL with chitosan and carboxy methyl chitosan (CMC) to mesenchymal stem cell differentiation. The results demonstrated that PCL/CMC nanofibers were good candidate for differentiation of mesenchymal stem cell for cartilage tissue engineering.…”

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confidence: 99%

Electrospun PGS/PCL nanofibers: From straight to sponge and spring‐like morphology

Fakhrali

Semnani

Salehi

et al. 2020

Polymers for Advanced Techs

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Poly(glycerol sebacate) (PGS) is an attractive polymer that has many applications in medical fields, especially in tissue engineering. In this study, the influence of solvent system on electrospinnability, forming of bead-free nanofibers and the morphology of PGS nanofibers was investigated and discussed. Among different solvents, the acidic solvent as a benign solvent was used for electrospinning. The steps were as follows: (a) Synthesis the PGS pre-polymer and analysis its chemical structure by Fourier-transform infrared spectroscopy (FTIR); (b) Electrospinning of the PGS by mixing PCL in eight different solvent systems; (c) evaluation the morphology of produced nanofibers using the scanning electron microscope (SEM); (d) the study of biocompatibility of produced nanofibers by MTT assay. The average diameter of nanofibers in different solvent systems turned out to vary from 260 ± 63 to 4588 ± 970 nm and nanofibers with different morphologies were produced by changing the solvent system. Among the produced straight nanofibers, the best samples were FA 30,15 (formic acid), FA/AC 30,15 (formic acid/Acetone), FA/AA 30,15 (formic acid/acetic acid), CF/DMF 20,15 (chloroform/N,N-dimethylformamide), FA/AA 35,15 , and CF/DMF 23,15 , respectively (based on size and morphology). Also, the produced nanofibers in CF/ET (chloroform/ethanol) had a rough surface. When AA was used as solvent and polymer concentration was kept 35% w/v, sponge-like scaffold was produced. Moreover, spring-like nanofibers were fabricated by using DMF, (at 30% w/v) and AC (in all polymer concentrations). MTT results also demonstrated that CF/DMF 20,15 as produced sample via hazardous solvents (class 3) is biocompatible. These scaffolds can be used in different tissue engineering applications according to their morphology.

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PCL nanofibers loaded with beta-carotene: a novel treatment for eczema

Cited by 21 publications

References 21 publications

β-Carotene: a natural osteogen to fabricate osteoinductive electrospun scaffolds

β-Carotene: a natural osteogen to fabricate osteoinductive electrospun scaffolds

Biocompatible graphene‐embedded PCL/PGS‐based nanofibrous scaffolds: A potential application for cardiac tissue regeneration

Electrospun PGS/PCL nanofibers: From straight to sponge and spring‐like morphology

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